2015
DOI: 10.1155/2015/681612
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Adipokines as Drug Targets in Diabetes and Underlying Disturbances

Abstract: Diabetes and obesity are worldwide health problems. White fat dynamically participates in hormonal and inflammatory regulation. White adipose tissue is recognized as a multifactorial organ that secretes several adipose-derived factors that have been collectively termed “adipokines.” Adipokines are pleiotropic molecules that gather factors such as leptin, adiponectin, visfatin, apelin, vaspin, hepcidin, RBP4, and inflammatory cytokines, including TNF and IL-1β, among others. Multiple roles in metabolic and infl… Show more

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Cited by 139 publications
(112 citation statements)
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References 140 publications
(164 reference statements)
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“…Correlations between adipokines or hsCRP and insulin sensitivity in ezetimibe-treated patients were also observed in both younger and older patients, analysed in the present study, but they were weak. This finding as well as only an insignificant decrease in HOMA-IR and in TNF-a, being one of the best markers of insulin sensitivity, causatively linked with its development [3,4], indicate that other mechanisms, not investigated in this study, may contribute to ezetimibeinduced changes in hsCRP, leptin, and adiponectin, and suggest that a favourable effect on adipokines may be observed even in non-insulin-resistant older adults.…”
Section: Discussionmentioning
confidence: 54%
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“…Correlations between adipokines or hsCRP and insulin sensitivity in ezetimibe-treated patients were also observed in both younger and older patients, analysed in the present study, but they were weak. This finding as well as only an insignificant decrease in HOMA-IR and in TNF-a, being one of the best markers of insulin sensitivity, causatively linked with its development [3,4], indicate that other mechanisms, not investigated in this study, may contribute to ezetimibeinduced changes in hsCRP, leptin, and adiponectin, and suggest that a favourable effect on adipokines may be observed even in non-insulin-resistant older adults.…”
Section: Discussionmentioning
confidence: 54%
“…Apart from changes in adipose tissue, the obtained results may be explained by a decrease in sex hormone levels after menopause and in men with late-onset hypogonadism. Considering the role of adiponectin and TNF-a in the regulation of insulin sensitivity [3,4], age-related changes in their plasma levels may either participate in the development of insulin resistance or at least reflect impaired receptor sensitivity.…”
Section: Discussionmentioning
confidence: 99%
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“…This phenomenon of leptin resistance may already be present in obese children. Adiponectin is an adipose-specific hormone that has anti-inflammatory and insulin-sensitizing properties [45]. Observational studies have shown an inverse correlation between plasma adiponectin concentrations and adiposity, insulin resistance and hepatic fat [43][44][45].…”
Section: Nalfd: the Liver At The Centermentioning
confidence: 99%
“…Adiponectin is an adipose-specific hormone that has anti-inflammatory and insulin-sensitizing properties [45]. Observational studies have shown an inverse correlation between plasma adiponectin concentrations and adiposity, insulin resistance and hepatic fat [43][44][45]. Resistin is another adipokine that antagonizes insulin action, causing glucose intolerance, resistin-deficient animals are protected from obesity, whereas an elevated resistin level is associated with insulin resistance [46].…”
Section: Nalfd: the Liver At The Centermentioning
confidence: 99%