Adiponectin in psoriasis and its comorbidities: a review

Renju, Bai; Wu, Ruifang; Zhang, Peng; Fu, Siqi

doi:10.1186/s12944-021-01510-z

Cited by 16 publications

(10 citation statements)

References 142 publications

(160 reference statements)

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“…Noteworthy, dissimilar to the above mentioned autoim mune conditions, adiponectin can act on keratinocytes and naïve Tcells and therefore has its rather an antiinflamma tory role in the pathogenesis of one more autoimmune dis order psoriasis by increasing the production of IL10, while inhibiting the production and activity of IL2, Il6, IL8, IL17, IL22, TNFα and IFNγ [162]. Moreover, adiponectin similar ly to adipocytes is expressed in human sebaceous glands affecting the homeostasis of the dermis.…”

Section: Adiponectin and Various Diseasesmentioning

confidence: 99%

“…Patients with pso riasis have lower plasma adiponectin levels which thereby may lead to increased production of proinflammatory cy tokines and lack of antiinflammatory ones which eventual ly worsen the severity of their skin lesions. In keratinocytes the decrease in adiponectin levels has been shown to result in the reduced E2F1 gene activation through AMPK pathway promoting the proliferation of keratinocytes and inducing abnormal cell apoptosis thus interacting with the infiltration of the inflammatory response and leading to psoriasis [162].…”

Section: Adiponectin and Various Diseasesmentioning

confidence: 99%

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Adiponectin: a pleiotropic hormone with multifaceted roles

Shklyaev

Мельниченко

Волеводз

et al. 2021

Probl Endokrinol (Mosk)

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Adipose tissue mostly composed of different types of fat is one of the largest endocrine organs in the body playing multiple intricate roles including but not limited to energy storage, metabolic homeostasis, generation of heat, participation in immune functions and secretion of a number of biologically active factors known as adipokines. The most abundant of them is adiponectin. This adipocite-derived hormone exerts pleiotropic actions and exhibits insulin-sensitizing, antidiabetic, anti-obesogenic, anti-inflammatory, antiatherogenic, cardio- and neuroprotective properties. Contrariwise to its protective effects against various pathological events in different cell types, adiponectin may have links to several systemic diseases and malignances. Reduction in adiponectin levels has an implication in COVID-19-associated respiratory failure, which is attributed mainly to a phenomenon called ‘adiponectin paradox’. Ample evidence about multiple functions of adiponectin in the body was obtained from animal, mostly rodent studies. Our succinct review is entirely about multifaceted roles of adiponectin and mechanisms of its action in different physiological and pathological states.

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Section: Adiponectin and Various Diseasesmentioning

confidence: 99%

Section: Adiponectin and Various Diseasesmentioning

confidence: 99%

Adiponectin: a pleiotropic hormone with multifaceted roles

Shklyaev

Мельниченко

Волеводз

et al. 2021

Probl Endokrinol (Mosk)

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“…Psoriasis as a chronic systemic inflammatory disease that shares pro-inflammatory mechanisms with obesity, including Th1 cytokines [interferon-γ, interleukin (IL)-2, IL-12, and tumor necrosis factor (TNF)-α] ( 35 ). More recently, the family of adipokines have been involved in the obesity-driven inflammation in psoriasis ( 36 ). Obesity is an independent risk factor associated with psoriasis severity and response to systemic therapy (i.e., methotrexate, cyclosporine, apremilast, and biologic agents) ( 37 – 39 ).…”

Section: Chronic Skin Conditions Influenced By Comorbid Obesitymentioning

confidence: 99%

The Link Between Obesity and the Skin

2022

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Obesity as a multi-organ disease that affects the entire human organism. Notably, the skin is no exclusion from this postulate. Skin changes in obese patients have been widely studied with regards to mechanical friction, skin infections, and skin hypertrophic conditions, such as acanthosis nigricans and, most commonly, fibromas (skin tags). Almost 60–70% of obese patients present with a variety of skin changes. Herein, we discuss our own experience and review the complex skin changes in obesity. The role of metabolic syndrome and obesity are responsible for the epidemiological prevalence and are involved in the pathogenesis of chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, and skin malignancies. Here, we comment on the role of nutritional interventions in these patients as it has been proven that low-calorie diet and weight loss is related to improvement of inflammatory skin diseases. The readership of this paper will receive up-to-date overview on the connection between obesity and the skin that is of a practical importance to any clinician working in the field.

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“…Adiponectin plays a crucial role in controlling psoriasiform dermatosis by reducing Th17 cell differentiation, restraining glycolysis in an AMPK dependent fashion, thus tightly regulating their nutritional demands and metabolic function [91][92][93]. Psoriasis patients with or without metabolic abnormalities exhibit significant hypoadiponectinemia (negatively corelated with psoriasis area severity index, PASI) and hyperleptinemia with leptin resistance (positively corelated with PASI), that contribute to the development of the metabolic syndrome.…”

Section: Obesity Systemic Immunometabolism and Psoriasismentioning

confidence: 99%

Th17/IL-17, Immunometabolism and Psoriatic Disease: A Pathological Trifecta

Chhabra¹,

Sahu²,

Sharma³

et al. 2022

Psoriasis - New Research

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The burgeoning arena of immunometabolism provides evidence of how cellular, as well as local (tissue)/systemic metabolic pathways, are playing an important role in controlling immunity and inflammation. An intricate and elaborate network of various metabolic circuits specifically glycolysis, fatty acid oxidation and synthesis and amino acid metabolism precisely generate metabolites that rewire the immune response. Psoriasis is a chronic progressive self-perpetuated “IL-17-centric” inflammatory disease characterized by the co-existence of autoimmune and autoinflammatory pathways. Metabolic responses, governed by oxygen levels, nutrient availability, growth factors, cytokines, AMP/ATP ratios and amino acids, play a pivotal role in programming Th17 cell fate determination. Understanding the intricate interactions and complex interplay of molecular mechanisms responsible for Th17 cell metabolic rewiring, an important determinant of Th17 cell plasticity and heterogeneity, holds the potential to reshape psoriatic therapeutics in ways currently unimagined. This chapter entails with most recent updates on major cellular and systemic metabolic pathways regulating differentiation of Th17 cells as well their cross-talk with intracellular signaling mediators and also sheds light on how dysregulation of these pathways can be responsible for immune impairment and development of psoriatic disease. A better understanding of these metabolic processes could unveil an intriguing leverage point for therapeutic interventions to modulate metabolic programming and Th17 cell responses in this multi-systemic inflammatory disease.

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Adiponectin in psoriasis and its comorbidities: a review

Cited by 16 publications

References 142 publications

Adiponectin: a pleiotropic hormone with multifaceted roles

Adiponectin: a pleiotropic hormone with multifaceted roles

The Link Between Obesity and the Skin

Th17/IL-17, Immunometabolism and Psoriatic Disease: A Pathological Trifecta

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