Adiponectin Gene Polymorphisms and Type 2 Diabetes among Singaporean Chinese Adults

Toy, Wan Ching; Liu, Jing; Cheng, Anton

doi:10.4172/2155-6156.1000152

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Adiponectin is expressed in adipose tissue and low levels of it may cause reduction of fatty acid oxidation, elevated plasma glucose and insulin resistance, ultimately leading to T2DM [ 50 ]. The rs2241766-G of ADIPOQ gene significantly associated in this study was found to be associated with T2DM in another sample of south Indians [ 51 ] and in different other ethnic groups outside India—in Japanese [ 52 ], Singaporean Chinese [ 53 ], Han Chinese [ 54 ] and Iraqi populations [ 55 ]. Furthermore, the in-silico analysis also revealed that + 45 T>G polymorphism causes a synonymous change (G15G) and modulates the expression of adiponectin gene via affecting the splicing machinery [ 56 ].…”

Section: Discussionmentioning

confidence: 77%

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

et al. 2021

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Background The genetic association studies of type 2 diabetes mellitus (T2DM) hitherto undertaken among the Indian populations are grossly inadequate representation of the ethnic and geographic heterogeneity of the country. In view of this and due to the inconsistent nature of the results of genetic association studies, it would be prudent to undertake large scale studies in different regions of India considering wide spectrum of variants from the relevant pathophysiological pathways. Given the reproductive dysfunctions associated with T2DM, it would be also interesting to explore if some of the reproductive pathway genes are associated with T2DM. The present study is an attempt to examine these aspects in the southern Indian population of Hyderabad. Methods A prioritized panel of 92 SNPs from a large number of metabolic and reproductive pathway genes was genotyped on 500 cases and 500 controls, matched for ethnicity, age and BMI, using AGENA MassARRAYiPLEX™ platform. Results The allelic association results suggested 14 SNPs to be significantly associated with T2DM at P ≤ 0.05 and seven of those—rs2241766-G (ADIPOQ), rs6494730-T (FEM1B), rs1799817-A and rs2059806-T (INSR), rs11745088-C (FST), rs9939609-A and rs9940128-A (FTO)—remained highly significant even after correction for multiple testing. A great majority of the significant SNPs were risk in nature. The ROC analysis of the risk scores of the significant SNPs yielded an area under curve of 0.787, suggesting substantial power of our study to confer these genetic variants as predictors of risk for T2DM. Conclusions The associated SNPs of this study are known to be specifically related to insulin signaling, fatty acid metabolism and reproductive pathway genes and possibly suggesting the role of overlapping phenotypic features of insulin resistance, obesity and reproductive dysfunctions inherent in the development of diabetes. Large scale studies involving gender specific approach may be required in order to identify the precise nature of population and gender specific risk profiles for different populations, which might be somewhat distinct.

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Section: Discussionmentioning

confidence: 77%

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

et al. 2021

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“…This phenomenon might result from heterogeneity among racial groups; their impact on T2DM susceptibility are uncertain and worthy of follow‐up studies. The inconsistency of MAF was observed in different ethnic populations for both selected polymorphisms (Arikoglu et al., ; Hara et al., ; Hu et al., ; Li et al., ; Mohammadzadeh et al., ; Ramya et al., ; Toy, Liu, Cheng, Tan, & Lau, ). In this scenario, the present study was designed to establish the potential relationship of ADIPOQ −3971A/G (rs822396) and +276G/T (rs1501299) polymorphism with T2D subjects in a North Indian population (Punjab region).…”

Section: Discussionmentioning

confidence: 99%

Association study of the single‐nucleotide polymorphisms −3971G/A and +276G/T in the adiponectin gene with type 2 diabetes in a North Indian Punjabi population

