Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population

Hussain, Majid Kadhum; Deli, Falah Abdulhasan; Algenabi, Abdul Hussein A.; Abdul-Rudha, Khalid H.

doi:10.1016/j.gene.2018.03.087

Cited by 28 publications

(11 citation statements)

References 32 publications

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“…Adiponectin is expressed in adipose tissue and low levels of it may cause reduction of fatty acid oxidation, elevated plasma glucose and insulin resistance, ultimately leading to T2DM [ 50 ]. The rs2241766-G of ADIPOQ gene significantly associated in this study was found to be associated with T2DM in another sample of south Indians [ 51 ] and in different other ethnic groups outside India—in Japanese [ 52 ], Singaporean Chinese [ 53 ], Han Chinese [ 54 ] and Iraqi populations [ 55 ]. Furthermore, the in-silico analysis also revealed that + 45 T>G polymorphism causes a synonymous change (G15G) and modulates the expression of adiponectin gene via affecting the splicing machinery [ 56 ].…”

Section: Discussionmentioning

confidence: 83%

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

et al. 2021

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Background The genetic association studies of type 2 diabetes mellitus (T2DM) hitherto undertaken among the Indian populations are grossly inadequate representation of the ethnic and geographic heterogeneity of the country. In view of this and due to the inconsistent nature of the results of genetic association studies, it would be prudent to undertake large scale studies in different regions of India considering wide spectrum of variants from the relevant pathophysiological pathways. Given the reproductive dysfunctions associated with T2DM, it would be also interesting to explore if some of the reproductive pathway genes are associated with T2DM. The present study is an attempt to examine these aspects in the southern Indian population of Hyderabad. Methods A prioritized panel of 92 SNPs from a large number of metabolic and reproductive pathway genes was genotyped on 500 cases and 500 controls, matched for ethnicity, age and BMI, using AGENA MassARRAYiPLEX™ platform. Results The allelic association results suggested 14 SNPs to be significantly associated with T2DM at P ≤ 0.05 and seven of those—rs2241766-G (ADIPOQ), rs6494730-T (FEM1B), rs1799817-A and rs2059806-T (INSR), rs11745088-C (FST), rs9939609-A and rs9940128-A (FTO)—remained highly significant even after correction for multiple testing. A great majority of the significant SNPs were risk in nature. The ROC analysis of the risk scores of the significant SNPs yielded an area under curve of 0.787, suggesting substantial power of our study to confer these genetic variants as predictors of risk for T2DM. Conclusions The associated SNPs of this study are known to be specifically related to insulin signaling, fatty acid metabolism and reproductive pathway genes and possibly suggesting the role of overlapping phenotypic features of insulin resistance, obesity and reproductive dysfunctions inherent in the development of diabetes. Large scale studies involving gender specific approach may be required in order to identify the precise nature of population and gender specific risk profiles for different populations, which might be somewhat distinct.

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Section: Discussionmentioning

confidence: 83%

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

et al. 2021

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“…During pregnancy, the plasmatic levels of this hormone are normally decreased; however, such levels are even lower in the presence of this variation ( Huang et al, 2019 ). In fact, lower levels of adiponectin could be related to an increase in the formation of dense LDL particles ( Lara-Castro et al, 2007 ), and to an increase in the expression of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-8 ( Hussain et al, 2018 ).…”

Section: Genetic Factors Associated With Gestational Diabetes Mellitu...mentioning

confidence: 99%

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

et al. 2022

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Gestational Diabetes Mellitus (GDM) is a highly prevalent maternal pathology characterized by maternal glucose intolerance during pregnancy that is, associated with severe complications for both mother and offspring. Several risk factors have been related to GDM; one of the most important among them is genetic predisposition. Numerous single nucleotide polymorphisms (SNPs) in genes that act at different levels on various tissues, could cause changes in the expression levels and activity of proteins, which result in glucose and insulin metabolism dysfunction. In this review, we describe various SNPs; which according to literature, increase the risk of developing GDM. These SNPs include: (1) those associated with transcription factors that regulate insulin production and excretion, such as rs7903146 (TCF7L2) and rs5015480 (HHEX); (2) others that cause a decrease in protective hormones against insulin resistance such as rs2241766 (ADIPOQ) and rs6257 (SHBG); (3) SNPs that cause modifications in membrane proteins, generating dysfunction in insulin signaling or cell transport in the case of rs5443 (GNB3) and rs2237892 (KCNQ1); (4) those associated with enzymes such as rs225014 (DIO2) and rs9939609 (FTO) which cause an impaired metabolism, resulting in an insulin resistance state; and (5) other polymorphisms, those are associated with growth factors such as rs2146323 (VEGFA) and rs755622 (MIF) which could cause changes in the expression levels of these proteins, producing endothelial dysfunction and an increase of pro-inflammatory cytokines, characteristic on GDM. While the pathophysiological mechanism is unclear, this review describes various potential effects of these polymorphisms on the predisposition to develop GDM.

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“…In addition, genetic predisposition, obesity, and lack of physical activity are risk factors for developing T2DM (Hussain, 2018). Another study in Baghdad, Iraq found that factors that contribute to glycemic status in T2DM include older age, diet alone, and low physical activity (Al-Hasnawi, MY, Hazizi, & Rafi, 2015).…”

Section: Other Factors Influencing Diabetes Control In Iraqmentioning

confidence: 99%

narrative review of nutritional status among iraqi adults with type 2 diabetes

Mahmood¹,

Yusof²,

Sallehuddin³

et al. 2022

ijhs

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Type 2 diabetes is a global public health problem especially in middle east countries and Iraq has not spared from this pandemic. The prevalence in Iraq. and rank in Middle East. Beside increasing in prevalence- also poor glucose control. Nutrition plays a critical role. This paper narratively review variables that affect reduce the incidence of T2DM in Iraq and affect nutritional status among Iraqi withT2DM. The factors contribute to T2DM were high rates of obesity and overweight, as well as levels of body fat indicate a high prevalence of poor glycemic control. Likewise, levels of physical activity are low among older Iraqis.

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Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population

Cited by 28 publications

References 32 publications

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

The genetic susceptibility profile of type 2 diabetes and reflection of its possible role related to reproductive dysfunctions in the southern Indian population of Hyderabad

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus

narrative review of nutritional status among iraqi adults with type 2 diabetes

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