Adiponectin, but Not Leptin or High-Sensitivity C-Reactive Protein, Is Associated with Blood Pressure Independently of General and Abdominal Adiposity

Sung, Shih Hsien; Chuang, Shao Yuan; Sheu, Wayne Huey Herng; Lee, Wen Jane; Chou, Pesus; Chen, Chen Huan

doi:10.1291/hypres.31.633

Cited by 20 publications

(10 citation statements)

References 37 publications

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“…Adiponectin, as a marker of metabolic syndrome, 40 and leptin, as an indicator of the amount of adipose tissue mass, 41 have been associated with insulin resistance and HT. 42 Patel et al 43 found inverse association of adiponectin with insulin resistance, visceral adiposity, and positive family history of coronary heart disease, HT and type 2 diabetes in young adults. However, we did not find any significant differences in adiponectin and leptin levels between the groups nor association of those two markers with elevated blood pressure or insulin resistance.…”

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confidence: 99%

Insulin resistance in young, lean male subjects with essential hypertension

Penesová

Cizmárová²,

Белан

et al. 2010

J Hum Hypertens

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Impaired insulin action, frequently found in essential hypertension (HT), is modified by other factors, such as higher age, accumulation of body fat, dyslipidaemia, impaired glucose metabolism and endothelial dysfunction. In addition, antihypertensive and insulin-sensitizing medication itself may significantly affect cardiovascular and metabolic milieu. The aim of this study was to assess insulin sensitivity, acute insulin response, lipidaemic status and the adipokines' concentrations with regard to abdominal fat distribution in young, lean male subjects with treatment-naïve essential HT and in matched healthy normotensive (NT) subjects. We studied 27 HT patients (age: 19.9 ± 0.6 years; body mass index (BMI): 22.9±0.5 kg m À2) and 15 NT controls (age: 22.3±1.0 years; BMI: 23.7 ± 0.6 kg m À2). The subjects underwent an oral and an intravenous glucose tolerance test (OGTT, IVGTT) on separate days in random order. Higher fasting insulin (Po0.001), non-esterified fatty acids (Po0.05) and plasminogen activator inhibitor factor 1 concentrations (Po0.05) were found in HT patients when compared with NT patients. Despite comparable anthropometric parameters and body fat distribution assessed by magnetic resonance imaging in both groups, newly diagnosed untreated young hypertensive male subjects showed decreased insulin sensitivity, augmented insulin response to both oral and intravenous glucose load (Po0.01; Po0.05 respectively) and 'higher still normal' 2-h plasma glucose levels during OGTT. Untreated, young, lean hypertensive male subjects, with distribution of abdominal adipose tissue and lipid profile comparable with their healthy NT matched counterparts, showed considerable signs of insulin resistance and hyperinsulinaemia. We hypothesize that insulin resistance is the initial feature, which is influenced by several environmental factors, and HT is one of their common consequences.

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confidence: 99%

Insulin resistance in young, lean male subjects with essential hypertension

Penesová

Cizmárová²,

Белан

et al. 2010

J Hum Hypertens

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“…37 Our data suggest that the independent adiponectin-BP association observed in the normotensive population supports a protective role for adiponectin in the development of hypertension. 10 The biological mechanisms by which leptin affects BP remain controversial. Leptin might activate the sympathetic nervous system to affect BP.…”

Section: Association Of Leptin With Adiponectinmentioning

confidence: 99%

“…9 Although it is not clear whether adiponectin independently affects BP regulation, reduced levels of adiponectin have been observed in hypertensive subjects. 10 Limited data on adipokines and blood pressure (BP) exist for adolescents, especially in a relatively lean Chinese population. 11,12 As compared with adulthood, adolescence is a period of rapid physical growth and functional maturation, accompanied by growing gender differences in anthropometric measurements, BP, body composition, hormones and metabolism.…”

