Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells

Illiano, Michela; Nigro, Ersilia; Sapio, Luigi; Caiafa, Ilaria; Spina, Annamaria; Scudiero, Olga; Bianco, Andrea; Esposito, Sabrina; Mazzeo, Filomena; Pedone, Paolo V.; Daniele, Aurora; Naviglio, Silvio

doi:10.1016/j.pupt.2017.05.009

Cited by 47 publications

(33 citation statements)

References 51 publications

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“…Over the past few years, AdipoR is emerging as a possible candidate for the treatment of different pathological conditions, including metabolic, cardiovascular, and psychiatric disorders, specifically comorbidity between depression and obesity [22][23][24]. According to the antitumor effects observed in response to Acrp30 [25,26] and the opposite relation between its circulating levels and risk of developing cancer [27], initial reports have also investigated the possible anticancer role of AdipoRon in preclinical models, especially in pancreatic and ovarian cancer [28][29][30]. To our knowledge, no evidence has been published yet concerning the possible antiproliferative properties of AdipoR and more in general of Acrp30 in OS.…”

Section: Introductionmentioning

confidence: 99%

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells

Sapio

Nigro

Ragone

et al. 2020

Journal of Oncology

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AdipoRon (AdipoR) is the first synthetic molecule acting as a selective and potent adiponectin receptor agonist. Recently, the possible pharmacological use of AdipoR in different pathological conditions has been addressed. Interestingly, initial evidence suggests that AdipoR may have anticancer properties in different preclinical models, such as pancreatic and ovarian cancer. To our knowledge, so far no research has been directed at determining the impact of AdipoR on osteosarcoma, the most aggressive and metastatic bone malignancy occurring in childhood and adolescence age. Here, we investigate the possible antitumor effects of AdipoR in osteosarcoma cell lines. MTT and cell growth curve assays clearly indicate that AdipoR inhibits, at different extents, proliferation in both U2OS and Saos-2 osteosarcoma cell lines, the latter being more sensitive. Moreover, flow cytometry-based assays point out a significant G0/G1 phase accumulation and a contemporary S phase decrease in response to AdipoR. Consistent with the different sensitivity, a strong subG1 appearance in Saos-2 after 48 and 72 hours of treatment is also observed. The investigation of the molecular mechanisms highlights a common and initial ERK1/2 activation in response to AdipoR in both Saos-2 and U2OS cells. Interestingly, a simultaneous and dramatic downregulation of p70S6K phosphorylation, one of the main targets of mTORC1 pathway, has also been observed in AdipoR-treated Saos-2, but not in U2OS cells. Importantly, a strengthening of AdipoR-induced effects was reported upon everolimus-mediated mTORC1 perturbation in U2OS cells. In conclusion, our findings provide initial evidence of AdipoR as an anticancer molecule differently affecting various signaling pathways involved in cell cycle and cell death in osteosarcoma cells and encourage the design of future studies to further understand its pattern of activities.

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Section: Introductionmentioning

confidence: 99%

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells

Sapio

Nigro

Ragone

et al. 2020

Journal of Oncology

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“…Also, obesity is known to be a major risk of whole range of cardio vascular, metabolic and respiratory disorders (Mazzeo, 2016;Boulet, 2013.) Th e obese adolescent presents, in addition to the characteristics of an organic nature, mainly those of a psychological nature. Th e body transformation determined by age and the oft en negative judgments of peers frequently determine psychological problems with personality disorders and with attempts, oft en inappropriate, of compensation on the body of aff ective-relational disorders (Illiano et al, 2017). Furthermore, obesity it is oft en one of the factors of the conditions of discomfort in the adolescent age that slows down the process of social inclusion and it degrades the functionality of large body systems (Salome, King, & Berend, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Th e global approach to obesity (Mazzeo, 2016) is oft en diffi cult, caused by the multifactorial nature of the phenomenon. In the etiopathogenesis there are multiple factors, both environmental and psychological (Zametkin, 2004), both of a genetic nature (Illiano et al, 2017). Th e treatment of obesity cannot and should not be understood as a simple prescription of certain diets or a simple encouragement to perform motor-sports activities (Yazdani, Sharif, Elahi, Ebadi, & Hosseini, 2018).…”

Section: Introductionmentioning

confidence: 99%

Sports Activities in Obese Teenagers Improve Social Inclusion and Health

Montesano¹,

Mazzeo²

2019

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Obesity is known to be a major risk of whole range of cardio vascular, metabolic and respiratory disorders. The etiology of obesity can be genetic, hormonal and determine the central obesity (or visceral or android). It is characterized by the deposit of fat especially abdominal and recognizable by a waist-hip ratio of more than 0.85 in women and 0.95 in 'man, and the peripheral (or subcutaneous or gynoid) that shows a ratio of less than 0.85 in women and 0.95 in men. The research was carried out in order to monitor and improve the correct use of the respiratory function of obese adolescents by developing a sports program aimed at reducing body weight and enhancing motor skills on 60 subjects (30 males and 30 females) aged between 14 and 16 years for a period of eight months. Results showed a reduction in body weight for almost all participants. For 26 subjects, the reduction was around 10%, while for others it was around 8%. Only 8 subjects did not signifi cantly change their weight. The improvement of the motor program, on average, was about 9.5%. The phenomenon of obesity is often one of the factors of discomfort conditions in adolescence that slows down the process of social inclusion and highlights "paramorhism" that has negative eff ect on the respiratory function. Sport is one of the most important activities to combat the problem of weight gain because, through the rules of sports disciplines, it favors the acquisition of correct lifestyles.

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“…Molecular profiling technologies to assess DNA, RNA, protein and metabolites have led to better understanding of the molecular basis of cancer, with identification of new disease markers (28)(29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Biomarkersmentioning

confidence: 99%