Adiponectin is a better predictor of endothelial function of the coronary artery than HOMA-R, body mass index, immunoreactive insulin, or triglycerides

Okui, Hideki; Hamasaki, Shuichi; Ishida, Susumu; Kataoka, Tetsuro; Orihara, Koji; Fukudome, Tsuyoshi; Ogawa, Masanori; Oketani, Naoya; Saihara, Keishi; Shinsato, Takuro; Shirasawa, Takahiro; Mizoguchi, Etsuko; Kubozono, Takuro; Ichiki, Hitoshi; Ninomiya, Yuichi; Matsushita, Takehiko; Nakasaki, Mitsuhiro; Tei, Chuwa

doi:10.1016/j.ijcard.2007.03.116

Cited by 46 publications

(35 citation statements)

References 51 publications

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“…Adiponectin is the most abundant serum adipokine that has been recognized as a key regulator of insulin sensitivity, tissue inflammation, endothelial function, and lipid metabolism [2]. Moreover, a growing body of evidence suggests that hypoadiponectinemia may play a significant role in the development of Metabolic Syndrome [3].…”

Section: Introductionmentioning

confidence: 99%

Hypoadiponectinemia in Obesity: Association with Insulin Resistance

et al. 2012

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Obesity is risk factor for insulin resistance, diabetes, and other chronic diseases. Adiponectin, an adipose-specific protein with antiatherogenic and antiinflammatory effects, were found to be associated with obesity, type 2 diabetes, and insulin resistance. Our aim to identify possible relationships between circulating adiponectin and obesity as well as obesity related phenotypes. A total of 642, obese and non-obese individuals were included in this cross-sectional study. Hormone and glucose levels were estimated using standard protocols. The adiponectin levels showed a significant decrease with increasing quartiles of insulin resistance index. Subjects in lowest quartile of adiponectin level had a significantly higher risk than those in the highest quartile, with higher body mass index, waist circumference, blood pressure, percentage body fat, fat mass, fasting insulin, insulin resistance index, total cholesterol (p \ 0.001), low density lipoprotein-cholesterol (p = 0.001), very low density lipoprotein-cholesterol (p = 0.002), and Triglyceride (p = 0.002). The present study indicates that adiponectin is significantly associated with obesity, insulin resistance and other obesity related phenotypes.

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Section: Introductionmentioning

confidence: 99%

Hypoadiponectinemia in Obesity: Association with Insulin Resistance

et al. 2012

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“…In addition to its important role in metabolic process, adiponectin is involved in maintaining normal function of blood vessel and protects it against functional and structural disorders such as endothelial dysfunction, atherosclerosis and subsequent cardiovascular disease. Clinical observations have demonstrated that hypoadiponectinemia is closely related to endothelial dysfunction in peripheral arteries 9,10 and that plasma total adiponectin concentrations are inversely related to the risk of cardiovascular disease. 11,12,13 It is logical to deduce that the obesity-related downregulation of adiponectin may be the critical link to obesity-associated endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK–eNOS Pathway

et al. 2009

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Objective: Hypoadiponectinemia has been proved to be closely related to endothelial dysfunction in peripheral arteries and is thought to be an independent risk factor for cardiovascular disease. The objective of this study was to investigate whether adiponectin might independently improve endothelial dysfunction in aorta isolated from high-fat-diet-induced obese. SpragueDawley rat and to study the mechanism involved. Research Design and Subjects: Male Sprague-Dawley rats were fed with a regular or a high-fat diet for 6 weeks. The aorta was isolated, and vascular segments were incubated with vehicle or the globular adiponectin (globular domain (gAD); 2 mg ml À1 ) for 2 h. The effect of gAD on endothelial function and nitric oxide (NO) production was determined. Human aortic endothelial cells in primary culture were treated with vehicle or gAD (4 mg ml À1 ). The effect of gAD on the level of phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177, AMPK at Thr176 and Akt at Ser473 in endothelial cells were determined. Results: Severe endothelial dysfunction was observed in high-fat diet fed rat aortic segments. After gAd incubation, the endothelium-dependent relaxation was partly improved and total production of nitric oxide as result of enhanced eNOS activity was also increased. In the cultured endothelial cell line HUVEC, globular adiponectin increased the activity of eNOS through activating AMPK by stimulating its phosphorylation at Thr176 but not Akt. Conclusion:The demonstration in the current study that adiponectin reverses endothelial dysfunction through increasing NO production by eNOS phosphorylation, and decreasing NO inactivation by blocking superoxide production provides a new direction in the prevention of vascular injury in the obesity population.

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“…27 In contrast, various studies have demonstrated a direct effect of adiponectin on endothelial function at several levels. 28 Low adiponectin levels were associated with impaired CFR in women with a normal coronary angiography and were an independent predictor of impaired CFR. 29 The significant increase in adiponectin concentration in this study, which decreased inflammatory cytokines and interferes with TNF-α signaling, from baseline might have contributed to the greater restoration of microvascular integrity after acute ischemic injury in that group.…”

Section: Discussionmentioning

confidence: 91%