Section: Introductionmentioning

confidence: 99%

Association of adipokines with blood pressure in rural Chinese adolescents

et al. 2011

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Previous research has demonstrated that adipokines influence blood pressure (BP). Limited data exist in healthy adolescents, who are in a critical period for preventing the development of high BP. This study investigated the association of leptin, adiponectin and the leptin-to-adiponectin ratio (LAR) with BP in rural Chinese adolescents. This report included 1245 adolescents (average body mass index: 19.3 kg m À2 ) aged 13-21 years from an established twin cohort. We examined gender-specific associations between plasma adipokines and BP, with adjustment for measures of adiposity and insulin resistance (IR). We estimated the genetic contribution to adipokines using the twin design and Cholesky decomposition models. There was no correlation between leptin and adiponectin levels. Leptin was positively associated with systolic blood pressure (SBP) in males and diastolic blood pressure in females, but the association disappeared after adjusting for adiposity and IR. LAR was positively associated with SBP (b(s.e.): 1.94(0.45)), Po0.01), adiponectin was negatively associated with SBP (b(s.e.): À2.18(0.63)), Po0.001) only in males, and such associations were independent of adiposity and IR. A test of gender Â adiponectin interaction was significant (P ¼ 0.01). Heritability estimation showed that both environmental and genetic factors contribute to variance in adipokines. In these relatively lean Chinese adolescents, leptin was positively associated with BP in both genders, but was adiposity/IR dependent. Adiponectin was negatively associated with SBP in males, independent of adiposity/IR.

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“…1 The association between a low plasma adiponectin level and an unfavourable metabolic and cardiovascular profile has been shown in several studies. [2][3][4][5][6][7][8][9][10][11][12] The adiponectin level is reduced in subjects with hypertension 9,11,12 and the reduced adiponectin level has been claimed to be an independent risk factor for hypertension in cross-sectional studies. 13 The biological mechanisms responsible for the association of the reduced adiponectin level with higher blood pressure are not known at present 5 and the specific biological role of adiponectin still awaits clarification.…”

Section: Introductionmentioning

confidence: 99%

“…After adjustment for confounding factors, the association still remained significant between SBP and adiponectin, but not between DBP and adiponectin. 14 Recently, Sung et al 12 in their communitybased survey of 2045 residents aged X40 years found that adiponectin was independently associated with SBP and DBP in a subgroup of their 1512 non-diabetic, non-hypertensive population.…”

Section: Introductionmentioning

confidence: 99%

Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status

2009

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The objective of this study was to analyse the relationship between the ambulatory blood pressure (ABP) measurement and plasma adiponectin levels in a population-based cohort. Non-hypertensive, non-diabetics from the Oulu Project Elucidating Risk of Atherosclerosis cohort aged 40-60 years with ABP measurement available in 226 men and 236 women were analysed. ABP was recorded using the fully automatic SpaceLabs 90207 oscillometric unit. Plasma adiponectin concentrations were assayed using the enzyme-linked immunosorbent assay method. Without adjustment the highest plasma adiponectin tertile was associated with the lowest ABP and office BP measurements (P from 0.025 to Po0.001, respectively). Only the association of plasma adiponectin concentration with systolic ABP was independent of other conventional risk factors (age, body mass index (BMI), waist, gender, insulin sensitivity index, smoking and alcohol consumption) for hypertension (P ¼ 0.017). No association was observed between systolic dipping pattern and adiponectin level. The plasma high adiponectin concentration is independently associated with low daytime systolic ABP value. The mechanisms may include effects on endothelial function and the sympathetic nervous system.

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Adiponectin, but Not Leptin or High-Sensitivity C-Reactive Protein, Is Associated with Blood Pressure Independently of General and Abdominal Adiposity

Cited by 20 publications

References 37 publications

Insulin resistance in young, lean male subjects with essential hypertension

Insulin resistance in young, lean male subjects with essential hypertension

Association of adipokines with blood pressure in rural Chinese adolescents

Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status

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