Bains

Kaur

Badaruddoza

2019

Annals of Human Genetics

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Objective To investigate the role of ADIPOQ gene variants (−3971G/A rs822396 and +276G/T rs1501299) with type 2 diabetes risk in a North Indian Punjabi population. Methods Adiponectin is one of the most abundant circulating adipocytokines in the human body that plays an important role in the metabolic processes and positively regulates energy homeostasis and insulin secretion. Several studies have provided the evidence of adiponectin gene polymorphisms association with type 2 diabetes mellitus (T2DM) in different ethnic populations. A total of 616 subjects including 316 T2DM patients and 300 normal healthy controls from Punjab were genotyped for ADIPOQ polymorphisms (rs822396 and rs1501299) by using a polymerase chain reaction–based restriction fragment length polymorphism (PCR‐RFLP) technique. Anthropometric, physiometric, and biochemical measurements were taken from each participant. Results Genotypic frequencies were significantly different in T2DM subjects and healthy controls for both polymorphisms (rs822396 and rs1501299). The risk genotype GG of −3971A/G and TT of +276G/T conferred an approximately twofold risk towards the development of T2DM and were found to be significantly higher in T2DM cases than control subjects (p = 0.006 and p = 0.019, respectively, after the Bonferroni correction). The recessive model of the ADIPOQ polymorphism rs822396 was significantly shown to confer a 3.63‐fold risk towards type 2 diabetes after adjusting for confounding factors and Bonferroni correction [odds ratio (OR): 3.63 (1.20–10.96), p = 0.022]. rs1501299 gave a 3.82‐fold risk towards development of T2DM but was not statistically significant after Bonferroni correction [OR: 3.82 (1.16–12.55), p = 0.027]. Meta‐analysis also illustrated the overall effect of the minor allele of rs822396 (−3971A/G) polymorphism, providing a greater risk for the T2DM development. Conclusion Thus, we concluded on the basis of observed results that the ADIPOQ gene polymorphisms rs822396 and rs1501299 plays an important role in the development of type 2 diabetes in North Indian Punjabi population.

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“…Spanish individuals with both genotypes may jointly predispose to low adiponectin concentrations of the TNF-α and SNP 45 G allele of the adiponectin gene, potentially facilitating the production of impaired glucose tolerance or T2DM [ 72 ]. Adiponectin rs2241766 (SNP45T > G) polymorphism is closely linked to T2DM prevalence in South Indian population [ 6 ] and Singaporean Chinese adults [ 73 ]. The rs2241766 SNP (SNP45 T/G) of adiponectin gene is a risk factor for the development of T2DM in Iraqi population [ 74 ].…”

Section: Adiponectin Gene Polymorphisms In Different Types Of Diabetes Mellitusmentioning

confidence: 99%

Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review

Howlader

Sultana

Akter

et al. 2021

Heliyon

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Diabetes is currently a growing concern of the age. Prevention and treatment of diabetes is a global health priority. Adiponectin is an adipocyte derived protein hormone that enhances insulin sensitivity and ameliorates diabetes by enhancing fatty acid oxidation and glucose uptake in skeletal muscle and reducing glucose production in the liver. Low serum adiponectin concentrations are associated with diabetes, central obesity, insulin resistance and metabolic syndrome. Adiponectin gene is located on chromosome 3q27, where a locus of susceptibility to diabetes was mapped. Several cross-sectional studies showed that single nucleotide polymorphisms (SNPs) in adiponectin gene (ADIPOQ) were associated with diabetes. SNPs in ADIPOQ help in assessing the association of common variants with levels of adiponectin and the risk of diabetes. Two common SNPs, rs2241766 and rs1501299, have been linked significantly to type 1 diabetes mellitus which endow the world with a block of haplotypes. Experimental evidences also suggest that rs1501299, rs2241766, rs266729, rs17366743, rs17300539, rs182052, rs822396, rs17846866, rs3774261 and rs822393 are significantly associated with type 2 diabetes mellitus which is the predominant form of the disease. In addition, rs2241766 and rs266729 are extensively associated with gestational diabetes, a condition that develops in women during pregnancy. Therefore not a particular single mutation but a number of SNPs in adiponectin gene could be a risk factor for developing diabetes among the individuals worldwide. This study firmly suggests that adiponectin plays a crucial role in the pathogenesis of type 1, type 2 and gestational diabetes mellitus.

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Adiponectin Gene Polymorphisms and Type 2 Diabetes among Singaporean Chinese Adults

Cited by 4 publications

References 18 publications

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

Association study of the single‐nucleotide polymorphisms −3971G/A and +276G/T in the adiponectin gene with type 2 diabetes in a North Indian Punjabi population

Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review

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