Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity

Kyriakou, Theodosios; Collins, Laura; Spencer-Jones, Nicola J.; Malcolm, Claire; Wang, Xiaoling; Snieder, Harold; Swaminathan, R.; Burling, Keith; Hart, Deborah; Spector, Tim D.; O’Dell, Sandra D.

doi:10.1007/s10038-008-0303-1

Cited by 73 publications

(80 citation statements)

References 43 publications

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“…Two ADIPOQ promoter SNPs, rs17300539 (211391G.A) and rs266729 (211377C.G), have been investigated frequently in functional experiments (9,11,12,31) due to their strong reproducible correlations with circulating adiponectin and to the potential role of the promoter region in regulating gene transcriptional activity.…”

Section: Discussionmentioning

confidence: 99%

“…Among ADIPOQ variants identified by a candidate gene approach, the widely reported promoter SNP rs17300539 (211391 G.A) with potential biological function (16) was monomorphic in the CLHNS mothers. Four other candidate gene variants rs266729 (211377 C.G), rs2241766 (+45 T.G), rs1501299 (+276 G.T) and rs1063537 (11,13,16) were marginally associated with adiponectin (P ¼ 0.018, 0.0077, 0.059 and 0.017, respectively). The GWAS SNP rs3774261 (23) displayed significant association in the same direction in CLHNS (P ¼ 7.0 × 10 25 ).…”

Section: Adiponectin Association With Previously Reported Snpsmentioning

confidence: 99%

“…Encoding the adiponectin protein, the gene ADIPOQ has been widely investigated for variants associated with circulating adiponectin. Several SNPs including rs17300539 (211391G.A), rs2241766 (+45T.G) and rs1501299 (+276G.T) have been reproducibly reported to be associated with circulating adiponectin (11)(12)(13)(14)(15)(16). Two reports suggested the presence of distinct association signals for adiponectin levels represented by 5 ′ -promoter SNP rs17300539 and either rs6773957 (17) or rs182052 (18), and a gene-wide tagSNP investigation revealed that two haplotype blocks mapping to the ADIPOQ promoter and the relevant exons showed association with adiponectin (19).…”

Section: Introductionmentioning

confidence: 99%

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Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

Wu¹,

Lange

et al. 2010

Human Molecular Genetics

116

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Adiponectin is an adipocyte-secreted protein involved in a variety of metabolic processes, including glucose regulation and fatty acid catabolism. We conducted a genome-wide association study to investigate the genetic loci associated with plasma adiponectin in 1776 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). Our strongest signal for adiponectin mapped to the gene CDH13 (rs3865188, P ≤ 7.2 × 10−16), which encodes a receptor for high-molecular-weight forms of adiponectin. Strong association was also detected near the ADIPOQ gene (rs864265, P = 3.8 × 10−9) and at a novel signal 100 kb upstream near KNG1 (rs11924390, P = 7.6 × 10−7). All three signals were also observed in 1774 young adult CLHNS offspring and in combined analysis including all 3550 mothers and offspring samples (all P ≤ 1.6 × 10−9). An uncommon haplotype of rs11924390 and rs864265 (haplotype frequency = 0.050) was strongly associated with lower adiponectin compared with the most common C–G haplotype in both CLHNS mothers (P = 1.8 × 10−25) and offspring (P = 8.7 × 10−32). Comprehensive imputation of 2653 SNPs in a 2 Mb region using as reference combined CHB, JPT and CEU haplotypes from the 1000 Genomes Project revealed no variants that perfectly tagged this haplotype. Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1–ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos.

