Adipokines, diabetes and atherosclerosis: an inflammatory association

Freitas-Lima, Leandro Ceotto; Braga, Valdir de Andrade; Silva, Maria do Socorro de França; Cruz, Josiane de Campos; Santos, Sérgio Henrique Sousa; Monteiro, Matheus Morais de Oliveira; Balarini, Camille de Moura

doi:10.3389/fphys.2015.00304

Cited by 172 publications

(123 citation statements)

References 174 publications

(281 reference statements)

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“…It is a “protective” adipocytokine, involved in the regulation of glucose and lipid metabolism, as well as in inflammation inhibiting NF-κB and TNF-α production in macrophages; consistent with these data, its serum concentrations are inversely related to obesity and diabetes [54]. Adiponectin levels are inversely related to insulin resistance and are lower in obese subjects and patients with established insulin resistance, e.g., in type 2 diabetes, NAFLD/NASH and hypertension.…”

Section: Adipose Tissue Released Compoundsmentioning

confidence: 58%

Pathophysiology of Non Alcoholic Fatty Liver Disease

Petta

Gastaldelli

Rebelos

et al. 2016

IJMS

143

105

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The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

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Section: Adipose Tissue Released Compoundsmentioning

confidence: 58%

Pathophysiology of Non Alcoholic Fatty Liver Disease

Petta

Gastaldelli

Rebelos

et al. 2016

IJMS

143

105

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“…In fact, oxLDL and inflammatory biomarkers are increased in patients with type 2 diabetes (20,21). Therefore, avoiding oxidative and inflammatory processes in diabetic patients may help to the prevention of cardiovascular complications.…”

Section: Discussionmentioning

confidence: 99%

A new fructose-free, resistant-starch type IV-enriched enteral formula improves glycaemic control and cardiovascular risk biomarkers when administered for six weeks to elderly diabetic patients

Mesa

García-Rodríguez²,

Rico³

et al. 2017

Nutr Hosp

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CM, Pérez-Rodríguez M, Pérez-de-laCruz AJ, Gil Á. A new fructose-free, resistant-starch type IV-enriched enteral formula improves glycaemic control and cardiovascular risk biomarkers when administered for 6 weeks to elderly diabetic patients. AbstractBackground: Reducing the dietary glycaemic response has been proposed as a way to reduce the risk of diabetes complications. Objective: The aim of the present study was to evaluate the glycaemic control and cardiovascular risk biomarkers in fragile, elderly type 2 diabetes patients after the intake of a new fructose-free diabetes-specifi c formula enriched with resistant-starch type IV and high in monounsaturated fatty acids. Methods: Forty-one type 2 diabetes patients aged 78.9 ± 2.8 years were fed exclusively with an enteral diabetes-specifi c formula for 6 weeks. Data were collected at baseline and after 6 weeks of feeding. Carbohydrate and lipid metabolism and infl ammatory and cardiovascular risk biomarkers were measured to evaluated the course of diabetes complications. Results: Blood glycated haemoglobin signifi cantly decreased after the intervention (6.1 ± 0.1 vs. 5.8 ± 0.1 %; p < 0,045), as well as monocyte chemotactic protein-1 and soluble E-selectin (p < 0.05), while soluble vascular cell adhesion molecule and plasminogen activator inhibitor-1 tended to decrease from baseline to 6 weeks (p = 0.084 and p = 0.05, respectively). Conclusion:The new product improves glycaemic control and cardiovascular risk without altering lipid metabolism, which is useful for the prevention of diabetic complications. Longer intervention studies are needed in order to validate these results in a larger population.

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“…The reduction of insulin production under the diabetes mellitus affects the absorption of glucose by muscle cells, which leads to muscle dystrophy and muscle mass reduction [164]. Using electron microscopy, the authors of Ref.…”

Section: Different Tissuesmentioning

confidence: 99%

Optical and structural properties of biological tissues under diabetes mellitus

Tuchina

Tuchin

2018

J-BPE

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Abstract. Diabetes mellitus is a serious social and economic problem of modern society because it is widespread and fraught with numerous complications. Therefore, it is necessary to search for new methods of diabetes mellitus diagnostics and treatment and to improve the existing ones, which, in turn, requires thorough investigation of the disease development mechanisms, as well as elaboration of simple and reliable methods and criteria for detecting the complication precursors. In connection with the solution of these problems, in the paper we present an analytical review of recent publications devoted to the study of the changes of structural and optical properties of biological tissues under the conditions of diabetes mellitus development using in vitro models of glycated tissues, in vivo experimental models of diabetes in laboratory animals, and clinical studies.

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Adipokines, diabetes and atherosclerosis: an inflammatory association

Cited by 172 publications

References 174 publications

Pathophysiology of Non Alcoholic Fatty Liver Disease

Pathophysiology of Non Alcoholic Fatty Liver Disease

A new fructose-free, resistant-starch type IV-enriched enteral formula improves glycaemic control and cardiovascular risk biomarkers when administered for six weeks to elderly diabetic patients

Optical and structural properties of biological tissues under diabetes mellitus

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