Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond

Lü, Jinying; Huang, Kuo‐Chin; Chang, Lin-Chau; Huang, Ying-Shing; Chi, Yu-Chiao; Su, T.P.; Chen, Chi‐Ling; Yang, Wei‐Shiung

doi:10.1007/s11373-008-9261-z

Cited by 93 publications

(79 citation statements)

References 165 publications

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“…ADPN may prevent the development of metabolic and atherosclerotic disorders and hypoadiponectinemia is currently considered a predictor of future cardiovascular events [9,10,28]. ADPN also plays an important role in myocardial remodeling [14][15][16]29].…”

Section: Discussionmentioning

confidence: 99%

Hypoadiponectinemia, cardiometabolic comorbidities and left ventricular hypertrophy

et al. 2014

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This study was designed to evaluate the prevalence of cardiometabolic comorbidities and the changes in left ventricular geometry and function in 135 subjects subgrouped according to low or normal total adiponectin plasma (ADPN) levels. Left ventricular (LV) internal diameter/height, total LV mass (LVM) and LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters by pulsed-wave Doppler were calculated. Body mass index (BMI) (p \ 0.0001), waist-to-hip ratio (p \ 0.03), triglycerides (p \ 0,001), prevalence of obesity (p \ 0.005), visceral obesity (p \ 0.003), left ventricular hypertrophy (LVH) (p \ 0.001), metabolic syndrome (p \ 0.0003) and coronary artery disease (CAD) (p \ 0.003) were significantly increased and high-density lipoprotein-cholesterol (p \ 0.001) was significantly reduced in hypo-ADPN than normal-ADPN subjects. LVM, LVMI, interventricular septum thickness and RWT were significantly (p \ 0.0001) higher and left ventricular ejection fraction was significantly (p \ 0.0002) lower in hypo-ADPN than normal-ADPN patients. LVMI correlated directly with BMI (p \ 0.001), mean blood pressure (p \ 0.001), metabolic syndrome (MetS) (p \ 0.001) and inversely with ADPN (p \ 0.0001). The prevalence of LVH (p \ 0.001) and CAD (p \ 0.01) was higher in subjects with normal-ADPN and MetS, while the presence of MetS did not change this finding in hypo ADPN group. Both models of regression analysis indicated that ADPN and BMI resulted independently associated with LVMI. In conclusion, our data seem to indicate that hypoadiponectinemia might be associated with an increased prevalence both of clinical comorbidities and increased LVMI. In this subset of subjects, ADPN and BMI, more than MetS, are able to explain cardiac damage. Accordingly, ADPN might become a new target in the management of cardiometabolic risk.

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Section: Discussionmentioning

confidence: 99%

Hypoadiponectinemia, cardiometabolic comorbidities and left ventricular hypertrophy

et al. 2014

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“…38 Adiponectin is an adipokine that is produced by fat cells, which stimulates insulin sensitivity in muscle and fat cells. 39 On the other hand, alcohol may stimulate insulin sensitivity by increasing the secretion of insulin. In an acute model of alcohol treatment, Huang and Sjöholm 40 showed that alcohol promoted secretion of insulin by the pancreas, and that the increase in insulin secretion was linked to increased insulin sensitivity in alcohol-consuming animals.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption promotes insulin sensitivity without affecting body fat levels

et al. 2009

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Objective: Alcohol consumption promotes insulin sensitivity. In obesity, a decrease in body fat levels decreases the risk of developing insulin resistance; therefore, it is possible that alcohol improves insulin sensitivity by negatively affecting body fat. The aim of this study was to determine whether alcohol consumption promotes insulin sensitivity by reducing body fat levels in C57BL/6 male mice. Methods: We examined the effects of alcohol consumption on insulin sensitivity in male mice with three different body weight (BW) phenotypes. The BWs were induced by feeding the mice a 30% calorie-restricted (CR) regimen, a low-fat (LF) diet and a high-fat (HF) diet. The mice had free access to water or 20% ethanol in the drinking water. To determine the effects of the three different BW phenotypes and of alcohol on glucose regulation and insulin sensitivity, we performed the insulin tolerance test (ITT) and glucose tolerance test (GTT) on the mice. The effects of the diets and alcohol on body composition, percent body fat (% BF), percent lean mass and bone mineral density (BMD) were determined by dual-energy X-ray absorptiometry (DEXA). Results: Data show that mice with the highest body fat levels (HF) were insulin resistant and glucose intolerant. In contrast, mice with the lowest body fat levels (CR) were the most insulin sensitive and cleared the injected endogenous glucose the fastest. Results show that alcohol did not affect GTT in any of the BW phenotypes. However, alcohol consumption promoted insulin sensitivity in mice consuming both the LF and HF diets. Alcohol consumption increased insulin sensitivity without affecting body fat levels, as body fat levels were similar in mice consuming the LF or HF diets and drinking either water or alcohol. Conclusions: Alcohol consumption promotes insulin sensitivity without affecting body fat levels in mice consuming LF and HF diets.

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“…Weight loss through energy restriction has a significant impact on improving cardiovascular disease (CVD) risk profile including favourable changes in adipokines (adiponectin and leptin), hyperlipidaemia, hypertension and insulin sensitivity (1,2). Weight loss also affects the insulin-like growth factor (IGF) system which can modulate carcinogenesis, CVD progression and longevity (3,4).…”

Section: Introductionmentioning

confidence: 99%

Moderate energy restriction-induced weight loss affects circulating IGF levels independent of dietary composition

Belobrajdic

Frystyk

Jeyaratnaganthan

et al. 2010

European Journal of Endocrinology

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Background: Obesity is associated with major changes in the circulating IGF system. However, it is not clear to what extent the IGF system is normalized following diet, and the possible role of different types of diet is also unknown. Objective: To compare changes in the circulating IGF system following 12 weeks of moderate energy restriction (7000 kJ/day) in overweight or obese males on a high protein high red meat diet (HP) or a high carbohydrate diet (HC). Design: Seventy-six men (mean age, 51G1.0 years; body mass index, 32.8G0.5 kg/m

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Adiponectin: a biomarker of obesity-induced insulin resistance in adipose tissue and beyond

Cited by 93 publications

References 165 publications

Hypoadiponectinemia, cardiometabolic comorbidities and left ventricular hypertrophy

Hypoadiponectinemia, cardiometabolic comorbidities and left ventricular hypertrophy

Alcohol consumption promotes insulin sensitivity without affecting body fat levels

Moderate energy restriction-induced weight loss affects circulating IGF levels independent of dietary composition

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