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Section: Discussionmentioning

confidence: 99%

Section: Adiponectin Association With Previously Reported Snpsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

Wu¹,

Lange

et al. 2010

Human Molecular Genetics

116

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“…AdipoQ rs1501259 T allele carriers were associated with high adiponectin levels in Italian population (14,30) and, just on the opposite, G allele carriers were associated with high adiponectin levels in Greek population (16) or significant associations were not found in a third group of studies (13). AdipoQ rs822391 T allele carriers were related to an increased risk for CVD in Korean volunteers (20). G=0.01 *1 subject failed to be genotyped for rs9939609 ** 1 subject failed to be genotyped for rs1501299 Table 4).…”

Section: Resultsmentioning

confidence: 99%

The FTO rs9939609, ADIPOQ rs1501299, rs822391, and ADIPOR2 rs16928662 Polymorphisms Relationship to Obesity and Metabolic Syndrome in Bulgarian Sample

Vankova

Radanova

Kiselova-Kaneva

et al. 2012

Biotechnology & Biotechnological Equipment

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“…In addition, the area of the genome that harbors ADIPOQ has been identified by GWAS to be a susceptibility locus for risk of metabolic syndrome, T2DM and CVD (2). Studies have shown that ADIPOQ has some influence on adiponectin levels and plasma isoform levels, which are themselves related to modulation of the risk of developing T2DM and CVD (9).…”

Section: Sumáriomentioning

confidence: 99%

ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease?

Oliveira

Giuffrida

Crispim

et al. 2011

Arq Bras Endocrinol Metab

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SUMMARYPlasma adiponectin and the coding gene for adiponectin, ADIPOQ, are thought to explain part of the interaction between obesity, insulin resistance, type 2 diabetes (T2DM) and coronary artery disease (CAD). Here, we illustrate the role that adiponectin and ADIPOQ variants might play in the modulation of CAD, especially in the occurrence of hyperglycemia. Recent evidence suggests that total and high molecular weight (HMW) adiponectin levels are apparent markers of better cardiovascular prognosis in patients with low risk of CAD. However, in subjects with established or high risk of CAD, these levels are associated with poorer prognosis. We also provide recent evidences relating to the genetic control of total and HMW adiponectin levels, especially evidence regarding ADIPOQ. Accumulated data suggest that both adiponectin levels and polymorphisms in the ADIPOQ gene are linked to the risk of CAD in patients with hyperglycemia, and that these associations seem to be independent from each other, even if adiponectin levels are partly dependent on ADIPOQ. Arq Bras Endocrinol Metab. 2011;55(7):446-54 Keywords Total adiponectin; HMW adiponectin; ADIPOQ; polymorphisms; coronary artery disease; type 2 diabetes mellitus SUMáRio Os níveis plasmáticos de adiponectina e o gene codante desta proteína, ADIPOQ, parecem explicar parte da interação de doenças como obesidade, resistência à insulina, diabetes melito tipo 2 (DM2) e doença arterial coronariana (DAC). Apresentamos as evidências do papel tanto dos níveis de adiponectina quanto das variantes no ADIPOQ na modulação da DAC, sobretudo na presença de hiperglicemia. Estudos recentes sugerem que níveis de adiponectina total e de alto peso molecular (HMW) são marcadores de bom prognóstico DAC, sobretudo em pacientes de baixo risco cardiovascular, enquanto nos pacientes de alto risco ou com doença já estabelecida podem se associar com pior prognóstico. Apresentamos também as evidências em relação ao possível controle genético dos níveis circulantes de adiponectina, tanto total quanto da isoforma de alto peso molecular, sobretudo em relação ao ADIPOQ. A análise global dos dados sugere que tanto os níveis circulantes de adiponectina quanto polimorfismos no gene ADIPOQ estão implicados na evolução de DAC em pacientes com hiperglicemia e que essas associações podem existir de forma independente. Arq Bras Endocrinol Metab. 2011;55(7):446-54 Descritores Adiponectina total; adiponectina de alto peso molecular; ADIPOQ; polimorfismo; doença arterial coronariana; diabetes melito tipo 2 review

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Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity

Cited by 73 publications

References 43 publications

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1–ADIPOQ

The FTO rs9939609, ADIPOQ rs1501299, rs822391, and ADIPOR2 rs16928662 Polymorphisms Relationship to Obesity and Metabolic Syndrome in Bulgarian Sample

ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease?

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