Adiponectin, cardiovascular disease, and mortality: Parsing the dual prognostic implications of a complex adipokine

Kizer, Jorge R.

doi:10.1016/j.metabol.2014.06.011

Cited by 44 publications

(55 citation statements)

References 40 publications

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“…Despite the general consideration of adiponectin as a protective molecule, increased concentrations of adiponectin in patients with type 1 diabetes were independently associated with all-cause and cardiovascular mortality [31]. The role of adiponectin in determining CVD health, especially in relation to heart failure [32] was recently summarized in the journal [33][34][35].…”

Section: Adipokines As Predictors Of Mortality and Obesity Related DImentioning

confidence: 99%

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

2015

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Section: Adipokines As Predictors Of Mortality and Obesity Related DImentioning

confidence: 99%

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

2015

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“…Indeed, investigations have shown that high levels of adiponectin are associated with increased risk of CVD and mortality in older men 11 . Although, this adiponectin paradox remains poorly understood 12 .…”

Section: Introductionmentioning

confidence: 99%

Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study

Agostinis‐Sobrinho

Santos

Moreira

et al. 2016

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aim: Paradoxically, recent investigations have showed that adiponectin levels are inversely associated with muscle strength. However, to date, there is a lack of knowledge on the relationship between muscular fitness (MF) and adiponectin levels in adolescents. We aimed to examine the independent associations between MF and adiponectin levels in adolescents, controlling for several potential confounders. Methods and results: This is a cross-sectional analysis with 529 Portuguese adolescents aged 12-18 years. A MF score was computed as the mean of the handgrip strength and standing long jump standardized values by age and gender. We measured fasting glucose, insulin, HDL-cholesterol, C-reactive protein and adiponectin. Linear regression analysis showed a significant inverse association between adiponectin (Z-score by age and sex) and MF score, after adjustments for age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, body mass index, HOMA-IR, HDL-cholesterol, C-reactive protein and cardiorespiratory fitness (unstandardized β = -0.176; p < 0.005). Analysis of covariance showed a significant difference between the Low MF/Non-overweight group and the High MF/Non-overweight Group (p < 0.05) and between the Low MF/Non-overweight and High MF/Overweight Group (p < 0.05) (F (5, 523) = 2.262, p = 0.047). Conclusion: Adiponectin circulating levels are inversely and independently associated with MF. In nonoverweight adolescents, those with high levels of MF presented lower levels of adiponectin compared to those with Low MF. Likewise, overweight adolescents with High MF presented lower levels of serum adiponectin than non-overweight adolescents with Low MF.

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“…On the other hand, several GSK3 inhibitors are currently being developed and tested for the treatment of Alzheimer's disease (59,60). In view of the present observations, those substances may share with lithium (50) the negative influence on serum adiponectin levels, potentially leading to a negative cardiovascular safety profile (55,61). Clearly, further research is needed to analyze the impact of GSK3-dependent adiponectin production on the adverse effects of GSK3 inhibitors.…”

Section: Discussionmentioning

confidence: 90%

“…Adiponectin deficiency favors not only metabolic syndrome, but also the development of typical sequelae such as atherosclerosis, coronary heart disease, inflammation, and even some forms of cancer (54)(55)(56)(57). Therefore, efforts are undertaken to elucidate the signaling of adiponectin production and to generate agonists of the adiponectin receptor (58).…”

Section: Discussionmentioning

confidence: 99%

PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome

Chen

Fajol

Hoene³

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Metabolic syndrome is characterized by insulin resistance, obesity, and dyslipidemia. It is the consequence of an imbalance between caloric intake and energy consumption. Adiponectin protects against metabolic syndrome. Insulin-induced signaling includes activation of PI3 kinase and protein kinase B (PKB)/Akt. PKB/Akt in turn inactivates glycogen synthase kinase (GSK) 3, a major regulator of metabolism. Here, we studied the significance of PI3K-dependent GSK3 inactivation for adiponectin formation in diet-induced metabolic syndrome. Mice expressing PI3K-insensitive GSK3 (gsk3 KI ) and wild-type mice (gsk3 WT ) were fed a high-fat diet. Compared with gsk3 WT mice, gsk3 KI mice were protected against the development of metabolic syndrome as evident from a markedly lower weight gain, lower total body and liver fat accumulation, better glucose tolerance, stronger hepatic insulin-dependent PKB/Akt phosphorylation, lower serum insulin, cholesterol, and triglyceride levels, as well as higher energy expenditure. Serum adiponectin concentration and the activity of transcription factor C/EBPα controlling the expression of adiponectin in adipose tissue was significantly higher in gsk3 KI mice than in gsk3 WT mice. Treatment with GSK3 inhibitor lithium significantly decreased the serum adiponectin concentration of gsk3 KI mice and abrogated the difference in C/EBPα activity between the genotypes. Taken together, our data demonstrate that the expression of PI3K-insensitive GSK3 stimulates the production of adiponectin and protects from diet-induced metabolic syndrome.obesity | insulin resistance | triglycerides | leptin

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Adiponectin, cardiovascular disease, and mortality: Parsing the dual prognostic implications of a complex adipokine

Cited by 44 publications

References 40 publications

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

Association between serum adiponectin levels and muscular fitness in Portuguese adolescents: LabMed Physical Activity Study

PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome

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