Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation

Abstract

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Bidirectional communication between brain and visceral white adipose tissue: Its potential impact on Alzheimer's disease

“…For example, vWAT contains plenty of adipocytes that are capable to secrete multiple hormones. Many of these hormones have been proved to participate in the pathogenesis of AD ( Table 1 ), including metabolism of Aβ, 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 phosphorylation of tau, 182 , 183 , 189 , 191 , 192 hippocampal neurogenesis, 181 , 193 , 194 neurodegeneration, 181 , 195 synaptic function, 196 , 197 , 198 , 199 , 200 neuroinflammation 186 , 201 , 202 , 203 , 204 , 205 , 206 and oxidative stress. 181 , 182 , 184 , 206 , 207 , 208 All the findings indicate the vWAT-derived hormones could be a mediator between vWAT and AD.…”

Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels

“…Many experimental studies of APN knockout have shown that APN is essential for exercise’s alleviation of brain damage and cognitive dysfunction caused by chronic diseases [ 11 , 12 , 13 , 14 ], and APN plays an important role in alleviating AD. Studies have shown that APN can alleviate AD by reducing the neuronal damage caused by the disease [ 15 , 16 , 17 ]. This neuroprotective effect of APN is achieved, to a certain extent, by the upregulation of the AdipoR1/AMPK signaling pathway, activating autophagy [ 16 , 17 , 18 , 19 ].…”

TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells

“…Therefore, the ferritin protein level is essential for intracellular iron homeostasis. Autophagy performs housekeeping roles through controlling the degradation and recycling of some cytoplasmic proteins [ [60] , [61] , [62] ]. Ferritinophagy is a kind of selective autophagy responsible for the degradation of intracellular ferritin, which is mainly mediated by the cargo receptor, NCOA4 [ 16 , 63 , 64 ].…”