Adipokine signaling in bronchial asthma in combination with overweight

Минеев, В. Н.; Лалаева, Т. М.; Nesterovich, I. I.

doi:10.21638/11701/spbu11.2016.301

Cited by 2 publications

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“…The identified correlations between QI and leptin (positive) and adiponectin (inverse) in Group 1 can be considered taking into account the data on the dependence of adipokin level on body weight [27]. The associations of QI with IL-6, IL-10, IFN-γ in Group 2 and with IL-4 in Group 3 confirm the literature data on the pathogenetic significance of adipose tissue in the development of asthma [10,28].…”

Section: The Interrelations Between Body Mass Index Levels Of Pro-supporting

confidence: 72%

Features of cytokine and adipokine regulation in asthma associated with obesity

Yurenko¹,

Аntonyuk²,

Mineeva³

et al. 2019

Russ Open Med J

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The aim is to establish interrelations between levels of cytokines and adipokines in blood serum of patients with asthma; to reveal the features of cytokine and adipokine regulation in asthma associated with obesity. Material and Methods -We examined 71 patients with partially controlled mild asthma: 24 normal-weight patients (group 1), 24 overweight patients (group 2), 23 patients with grade I and II obesity (group 3). The control group consisted of 25 healthy volunteers. Blood serum levels of Tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and IL-17A were studied by flow cytometry. The concentrations of leptin and adiponectin were measured by an enzyme immunoassay.Results -Increase levels of TNF-α, IL-6, IL-17A and IL-4 have been found in asthma patients regardless of body weight. At the same time, IL-6 level in the groups 2 and 3 was 1.4 times higher than in group 1. IL-17A level in patients with asthma and obesity was 1.2 times higher than in the groups 1 and 2. The elevation of IL-10 level in 1.8 and 2.3 times in patients of groups 2 аnd 3 in comparison with the group 1, respectively, has been determined. Hyperleptinemia was detected in the groups 2 and 3. A positive correlation between the body mass index and the levels of leptin, IL-4, IL-6, IL-10, IFN-γ and an invert correlation between this index and adiponectin concentration has been established. The interrelations between the levels of leptin, pro-and anti-inflammatory cytokines, depending on the body weight, have been revealed. Conclusion -The production of pro-inflammatory cytokines IL-6 and IL-17A, as well as anti-inflammatory cytokine IL-10 enhances in asthma patients as the body weight increases and the obesity develops. The features of cytokine and adipokine imbalance indicate the prevalence of neutrophilic inflammation in asthma with obesity and demonstrates pathogenetic link between obesity and asthma.

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Section: The Interrelations Between Body Mass Index Levels Of Pro-supporting

confidence: 72%

Features of cytokine and adipokine regulation in asthma associated with obesity

Yurenko¹,

Аntonyuk²,

Mineeva³

et al. 2019

Russ Open Med J

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Influence of adipocytokines on the bronchopulmonary system in abdominal obesity

Khudiakova,

Ragino

2023

Pulʹmonologiâ (Mosk.)

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Pathogenesis of chronic lung diseases is assumed to involve systemic inflammation factors, as well as hormone-like substances adipokines produced by adipose tissue, which is an independent endocrine organ. Adipokines cause systemic inflammation under the influence of hypoxemia due to obesity and associated respiratory disorders such as obstructive sleep apnea syndrome, chronic obstructive pulmonary disease, hypoventilation syndrome, etc. However, the influence of specific adipocytes on the development and course of bronchopulmonary diseases remains unclear.Purpose of this review was to evaluate the contribution of some adipocytokines to the development of bronchopulmonary conditions against abdominal obesity. We collected data on adiponectin, adipsin, lipocalin-2, interleukin 6, insulin, glucagon, leptin, monocyte-chemoattractant protein type 1, tumor necrosis factor-α, amylin, glucose-dependent insulinotropic polypeptide, ghrelin, and pancreatic polypeptide in patients with abdominal obesity and bronchopulmonary disorders.Conclusion. The presented data confirm that hormone-like substances produced by adipose tissue make a significant contribution to the severity of respiratory disorders.

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Adipokine signaling in bronchial asthma in combination with overweight

Cited by 2 publications

References 0 publications

Features of cytokine and adipokine regulation in asthma associated with obesity

Features of cytokine and adipokine regulation in asthma associated with obesity

Influence of adipocytokines on the bronchopulmonary system in abdominal obesity

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