Adiponectin is associated with cardio-metabolic traits in Mexican children

Abstract

The adipocyte-derived adiponectin hormone bridges obesity and its cardio-metabolic complications. Genetic variants at the ADIPOQ locus, in ADIPOR1 , and ADIPOR2 have been associated with adiponectin concentrations and cardio-metabolic complications in diverse ethnicities. However, no studies have examined these associations in Mexican children. We recruited 1 457 Mexican children from Mexico City. Six genetic variants in or near ADIPOQ (rs182052, rs2241766, rs266729, rs822393), ADIPOR1 (rs10920533), and ADIPOR2 (rs11061971) were genotyped. Associations between serum adiponectin, genetic variants, and cardio-metabolic traits were assessed using linear and logistic regressions adjusted for age, sex, and recruitment center. Serum adiponectin concentration was negatively associated with body mass index, waist to hip ratio, low-density lipoprotein cholesterol, total cholesterol, triglycerides, fasting glucose, fasting insulin, homeostatic model assessment of insulin resistance, dyslipidemia and overweight/obesity status (7.76 × 10 −40 ≤ p ≤ 3.00 × 10 −3 ). No significant associations between genetic variants in ADIPOQ , ADIPOR1 , and ADIPOR2 and serum adiponectin concentration were identified (all p ≥ 0.30). No significant associations between the six genetic variants and cardio-metabolic traits were observed after Bonferroni correction (all p < 6.9 × 10 −4 ). Our study suggests strong associations between circulating adiponectin concentration and cardio-metabolic traits in Mexican children.

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

“…Regarding biochemical parameters, total-adiponectin had the strongest inverse correlation respect to HMW adiponectin, with glycaemia, followed by number of MetS components, HOMA-IR and insulin concentration. Similar findings have been described, where total adiponectin had a significant inverse relation with HOMA-IR and obesity, and its low concentration was an essential determinant of insulin sensitivity and HDL in children and may predict type 2 diabetes (7,29,32,34,35). No significant correlation was found for biochemical parameters related to fat metabolism (e.g., TG, HDL-C, LDL-C and TChol), probably due to the young age of the population and the pathophysiology of MetS (24,36).…”

“…The increase in childhood obesity worldwide is recognized as one of the most severe public health problems. The evidence of the association between childhood obesity and parameters of MetS is increasing (7,16,17). Adipocytokines and genetic background are known to be important in the pathogenesis of MetS (18,19).…”

“…A protective role of adiponectin is evident early in life and compromised in youth-onset obesity, and low concentrations could be considered a risk factor (7,32,34). It has been suggested that low levels of adiponectin are involved in the association between childhood obesity and adult atherosclerosis (41).…”

“…In Japanese children, HMW adiponectin was inversely correlated with obesity and insulin resistance (6). Although the Mexican population is a heterogeneous genetic mix, significant heritability for adiponectin and obesity traits substantiate a genetic contribution to circulating cytokine levels in Hispanic children (7,8). Furthermore, the age profile of the population is an important factor related to the pathophysiology of MetS and adiponectin concentration (9).…”

<strong><b>A</b></strong><strong><b>ssociations between Bioactive Algal Biomaterial Supplementation, Dietary Pattern and </b></strong><strong><b>M</b></strong><strong><b>etabolic Risk Markers in Japanese Women</b></strong>

“…In addition to well-known cardiometabolic health markers, namely systolic blood pressure (SBP), diastolic blood pressure (DBP), circulating cholesterol level, fasting blood glucose (FBG), body weight, waist circumference (WC), etc. [6], recent investigations have demonstrated that circulatory c-reactive protein (CRP) [7][8][9] and adiponectin [10][11][12][13] are strong predictors of most prevalent cardiometabolic diseases such as metabolic syndrome (MetS), diabetes, hypertension, coronary heart disease and atherosclerosis, and play a crucial role in their development. CRP has been suggested as an independent marker of cardiovascular diseases and a number of metabolic disorders, diabetes mellitus in particular [14,15].…”