Adipokines: The missing link between insulin resistance and obesity

Antuna-Puente, Bárbara; Fève, Bruno; Fellahi, Soraya; Bastard, J.-P.

doi:10.1016/j.diabet.2007.09.004

Cited by 634 publications

(503 citation statements)

References 112 publications

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“…The study results are important because obesity is frequently associated with changes in the lipid profile and insulin resistance, together known as the metabolic syndrome [15][16][17] , whose prevalence in adults from the Distrito Federal is 32% 18 . However, risk may exist even when biochemical parameters are within the normal ranges, such as the means observed in the present sample.…”

Section: Discussionmentioning

confidence: 99%

Reducing risk factors in overweight adult users of the family health strategy of the Distrito Federal

et al. 2013

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OBJECTIVE: To evaluate the results of a multidisciplinary program to promote healthy habits on anthropometric and biochemical parameters on participants of the Family Health Strategy of the Distrito Federal. METHODS: The sample consisted of 279 overweight and obese adults of both sexes divided into two groups: intervention (IG, n=198) and control group (CG, n=89). The IG received standard Family Health Strategy care plus a multidisciplinary health promoting program that included dietary interventions and physical activity, called Set Waist Program. The control group received only standard ESF care. Data were collected at baseline and after 4 and 8 months of follow up. Body mass index, waist circumference, fasting blood glucose and lipid profile were assessed. RESULTS: Prevalence of obesity (63.3% to 49.4%, p=0.027) and waist circumference (102.2cm to 94.8cm, p<0.0001) were significantly reduced in IG. Total cholesterol, LDL and HDL-cholesterol were reduced in both groups. CONCLUSION: Reductions in anthropometric measures were maximized through simple interventions that stimulated lifestyle changes. These results suggest that multidisciplinary initiatives such the Set Waist Program can be incorporated into other Family Health Strategy teams to optimize the control of obesity and health promotion. Participant compliance is an issue that deserves further investigation.

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Section: Discussionmentioning

confidence: 99%

Reducing risk factors in overweight adult users of the family health strategy of the Distrito Federal

et al. 2013

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“…In a human study, experimental endotoxemia caused a hyperresistinemic state [42]. In light of this, cytokines have been proposed to increase the levels of resistin, which may contribute to insulin resistance in obesity and several other inflammatory disorders [38,[46][47][48][49][50][51][52][53][54]. Potential roles for resistin in obesity, inflammatory, and other related diseases are shown in Figure 2.…”

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confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

375

297

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“…A high-fat diet increases circulating and adipose MCP1 (7) and promotes monocyte recruitment/retention in adipose (6,8). Paracrine adipose tissue macrophage-adipocyte cross-talk induces adipocyte inflammation, modulates adipocytokines (9), and drives local and systemic insulin resistance and type 2 diabetes (10).…”

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confidence: 99%

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

McGillicuddy

Chiquoine

Hinkle

et al. 2009

Journal of Biological Chemistry

224

189

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Adipokines: The missing link between insulin resistance and obesity

Cited by 634 publications

References 112 publications

Reducing risk factors in overweight adult users of the family health strategy of the Distrito Federal

Reducing risk factors in overweight adult users of the family health strategy of the Distrito Federal

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

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