Adiponectin and Cardiovascular Disease

Jogi, Medhavi; Bajaj, Mandeep S

doi:10.1007/978-1-59745-141-3_10

Cited by 2 publications

(1 citation statement)

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“…Recent studies suggest that it is also synthesized and secreted by human cardiomyocytes (19). The adiponectin gene is located on chromosome 3q27 in humans (20) and expresses a secretory protein that consists of 247 amino acids including a carboxyl-terminal globular domain and an amino-terminal collagen domain (21) and has a structure similar to complement 1q (22) (Fig. 1).…”

Section: Structure Origin and Characteristics Of Adiponectinmentioning

confidence: 99%

Adiponectin and Vulnerable Atherosclerotic Plaques

Barseghian

Gawande²,

Bajaj

2011

Journal of the American College of Cardiology

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High-risk plaques that are vulnerable to rupture demonstrate distinct morphological characteristics. They are differentiated from the lesions responsible for stable coronary artery disease by their large necrotic cores, thin-inflamed fibrous caps, and positive remodeling. Adiponectin is an adipocytokine that is reduced in obesity and type 2 diabetes. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease and acute coronary syndrome in several though not all studies. The involvement of adiponectin provides clues to the inflammatory and atherogenic mechanisms associated with pathological coronary disease progression.

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Section: Structure Origin and Characteristics Of Adiponectinmentioning

confidence: 99%