Adipokines in metabolic and reproductive functions in birds: An overview of current knowns and unknowns

Bernardi, Ophélie; Estienne, Anthony; Reverchon, Maxime; Bigot, Yves; Froment, Pascal; Dupont, Joëlle

doi:10.1016/j.mce.2021.111370

Cited by 19 publications

(21 citation statements)

References 174 publications

(208 reference statements)

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“…In birds, chemerin and its receptors are also expressed within hen ovaries 20 , 21 and a significant positive correlation between chemerin expressional levels in granulosa cells and the weight of the F1 preovulatory follicle exists 22 . In turkeys, the chemerin system is also present in the theca and granulosa cells of ovarian follicles, with higher expression levels in theca cells 20 .…”

Section: Introductionmentioning

confidence: 99%

Chemerin is secreted by the chicken oviduct, accumulates in egg albumen and could promote embryo development

Estienne

Brossaud

Ramé

et al. 2022

Sci Rep

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Understanding of the distribution of chemerin and its receptors, Chemokine-like Receptor 1 (CMKLR1), G Protein-coupled Receptor 1 (GPR1) and Chemokine (C–C motif) receptor-like 2 (CCRL2), in the egg and the embryonic annexes is currently lacking, and their role during embryogenesis remains unknown. By immunoblot using monoclonal anti-chicken antibodies and Enzyme Linked Immunosorbent Assays (ELISA), we found that chemerin is expressed 10 times higher in albumen eggs than in blood plasma, and it is also abundant in the perivitelline membrane but undetectable in yolk. Chicken chemerin can inhibit bacterial growth. By Reverse Transcription—quantitative Polymerisation Chain Reaction (RT-qPCR), western-blot, and immunofluorescence, we show that chemerin is locally produced by the oviduct magnum that participates in albumen formation. Using cultures of magnum explants, we demonstrate that progesterone (P4) and oestradiol (E2) treatment increases chemerin secretion into cultured media and expression in magnum. Chemerin and its three receptors are present in amniotic and Chorio Allantoic Membranes (CAM). Only CMKLR1 expression decreased from embryonic day (ED) 7 to ED11 and remained low until ED18. Chemerin concentrations strongly increased in amniotic fluid at D14 when egg albumen crossed the amniotic membrane. In ovo injections of neutralising chemerin and CMKLR1 antibodies (0.01, 0.1 and 1 µg) increased embryo mortality, which occurred mainly at ED12-13, in a dose-dependent manner. Chemerin treatment increased primary CAM viability. Finally, chemerin and CMKLR1 inhibition within the CAM led to a decrease in blood vessel development and associated angiogenic gene expression. Our results show an important function of the chemerin system during embryo development in chickens, suggesting the potential use of this adipokine as a predictive marker for egg fertility or hatchability.

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Section: Introductionmentioning

confidence: 99%

Chemerin is secreted by the chicken oviduct, accumulates in egg albumen and could promote embryo development

Estienne

Brossaud

Ramé

et al. 2022

Sci Rep

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“…Currently, the studies on avian leptin mainly focus on the reproductive system in growth and development [ 137 , 138 , 139 ]. In poultry, leptin activates the Janus kinase/signal transducer and activator of transcription (JAK–STAT) signaling pathway and regulates energy homeostasis through bending to the leptin receptor [ 140 ].…”

Section: Molecular Mechanism Of Osteocalcin In Flhs Chickensmentioning

confidence: 99%

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Zhang

Jiang

et al. 2023

Animals

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Osteocalcin (OCN) is synthesized and secreted by differentiating osteoblasts. In addition to its role in bone, OCN acts as a hormone in the pancreas, liver, muscle, fat, and other organs to regulate multiple pathophysiological processes including glucose homeostasis and adipic acid metabolism. Fat metabolic disorder, such as excessive fat buildup, is related to non-alcoholic fatty liver disease (NAFLD) in humans. Similarly, fatty liver hemorrhage syndrome (FLHS) is a metabolic disease in laying hens, resulting from lipid accumulation in hepatocytes. FLHS affects hen health with significant impact on poultry egg production. Many studies have proposed that OCN has protective function in mammalian NAFLD, but its function in chicken FLHS and related mechanism have not been completely clarified. Recently, we have revealed that OCN prevents laying hens from FLHS through regulating the JNK pathway, and some pathways related to the disease progression have been identified through both in vivo and vitro investigations. In this view, we discussed the current findings for predicting the strategy for using OCN to prevent or reduce FLHS impact on poultry production.

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“…Данные эффекты наблюдаются у пациенток с ожирением в виде стойких ановуляторных циклов. Исследование на мышах с выключением гена лептина вызвало у испытуемых мышей гипогонадотропный гипогонадизм и привело к бесплодию из-за неспособности гипоталамуса вырабатывать ГнРГ, с последующим восста-новлением фертильности после введения экзогенного лептина [34]. Таким образом, создается парадоксальная ситуация, в которой и при высокой концентрации, и в условиях нехватки лептина развиваются похожие эффекты.…”

Section: адипокины как регуляторы овариальной функции при ожиренииunclassified

Adipokinesand Ghrelin Rolein Regulation of Ovarian Function in Obesity

et al. 2022

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There is a great worldwide trend in the incidence of obesity, which is increasing with each passing year among all populations, including women of reproductive age. Given the impressive list of diseases associated with obesity, as well as the negative inverse correlation of the severity of obesity with fertility, this problem is global not only in the social sphere, but it also becomes demographically significant.Along with other pathogenetic mechanisms leading to persistent anovulation, an imbalance in adipokine production by adipose tissue can also serve as one of the important links in the development of reproductive dysfunction. Despite apparent interest in this topic, a large number of previously discovered adipokines are still not studied. Among adipokines, the effects of adiponectin and leptin on reproductive function are best known. Alterations in adiponectin and leptin levels can affect hypothalamic-pituitary-gonadal signaling, folliculogenesis, oogenesis and steroidogenesis. In addition, leptin is involved in the initiation of puberty, regulation of the menstrual cycle, and changes the balance between proliferation and apoptosis in ovarian cells. The leading causes of reduced fertility, infertility, and IVF failure in obese patients are mechanisms that promote the formation of chronic anovulation, delay the maturation of oocytes, reduce their quality, and/or lead to changes in endometrial susceptibility. These effects can be caused by an imbalance in the concentrations of leptin and adiponectin (leptin excess and adiponectin deficiency), lead to endometrial dysfunction, disruption of implantation and early embryogenesis. These changes, in turn, can affect just as the likelihood of spontaneous conception, so the effectiveness of assisted reproductive technologies and subsequent gestation.Thus, the study of potential pathogenetic pathways of fertility regulation in obesity, one of which is the subject of this review, is an important area for further study.

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Adipokines in metabolic and reproductive functions in birds: An overview of current knowns and unknowns

Cited by 19 publications

References 174 publications

Chemerin is secreted by the chicken oviduct, accumulates in egg albumen and could promote embryo development

Chemerin is secreted by the chicken oviduct, accumulates in egg albumen and could promote embryo development

Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry

Adipokinesand Ghrelin Rolein Regulation of Ovarian Function in Obesity

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