Adipokines, metabolic dysfunction and illness course in bipolar disorder

Mansur, Rodrigo B.; Rizzo, Lucas B.; Santos, Camila M.; Asevedo, Elson; Cunha, Graccielle R.; Noto, Mariane Nunes; Pedrini, Mariana; Zeni, Maiara; Cordeiro, Quirino; McIntyre, Roger S.; Brietzke, Elisa

doi:10.1016/j.jpsychires.2015.12.003

Cited by 43 publications

(22 citation statements)

References 69 publications

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“…Patients with bipolar disorders exhibit higher rates of obesity and metabolic comorbidities, which are believed to significantly modulate disease outcomes (Crump et al, 2013;McIntyre et al, 2010). Consistent with this, it was recently found that adiponectin levels represent potent moderators of illness course in bipolar depression, suggesting the involvement of metabolic processes in the physiopathology of the illness (Mansur et al, 2016). Interestingly, and supporting further the notion of specific associations with atypical depressive features, obesity in women with established type I bipolar disorder relates to episodes of major depression with atypical characteristics (Pickering et al, 2007).…”

Section: Fat and Depression: A Vicious Circlementioning

confidence: 66%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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Section: Fat and Depression: A Vicious Circlementioning

confidence: 66%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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“…As H 2 O 2 has been shown to be a co‐factor for the activation of the insulin receptor, we hypothesized that the increase of SOD activity was a compensatory response, and that the inverse association in our BD population was possibly evidence of lower resilience in the context of a co‐existing comorbidity. Conversely, metabolic comorbidities are not only highly frequent in BD, but they also have been consistently associated with poor clinical and functional outcomes . Emerging evidence indicates that BDNF has a critical role in cellular and systemic bioenergetics, influencing neuronal glucose regulation and mitochondrial activity, as well as peripheral and central insulin signaling and glucose levels .…”

Section: Discussionmentioning

confidence: 99%

Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder

et al. 2016

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“…First, as an anti-inflammatory cytokine, adiponectin functions as a mediator of inflammatory response and has a protective role against metabolic disturbances (Mazaki-Tovi et al 2009; Lenz and Diamond 2012; Fujita-Shimizu et al 2010). Emerging evidence suggests that adiponectin may be implicated in neurological conditions (Lisik et al 2016; Mansur et al 2016; Hu et al 2015) (Burd et al 2012). To our knowledge, three studies have assessed adiponectin levels in children with ASD (Fujita-Shimizu et al 2010; Blardi et al 2010; Rodrigues et al 2014), of which only one found altered adiponectin levels in subjects with ASD (Fujita-Shimizu et al 2010).…”

mentioning

confidence: 99%

Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

Raghavan

Fallin

Hong

et al. 2018

J Autism Dev Disord

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Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin levels were inversely associated with ASD risk (aOR 0.50; 95% CI 0.33, 0.77), independent of preterm birth, early childhood adiponectin and other known ASD risk factors. Early childhood adiponectin, assessed prior to ASD diagnosis, was associated with lower risk of ASD, which attenuated after adjusting for cord adiponectin, indicating the relative importance of cord adiponectin in ASD risk. Further research is warranted to confirm our findings and elucidate biological mechanisms.

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Adipokines, metabolic dysfunction and illness course in bipolar disorder

Cited by 43 publications

References 69 publications

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder

Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study

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