Adiponectin, leptin and lipid profiles evaluation in oral contraceptive pill consumers

Abstract

LD COC uptake results in a significant decrease in serum adiponectin concentration, nonsignificant increase in leptin levels and a more atherogenic lipid profile by significantly increasing LDL and nonsignificantly decreasing HDL concentrations. These findings suggested that COC may reduce or stimulate the adiponectin and leptin concentrations, respectively. This might be due to an effect of these pills on adipocyte maturation via inhibition or stimulation of the synthesis of new adiponectin and leptin molecules or may be a result of the increased frequency of a particular allele of the adiponectin and leptin. It is suggested that these alterations in adiponectin and leptin concentrations and lipid profiles may be related to their probable effects in response to various pathological and physiological properties of COC or its metabolites. It seems that probably free radicals produced during metabolism of COCs change the amounts of adipokines and atherogenic lipids.

The Use of Hormonal Contraceptives and Preeclampsia among Ghanaian Pregnant Women

“…The preeclamptic women demonstrated significant dyslipidemia in comparison with the normal pregnant women. Although studies that assessed lipid profile in pregnant women who used progestin-only contraceptive prior to pregnancy remain scarce, data on women who used Combined Oral Contraceptive (COC) indicated that COC uptake results in a more atherogenic lipid profile by increasing LDL-C and decreasing HDL-C concentrations [23]. It has also been suggested that perhaps free radicals produced during metabolism of hormonal contraceptives change the amounts of atherogenic lipids [24].…”

Sex Differences in Mechanisms of Hypertension Associated With Obesity

“…Rises in leptin do not necessarily follow the phases of the menstrual cycle in which estrogen levels are highest 86 . In addition, the literature is not consistent in demonstrating that leptin levels increase in women taking oral contraceptives 88, 89 . These data indicate that the ability of estrogen to stimulate leptin, or vice versa, is likely a complex relationship, and further investigation is warranted.…”

Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers

“…Participants were excluded because of missing data and use of hormone medications, including systemic corticosteroids (n=2), steroid hormones (n=26), steroid hormones and corticosteroids (n=1), or thyroid hormones (n=41). We excluded participants taking hormone medications (sex steroids, corticosteroid or thyroid) because of potential effects on diabetes biomarkers and HA1c (Brand et al 2011;Fallah et al 2012;Sargeant et al 2000). The final sample size for analysis was 413.…”