Adiponectin and other Adipocytokines as Predictors of Markers of Triglyceride-Rich Lipoprotein Metabolism

Chan, Dick C.; Watts, Gerald F.; Ng, Theodore W.K.; Uchida, Yoshiaki; Sakai, Naohiko; Yamashita, Shizuya; Barrett, P. Hugh R.

doi:10.1373/clinchem.2004.045120

Cited by 91 publications

(76 citation statements)

References 44 publications

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“…This hypothesis is consistent with our finding that adiponectin correlated with the FCR of VLDL 1 TG and ApoB and the FTR of VLDL 1 TG, and is consistent with recent data by Ng et al [52]. Notably, adiponectin stimulates (via its action on PPARα) the expression of Apo-CIII, which regulates the metabolism of TGs [53].…”

Section: Discussionsupporting

confidence: 94%

Overproduction of large VLDL particles is driven by increased liver fat content in man

et al. 2006

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Aims/hypothesis: We determined whether hepatic fat content and plasma adiponectin concentration regulate VLDL 1 production. Methods: A multicompartment model was used to simultaneously determine the kinetic parameters of triglycerides (TGs) and apolipoprotein B (ApoB) in VLDL 1 and VLDL 2 after a bolus of [ 2 H 3 ]leucine and [ 2 H 5 ]glycerol in ten men with type 2 diabetes and in 18 non-diabetic men. Liver fat content was determined by proton spectroscopy and intra-abdominal fat content by MRI. Results: Univariate regression analysis showed that liver fat content, intra-abdominal fat volume, plasma glucose, insulin and HOMA-IR (homeostasis model assessment of insulin resistance) correlated with VLDL 1 TG and ApoB production. However, only liver fat and plasma glucose were significant in multiple regression models, emphasising the critical role of substrate fluxes and lipid availability in the liver as the driving force for overproduction of VLDL 1 in subjects with type 2 diabetes. Despite negative correlations with fasting TG levels, liver fat content, and VLDL 1 TG and ApoB pool sizes, adiponectin was not linked to VLDL 1 TG or ApoB production and thus was not a predictor of VLDL 1 production. However, adiponectin correlated negatively with the removal rates of VLDL 1 TG and ApoB. Conclusions/interpretation: We propose that the metabolic effect of insulin resistance, partly mediated by depressed plasma adiponectin levels, increases fatty acid flux from adipose tissue to the liver and induces the accumulation of fat in the liver. Elevated plasma glucose can further increase hepatic fat content through multiple pathways, resulting in overproduction of VLDL 1 particles and leading to the characteristic dyslipidaemia associated with type 2 diabetes.

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Section: Discussionsupporting

confidence: 94%

Overproduction of large VLDL particles is driven by increased liver fat content in man

et al. 2006

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“…A high correlation coefficient between leptin and TG values after exercise (r 5 0.65) was found. Similar results were reported in the study of non-diabetic humans, in which the plasma leptin concentration was directly and highly associated with plasma TG level (Chan et al, 2005).…”

Section: Discussionsupporting

confidence: 89%

Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training

Kędzierski¹,

Kapica²

2008

Animal

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The effect of acute exercise was studied in a group of 42 clinically healthy young Standardbred trotters. These trotters had been divided into four groups according to their age. Their ages were from 1.5 to 3 years. Three jugular venous blood samples were collected via venipuncture from each horse. These samples were collected while (1) at rest, (2) after the end of the exercise and (3) 30 min after the end of the exercise. Exercise showed a significant increase in plasma leptin concentration (3.8 6 0.31 at rest v. 4.3 6 0.37 just after exercise and 4.4 6 0.47 ng/ml after a 30-min rest; ANOVA P , 0.05). The difference between values obtained 30 min after exercise and at rest was significantly greater in 1.5-year-old horses than in those aged 2.5 years (11.3 6 0.43 v. 10.1 6 0.15 ng/ml; ANOVA P , 0.05). The mean plasma leptin concentration was higher in fillies than in colts (4.9 6 0.47 v. 3.5 6 0.36 ng/ml; ANOVA P , 0.05). A positive correlation between the plasma concentrations of leptin and triacylglycerides measured just after exercise was detected (r 5 0.65). The acute exercise significantly increased the plasma concentration of ghrelin that was measured just after exercise (1255 6 55.9 v. 1127 6 54.2 pg/ml; ANOVA P , 0.05). The exercise-induced age-related changes in the plasma ghrelin concentration were significantly lower in 2.5-year-old trotters than in 1.5-year olds. To sum up, the changes in plasma leptin and ghrelin concentrations during bouts of exertion tend to decrease with age and/or training of Standardbred foals.

