Adiponectin and the Control of Female Reproductive Functions

Palin, Marie‐France; Bordignon, Vilceu; Murphy, Bruce D.

doi:10.1016/b978-0-12-398313-8.00010-5

Cited by 73 publications

(55 citation statements)

References 252 publications

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“…It can suppress macrophage production of pro‐inflammatory cytokines, inhibit the phagocytic activity of macrophages, inhibit the activation of NF‐κB, and resist TNF‐α‐induced inflammation 32, 33, 34. Adiponectin is thought to function at the intricate interface between metabolism and inflammation in pregnant woman,10 being broadly associated with various obesity‐related diseases including infertility 35, 36…”

Section: Discussionmentioning

confidence: 99%

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

Qin

Tian

Liu

et al. 2016

American J Rep Immunol

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ProblemCpG oligodeoxynucleotides (ODNs) can induce immunological changes in non‐obese diabetic (NOD) mice and increase embryo loss, but little is known about the mechanism. This study aimed to determine the role of adiponectin in CpG ODN‐induced pregnancy failure.Method of studyOligodeoxynucleotide 1826 was intraperitoneally injected to NOD mice, and ODN 2216, ODN 2006, and ODN 2395 were used to stimulate human trophoblast cell lines to investigate adiponectin expression patterns and its possible effects on trophoblast function.ResultsCpG ODNs downregulated adiponectin via the cJun N‐terminal kinase signaling pathway and led to increased embryo loss (from 6.9 to 33.3%). ODN 2006 impaired human trophoblast cell migration, which was successfully rescued by adiponectin treatment.ConclusionCpG ODNs decreased placental adiponectin expression in NOD mice and impaired human trophoblast function and was associated with increased embryo loss. Adiponectin may therefore play an important protective role in the prevention of bacteria‐induced pregnancy failure.

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Section: Discussionmentioning

confidence: 99%

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

Qin

Tian

Liu

et al. 2016

American J Rep Immunol

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“…Some evidence suggests that adiponectin could regulate ovarian function and affect the embryo at very early stages of pregnancy during the pre-implantation period (Palin et al, 2012). In the bovine species, adiponectin and its receptors are present in different follicular cells (oocytes, theca, granulosa and cumulus cells) and luteal cells (Maillard et al, 2010) (Table 1).…”

Section: Metabolic Hormonesmentioning

confidence: 99%

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Dupont

Scaramuzzi

Reverchon

2014

animal

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The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.

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“…Furthermore, recent evidence suggests that adiponectin has a direct peripheral role in regulation of reproductive functions [2]. Two receptors (Adipor1 and Adipor2) have been identified for adiponectin in different species including humans, rodents, pigs, chicken, and cows [5]. Previous studies have clearly shown that adiponectin and its receptors are expressed by follicular cells (granulosa and theca cells), the oocyte and the corpus luteum in several species.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have clearly shown that adiponectin and its receptors are expressed by follicular cells (granulosa and theca cells), the oocyte and the corpus luteum in several species. Moreover, the adiponectin accumulates in the follicular fluid from a local source and/or from circulation [5].…”

Section: Introductionmentioning

confidence: 99%

The In Vitro Effect of Adiponectin on Early Bovine Embryonic Development and Transcriptomic Markers of Oocyte Competence

MR¹,

Kafi²

2016

JFIV Reprod Med Genet

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Objectives: The current study aimed to investigate the in vitro effects of physiologic concentration of adiponectin in follicular fluid of pre-ovulatory bovine ovarian follicles on: 1) the bovine oocyte maturation and the early developmental rates of bovine embryos in vitro; 2) the expression profiles of some developmentally important marker genes in the bovine cumulus cells and oocytes. Materials and Methods:The cumulus-oocyte complexes (COCs) were aspirated from abattoir ovaries and cultured in vitro in the presence/absence of the recombinant human (rh) adiponectin (5 µg/mL) and used for real time RT-QPCR and in vitro embryo production assays.Results: Adiponection had no significant effects on nuclear maturation and cumulus expansion rates (p > 0.05). The expression levels of hyaluronic synthase 2 gene (Has2) was significantly higher in the adiponection group compared to the control group (p = 0.014). However, the early embryonic development was not affected significantly in the presence of adiponectin. Adiponectin did not change the expression rates of adiponectin receptors or other markers of oocyte competence. Also, the expression rates of two important oocyte secreted factors (OSFs), bone morphogenetic protein 15 (Bmp15) and growth/differentiation factor 9 (Gdf9) were not affected (p > 0.05). Conclusions:Adiponection did not affect the bovine oocyte developmental competence and early embryo development in spite of a significant increase in the expression level of Has2 gene, a biomarker of the future oocyte developmental competence.

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Adiponectin and the Control of Female Reproductive Functions

Cited by 73 publications

References 252 publications

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

The In Vitro Effect of Adiponectin on Early Bovine Embryonic Development and Transcriptomic Markers of Oocyte Competence

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