Adiponectin and cancer

Abstract

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Down Syndrome, Obesity, Alzheimer’s Disease, and Cancer: A Brief Review and Hypothesis

“…Possible mechanisms include anti-angiogenesis, induction of apoptosis, activation of tumor-suppressors and activation of cell signaling pathways [ 53 , 54 , 55 ]. Low levels of adiponectin in obese subjects may increase breast cancer risk via hyperinsulinemia and vascular endothelial growth factor (VEGF) upregulation, and high adiponectin levels may reduce risk of breast cancer [ 59 , 60 ]. Growth of leptin-stimulated prostate cancer cells is inhibited by adiponectin [ 58 ].…”

“…In prostate cancer cells, adiponectin reduced cell inhibition induced by p53 and, in breast cancer cells, adiponectin increased p53 and inhibited cell proliferation [ 45 , 90 ]. Adiponectin can also activate other tumor-inhibiting pathways including MAPK, STAT3, AMPK, mTOR, and NF-κB [ 20 , 59 ]. In summary, leptin and adiponectin have opposing effects on cell growth mediated by p53.…”