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“…increased fasting triglycerides and low HDL cholesterol), as it relates to type 2 diabetes and the IRS [47,48]. It has been suggested that adiponectin concentration may play an independent role in regulating TRL metabolism, aside from its link with abdominal fat, insulin resistance and dyslipidaemia [47]. These observations have relevance to a recent finding where a significant correlation was demonstrated between the expression of ADIPOR1 and ADIPOR2 mRNA in human skeletal muscle and in vivo parameters of glucose and lipid metabolism [49].…”

Section: Discussionmentioning

confidence: 90%

“…There has been considerable interest in the role of kinetic defects in triglyceride-rich lipoprotein (TRL) metabolism in the development of atherosclerosis and dyslipidaemia (e.g. increased fasting triglycerides and low HDL cholesterol), as it relates to type 2 diabetes and the IRS [47,48]. It has been suggested that adiponectin concentration may play an independent role in regulating TRL metabolism, aside from its link with abdominal fat, insulin resistance and dyslipidaemia [47].…”

Section: Discussionmentioning

confidence: 99%

Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans

et al. 2006

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Aims/hypothesis The aim of this study was to examine whether genetic variation in ADIPOQ, ADIPOR1 and ADIPOR2 may contribute to increased susceptibility to components of the insulin resistance syndrome (IRS). Materials and methods We genotyped single-nucleotide polymorphisms (SNPs) in ADIPOQ, ADIPOR1 and ADI POR2 in Mexican American subjects (N=439) and performed an association analysis of IRS-related traits. Results Of the eight SNPs examined in the ADIPOQ gene, rs4632532 and rs182052 exhibited significant associations with BMI (p=0.029 and p=0.032), fasting specific insulin (p=0.023 and p=0.026), sum of skin folds (SS) (p=0.0089 and p=0.0084) and homeostasis model assessment of insulin sensitivity (HOMA-%S) (p=0.015 and p=0.016). Two other SNPs, rs266729 and rs2241767, were significantly associated with SS (p=0.036 and p=0.013). SNP rs7539542 of ADIPOR1 was significantly associated with BMI, SS and waist circumference (p=0.025, p=0.047 and p=0.0062). Fourteen of the ADIPOR2 SNPs were found to be significantly (p<0.05) associated with fasting plasma triglyceride concentrations. Four of these SNPs (rs10848569, rs929434, rs3809266 and rs12342) were in high pairwise linkage disequilibrium (r 2 =0.99) and were strongly associated with fasting triglyceride levels (p=0.00029, p=0.00016, p=0.00027 and p=0.00021). Adjusting for the effects of BMI and HOMA-%S on triglyceride concentrations increased significance to p=0.000060 for SNP rs929434. Bayesian quantitative trait nucleotide analysis was used to examine all possible models of gene action. Again, SNP rs929434 provided the strongest statistical evidence of an effect on triglyceride concentrations. Conclusions/interpretation These results provide evidence for association of SNPs in ADIPOQ and its receptors with multiple IRS-related phenotypes. Specifically, several genetic variants in ADIPOR2 were strongly associated with decreased triglyceride levels.

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Adiponectin and other Adipocytokines as Predictors of Markers of Triglyceride-Rich Lipoprotein Metabolism

Cited by 91 publications

References 44 publications

Overproduction of large VLDL particles is driven by increased liver fat content in man

Overproduction of large VLDL particles is driven by increased liver fat content in man

Plasma concentration of leptin and ghrelin in Standardbred foals as related to the age, sex, exercise and training

Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans

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