Adipokine-myokine-hepatokine compartment-system in mothers and children: An explorative study

Deibert, Clara; Ferrari, Nina; Flöck, A; Merz, Waltraut M.; Gembruch, Ulrich; Lehmacher, Walter; Ehrhardt, Christina; Gräf, Christine

doi:10.1016/j.conctc.2016.02.002

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…The following participant information was retrieved from either medical files or health insurance cards: age, height, weight (before pregnancy and at admission for labor), parity, ethnicity, level of education, smoking behavior, mode of delivery, presence of gestational diabetes, presence of pre-eclampsia, and other complications during pregnancy (for details see [ 15 , 24 , 25 ]).…”

Section: Methodsmentioning

confidence: 99%

Impact of Diet Quality during Pregnancy on Gestational Weight Gain and Selected Adipokines—Results of a German Cross-Sectional Study

Ehrhardt

Deibert²,

Flöck

et al. 2022

Nutrients

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While nutrition during pregnancy is critical for the health of both mother and child, little is known about the diet quality of women during pregnancy, its correlation with gestational weight gain (GWG)/body composition, and chosen maternal adipokines. Therefore, we evaluated the Healthy Eating Index (HEI) of 110 pregnant women and analyzed its correlation with GWG/body composition, physical activity, leptin, resistin, adiponectin, and interleukin 6 (IL-6), respectively. Diet quality was medium in 63% of women, characterized by a high intake of animal-based products. HEI was negatively influenced by pre-pregnancy obesity (β = −0.335, p = 0.004), and positively influenced by higher age (>35 yrs., β = 0.365, p ≤ 0.001), upper arm circumference (β = 0.222, p = 0.052), and total activity during the third trimester (β = 0.258, p = 0.008). GWG was associated with pre-pregnancy obesity (β = −0.512, p ≤ 0.001), thigh circumference (β = 0.342, p = 0.007), upper arm fat area (β = 0.208, p = 0.092), and maternal age group (>35 yrs. β = −0.166, p = 0.082), but not with HEI. Leptin and IL-6 displayed associations with variables representative of body composition, such as pre-pregnancy BMI, thigh circumference, upper arm fat area, and upper arm circumference, but were not influenced by HEI. Neither were adiponectin and resistin. IL-6 was also associated with total activity. In conclusion, GWG, leptin, and IL-6 were influenced by nutritional status (body composition/pre-pregnancy BMI), not by maternal diet. Physical activity level also had an impact on IL-6. Thus, efforts should be intensified to improve diet quality and participation in sports before and during pregnancy, particularly in overweight or obese women.

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Section: Methodsmentioning

confidence: 99%

Impact of Diet Quality during Pregnancy on Gestational Weight Gain and Selected Adipokines—Results of a German Cross-Sectional Study

Ehrhardt

Deibert²,

Flöck

et al. 2022

Nutrients

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“…This cross-sectional, prospective study was performed between December 2013 and April 2014 in the obstetric unit of a tertiary referral center. The study was part of a larger study, parts of which have been published [28] , [29] , [30] . Study design and consent forms were approved by the institutional ethics committee (number 269/13).…”

Section: Methodsmentioning

confidence: 99%

Resistin in pregnancy: Analysis of determinants in pairs of umbilical cord blood and maternal serum

et al. 2021

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Objective Despite intensive research on the cytokine resistin only few studies investigated mother-newborn-pairs during healthy pregnancy and reported about interactions with clinical obstetric variables or other cytokines. Comparison of existing studies is difficult due to differences between assays, sample collection, gestational age, definition of healthy controls and patient characteristics. Furthermore, differences between rodent models and humans do not allow for a direct comparison. Methods In this cross-sectional, prospective study 109 healthy mother-newborn pairs were analyzed. Maternal venous blood samples were taken on admission to the labor ward; newborn venous blood samples were drawn from the placental part of the umbilical cord (UC), immediately after clamping. Resistin, leptin, adiponectin, TNF-α, IL-6 and brain derived neurotrophic factor (BDNF) serum concentrations were measured with commercially available immunoassays. Determinants of maternal and newborn resistin levels were analyzed using simple and multiple linear regression. Results UC resistin levels were higher than maternal concentrations (median 17.69 ng/mL, IQR 7.36 vs. median 8.04 ng/mL, IQR 4.30). Correlation between UC and maternal resistin levels was moderate (R = 0.503, p < 0.01). In multiple regression analysis levels of maternal resistin and newborn TNF-α remained significant determining factors for UC resistin levels. Gestational age and maternal BDNF-levels remained significant factors for maternal resistin levels. Conclusion In healthy, term newborns and their respective mothers a positive correlation between maternal and newborn levels and an association with gestational age around term can be found and point to a placental source of resistin. Further investigations are needed to clarify the possible contribution of transplacental transport of resistin into the fetal circulation. Except for gestational age most of the clinical obstetric variables tested do not seem to be determining factors for fetal or maternal resistin. Interactions of resistin with other cytokines like TNF-α and BDNF could be the missing link for the conflicting results in literature.

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“…This study was performed as a cross-sectional analysis at the Department of Obstetrics and Prenatal Medicine, University Hospital Bonn (Germany), in cooperation with the German Sport University Cologne (Germany), between December 2013 and April 2014, as previously described [ 29 , 30 ]. A total sample of 91 participants was obtained, with all participants between 36 and 41 weeks of gestation.…”

Section: Methodsmentioning

confidence: 99%

Relationship between Physical Activity and the Metabolic, Inflammatory Axis in Pregnant Participants

Bockler¹,

Ferrari

Deibert³

et al. 2021

IJERPH

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Physical activity (PA) during pregnancy is beneficial for mother and child. Little is known regarding the effects of PA on specific adipokines/myokines and their impact during pregnancy. This study investigates the correlation between PA during late pregnancy, body composition, and maternal levels of leptin, IL-6, and TNF-α at delivery. In a cross-sectional study of 91 pregnant participants (mean age 33.9 ± 4.6 years) without gestational diabetes mellitus or preeclampsia, anthropometric data and blood samples were taken at delivery. PA during the third trimester was measured via the Pregnancy Physical Activity Questionnaire. Activities were ranked by intensity: sedentary (<1.5 metabolic equivalent (METs)), light (1.5–3.0 METs), moderate (3.0–6.0 METs), and vigorous activity (>6.0 METs). Leptin at delivery correlated positively with body composition and negatively with light PA intensity. Sedentary behaviour showed a positive correlation with IL-6 levels at delivery. Moderate activity during the last trimester, sedentary activity levels, and body composition had the greatest influence on maternal IL-6 at delivery. Completed weeks of pregnancy, moderate and light PA, and sedentary activity had the greatest influence on maternal TNF-α at delivery. PA during late pregnancy potentially affects circulating (adipo-)/myokines. Further studies are needed to examine causal relationships and the impact on maternal and new-born health.

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Adipokine-myokine-hepatokine compartment-system in mothers and children: An explorative study

Cited by 7 publications

References 35 publications

Impact of Diet Quality during Pregnancy on Gestational Weight Gain and Selected Adipokines—Results of a German Cross-Sectional Study

Impact of Diet Quality during Pregnancy on Gestational Weight Gain and Selected Adipokines—Results of a German Cross-Sectional Study

Resistin in pregnancy: Analysis of determinants in pairs of umbilical cord blood and maternal serum

Relationship between Physical Activity and the Metabolic, Inflammatory Axis in Pregnant Participants

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