Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link

Ljubić, Spomenka; Boras, Jozo; Jazbec, Anamarija; Lovrenčić, Marijana Vučić; Vidjak, Vinko; Jurišić‐Eržen, Dubravka; Mileta, Dean

doi:10.25011/cim.v32i4.6618

Cited by 12 publications

(14 citation statements)

References 36 publications

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“…The study observed no significant (p>0.05) differences in the serum adiponectin levels of the diabetics and the non-diabetics population studied. Similar observation has been reported by a previous study 12 between type 2 diabetics and controls. Type 2 diabetic subjects recruited in this study have been on sulphonyurea treatment from the time of diagnosis to time analysis was carried out.…”

Section: Discussionsupporting

confidence: 92%

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

et al. 2013

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Background: Adiponectin has been associated with insulin resistance and dyslipidemia in Type 2 diabetes, though the mechanism of association is still uncertain. The adiponectin levels and lipid profile in relation to glycemic control were investigated in type 2 diabetics. Methods: Forty two diabetic subjects (35-64 years) and 33 age-matched non-diabetic subjects were recruited into this case control study. Socio-demographic characteristics, anthropometric indices and blood pressure were obtained. Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein, (HDL), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) were estimated using colorimetric methods, atherogenic index (AI) was calculated, while serum adiponectin was determined by ELISA method. Results: Adiponectin levels of type 2 diabetics were not significantly different from the non-diabetics studied (p>0.05). Higher TG levels were observed in diabetics with poor glycemic control compared with those with good glycemic control (p<0.05). Hypertensive diabetics have higher TC and lower HDL-C levels compared with non hypertensive diabetics (p<0.05). Adiponectin correlated positively with HDL-C (r = 0.739, p = 0.01) and negatively with AI (r = -0.539, p = 0.001) only in the non diabetic group. No significant differences were observed in the adiponectin levels in relation with gender, duration of diabetes and glycemic state (p>0.05). Conclusion: Type 2 diabetics do not have lower adiponectin levels. Gender, duration of diabetes and glycemic control does not seem to exert any influence on adiponectin levels in type 2 diabetes. Adiponectin may be associated with reduced risk of atherosclerosis through its effects on HDL cholesterol metabolism. [Int J Res Med Sci 2013; 1(4.000): 563-570

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Section: Discussionsupporting

confidence: 92%

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

et al. 2013

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“…But our results are contrary to Lindström et al (49) who reported a non-significant correlation of adiponectin with TAG but a direct association with TC. In our results, ACR was not correlated to adiponectin, which is supported by the results of Ljubic et al (50). …”

Section: Discussionsupporting

confidence: 91%

CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

Hashim

Ali

Emara³

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundIn this study, we investigated the relationship of adiponectin with bone marker changes in Egyptian children and adolescents with T1DM and the effect of disease duration on these markers, as well as the possible correlations between adiponectin and bone markers in these patients.MethodsSixty Egyptian children and adolescent patients with T1DM were studied. Serum adiponectin and collagen breakdown products (cross-linked C-terminal telopeptide of collagen type l »CTX«) were measured and compared to the results of 20 age-matched healthy controls.ResultsAfter adjustment for age, BMI, Tanner stage and gender; (total) adiponectin was significantly higher in all T1DM patients. Serum level of CTX and 25(OH)D showed a marked decrease in diabetics with disease duration > 5 years. Serum level of (total) calcium and inorganic phosphorus (Pi) did not show significant difference from control. CTX was inversely correlated to FBG and T1DM duration. Pi was inversely, while 25(OH)D was directly correlated to FBG. Total calcium showed an inverse correlation with HbA1c. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM.ConclusionsAdiponectin showed no correlation with either CTX or bone homeostatic indices. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. We recommend further investigation of adiponectin isoforms in a population-based study, to establish a good age- and sex-related reference.

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“…[25]. Another study of Ljubic et al also reported the similar result [26]. Furthermore, a crosssectional study of Streja et al elucidated no association of hs-CRP with the complications of diabetes [27].…”

Section: Discussionmentioning

confidence: 72%

Study of Serum Adiponectin and High Sensitivity C-Reactive Protein in Diabetic Patients

Shreshtha

Sharma

Kumar

et al. 2018

Asian J Pharm Clin Res

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Objectives: Adiponectin, a major cytokine from adipose tissue, and high sensitivity C-reactive protein (hs-CRP), well-established markers of inflammation are known to be associated with increased risk of cardiovascular disorders (CVD). Therefore the objective of our study was to evaluate the levels of these parameters and determine their correlation with glycemia to assess the cardiovascular risks in the patients with Type 2 diabetes mellitus.Methods: This study was conducted in the Department of Biochemistry, Santosh Medical College, Ghaziabad, with 25 Type 2 diabetic patients and 25 age and sex-matched controls. Ethical clearance from the institution and informed consent from the patients were taken before the study. Adiponectin was analyzed by enzyme-linked immunoadsorbent assay, and blood sugar and CRP were estimated by the kit based method.Results: Fasting blood sugar (FBS, 158.2±37.2) and hs-CRP (3.97±1.54) were significantly high, adiponectin was significantly low in the patients with diabetes compared to controls (80.52±9.72, 1.27±0.75, and 10.78±1.69, respectively, p<0.05). Adiponectin showed a negative correlation with FBS (r=−0.427) and hs-CRP (r=−0.336), but the correlation was significant only in case of FBS (p<0.05). hs-CRP positively correlated with FBS (r=0.568) and was statistically significant.Conclusion: The results of our study further support the role of adiponectin and hs-CRP as a predictive biomarker of CVD risks in the patients suffering from Type 2 diabetes.

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Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link

Cited by 12 publications

References 36 publications

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

Study of Serum Adiponectin and High Sensitivity C-Reactive Protein in Diabetic Patients

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