Adiponectin concentrations as a criterion of metabolic control in persons with type 2 diabetes mellitus?

Abstract

1) Do persons with type 2 diabetes have lower ADP values than individuals without DM but with a high risk of ATS complications? 2) Do ADP values differ between persons with well controlled and persons with uncontrolled type 2 diabetes? We examined 109 patients of the Metabolic Center of Hospital Sternberk. Out of them, 58 had type 2 diabetes, others were individuals with variously expressed risk factors of early atherosclerosis (obesity, hypertension, age, family history, smoking, dyslipidemia, etc.). In all persons under this study the following parameters were determined in peripheral venous blood: adiponectin, resistin, leptin, ObRe, cholesterol, HDL-cholesterol, triacylglycerols, glucose, HbA1c, creatinine, urea, ALT, AST, CRP, homocysteine, thrombocyte aggregation after CPG induction. The whole group was divided according to the presence of type 2DM into two subgroups; persons with diabetes were divided into the well controlled and uncontrolled subgroups. All data obtained were processed statistically using the software SPSS for Windows and Medcalc. The adiponectin/BMI index correlated negatively with HbA1c value (correlation coefficient -0.37, p = 0.00053), triacylglycerols (-0.4, p = 0.000001), P-glucose (-0.3, p = 0.0017), uricemia (-0.35, p = 0.0007) and positively with HDL-cholesterol value (0.6, p=0.00001). Women had higher adiponectin values than men. Persons with hypertension and with diabetes mellitus, individuals with atherogenic lipotype or persons with inflammation signs had lower values than individuals without these diseases and syndromes. Persons with wellcontrolled diabetes mellitus had higher values than persons with uncontrolled diabetes (medians of the adiponectin/BMI index 9.7 vs. 6.7, p < 0.01). Persons with type 2 diabetes mellitus have lower ADP values than persons with a high ATS risk without diabetes mellitus. Persons with wellcontrolled diabetes mellitus (DM) and with satisfactory compensation have significantly higher ADP levels (independently of other metabolic parameters of DM control). ADP may be a new marker of metabolic control in persons with a high risk of atherosclerotic complications.

The relationship between adiponectin and blood pressure in premenopausal and postmenopausal women

“…In the postmenopausal group, MBP was signi cantly, positively and independently correlated with TG, while a correlation was no longer observed between the MBP and adiponectin/BMI Discussion e present study showed a signi cant and independent inverse correlation between adiponectin/BMI and MBP in premenopausal, but not postmenopausal, women. While the present study also showed a signi cant and independent correlation between adiponectin/BMI and TG (inverse) and HDLcholesterol (positive), these results were consistent with a previous study [25]. e nding of a signi cant inverse correlation between adiponectin/BMI and MBP only in premenopausal women suggests that menopause can a ect the adiponectin-BP relationship; namely, premenopause may be a relatively speci c condition during which this relationship exists.…”

“…e objective of the present study was to investigate the relationship between adiponectin and BP in premenopausal and postmenopausal women. Considering that adiponectin is derived speci cally from adipose tissue, the level of BMIadjusted adiponectin (adiponectin/BMI) was used as a measure of adiponectin in this study, as reported previously [25][26][27].…”

Do low levels of circulating adiponectin represent a biomarker or just another risk factor for the metabolic syndrome?

“…Dyslipidaemia is a metabolic syndrome risk factor identified by (a) high circulating TAG or (b) a low level of HDL cholesterol (table 1). Similar to obesity and insulin resistance, numerous studies have shown that dyslipidaemia is associated with low circulating adiponectin even in the absence of other metabolic syndrome risk factors [36,89,[108][109][110][111][112][113][114][115][116][117][118][119][120]. The possibility that low adiponectin levels may trigger dyslipidaemia is corroborated by the link between the G276G polymorphism (intron 2) compared with the G/T and T/T genotypes [121].…”

The Association Between Serum Adiponectin Level and Glycemic Control

“…Resistin, leptin ve ObRe ile adiponektin arasında belirgin ilişki saptanmamıştır. Çalışmayı yürütenler sonuç olarak; tip 2 diyabetik hastaların diğer yük-sek aterosklerotik risk taşıyan popülasyondan daha düşük serum adiponektin seviyelerine sahip olduğu, iyi glisemik kontrol yapılan hastaların daha yüksek serum adiponektin düzeyine sahip olduğu ve adiponektinin metabolik kontrol ve aterosklerotik risk açısından iyi bir belirteç olduğunu değerlendirmişlerdir [15]. Okamoto ve ark.…”

“…Epidemiyolojik çalışmalarda insülin direncinin KVH risk faktörü olduğu ortaya konulmuştur. İnsülin direnci; dislipidemi, obezite, diyabet ve hipertansiyon ile ilişkilidir [15]. Hipertansiyona %30-50 insülin direncinin eşlik ettiği bildirilmiştir ve birçok çalışmada kan basıncı ile açlık plazma insülin arasındaki anlamlı ilişki gösterilmiştir.…”