Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Kalafateli, Maria; Triantos, Christos; Tsochatzis, Emmanuel; Michalaki, Marina; Koutroumpakis, Efstratios; Thomopoulos, Konstantinos; Kyriazopoulou, Venetsanea; Jelastopulu, Eleni; Burroughs, Andrew K.; Lambropoulou-Karatza, Chryssoula; Nikolopoulou, V.

doi:10.3748/wjg.v21.i10.3020

Cited by 40 publications

(28 citation statements)

References 55 publications

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“…Increased systemic adiponectin in the cirrhotic patients has been identified in all of the studies ( Table 1 ) [ 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. Importantly, elevated adiponectin is found in the patients independent of disease etiology ( Table 1 ) [ 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. Higher adiponectin was identified in normal-weight and overweight patients independent of the age of the participants in each cohort ( Table 1 ).…”

Section: Adipokines In Liver Cirrhosismentioning

confidence: 99%

“…Higher adiponectin was identified in normal-weight and overweight patients independent of the age of the participants in each cohort ( Table 1 ). Interestingly, there are no associations of serum adiponectin with the homeostasis model assessment (HOMA) index, as a surrogate marker of insulin sensitivity [ 59 , 61 ] or body mass index (BMI) [ 63 , 65 ] in cirrhosis patients. High adiponectin even increases the risk to develop hepatocellular carcinoma in HCV-infected patients [ 66 ] suggesting that the well-characterized hepatoprotective and anti-carcinogenic effects of this adipokine are blocked [ 2 , 67 ].…”

Section: Adipokines In Liver Cirrhosismentioning

confidence: 99%

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Adipokines in Liver Cirrhosis

Buechler

Haberl

Rein-Fischboeck

et al. 2017

IJMS

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Liver fibrosis can progress to cirrhosis, which is considered a serious disease. The Child-Pugh score and the model of end-stage liver disease score have been established to assess residual liver function in patients with liver cirrhosis. The development of portal hypertension contributes to ascites, variceal bleeding and further complications in these patients. A transjugular intrahepatic portosystemic shunt (TIPS) is used to lower portal pressure, which represents a major improvement in the treatment of patients. Adipokines are proteins released from adipose tissue and modulate hepatic fibrogenesis. These proteins affect various biological processes that are involved in liver function, including angiogenesis, vasodilation, inflammation and deposition of extracellular matrix proteins. The best studied adipokines are adiponectin and leptin. Adiponectin protects against hepatic inflammation and fibrogenesis, and leptin functions as a profibrogenic factor. These and other adipokines are supposed to modulate disease severity in patients with liver cirrhosis. Consequently, circulating levels of these proteins have been analyzed to identify associations with parameters of hepatic function, portal hypertension and its associated complications in patients with liver cirrhosis. This review article briefly addresses the role of adipokines in hepatitis and liver fibrosis. Here, studies having analyzed these proteins in systemic blood in cirrhotic patients are listed to identify adipokines that are comparably changed in the different cohorts of patients with liver cirrhosis. Some studies measured these proteins in systemic, hepatic and portal vein blood or after TIPS to specify the tissues contributing to circulating levels of these proteins and the effect of portal hypertension, respectively.

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Section: Adipokines In Liver Cirrhosismentioning

confidence: 99%

Section: Adipokines In Liver Cirrhosismentioning

confidence: 99%

Adipokines in Liver Cirrhosis

Buechler

Haberl

Rein-Fischboeck

et al. 2017

IJMS

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“…Serum apelin levels were decreased in patients with cardiac, renal, and pulmonary fibrosis and PAH . In contrast, serum apelin levels were elevated in patients with liver fibrosis . In this study, we determined that serum apelin levels were negatively correlated with skin sclerosis in SSc patients, which suggests that decreased serum apelin levels might be associated with skin fibrosis in SSc.…”

Section: Discussionmentioning

confidence: 74%

Inhibitory Regulation of Skin Fibrosis in Systemic Sclerosis by Apelin/APJ Signaling

Yokoyama

Sekiguchi

Fujiwara

et al. 2018

Arthritis & Rheumatology

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“…Another recent study [6] reported that in subjects with alcoholic cirrhosis following adjustment for fat mass, visfatin levels were significantly higher from Child-Pugh Class A to Class C.…”

Section: Introductionmentioning

confidence: 99%

Immune-Inflammatory and Metabolic Effects of High Dose Furosemide plus Hypertonic Saline Solution (HSS) Treatment in Cirrhotic Subjects with Refractory Ascites

et al. 2016

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IntroductionPatients with chronic liver diseases are usually thin as a result of hypermetabolism and malnutrition expressed by reduced levels of leptin and impairment of other adyponectins such as visfatin.AimsWe evaluated the metabolic and inflammatory effects of intravenous high-dose furosemide plus hypertonic saline solutions (HSS) compared with repeated paracentesis and a standard oral diuretic schedule, in patients with cirrhosis and refractory ascites.Methods59 consecutive cirrhotic patients with refractory ascites unresponsive to outpatient treatment. Enrolled subjects were randomized to treatment with intravenous infusion of furosemide (125–250mg⁄bid) plus small volumes of HSS from the first day after admission until 3 days before discharge (Group A, n:38), or repeated paracentesis from the first day after admission until 3 days before discharge (Group B, n: 21). Plasma levels of ANP, BNP, Leptin, visfatin, IL-1β, TNF-a, IL-6 were measured before and after the two type of treatment.ResultsSubjects in group A were observed to have a significant reduction of serum levels of TNF-α, IL-1β, IL-6, ANP, BNP, and visfatin, thus regarding primary efficacy endpoints, in Group A vs. Group B we observed higher Δ-TNF-α, Δ-IL-1β, Δ-IL-6, Δ-ANP, Δ-BNP, Δ-visfatin, Δ-Leptin at discharge.DiscussionOur findings underline the possible inflammatory and metabolic effect of saline overload correction in treatment of cirrhosis complications such as refractory ascites, suggesting a possible role of inflammatory and metabolic-nutritional variables as severity markers in these patients.

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Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

Abstract: Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis.

Cited by 40 publications

References 55 publications

Adipokines in Liver Cirrhosis

Adipokines in Liver Cirrhosis

Inhibitory Regulation of Skin Fibrosis in Systemic Sclerosis by Apelin/APJ Signaling

Immune-Inflammatory and Metabolic Effects of High Dose Furosemide plus Hypertonic Saline Solution (HSS) Treatment in Cirrhotic Subjects with Refractory Ascites

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