Adiponectin/Leptin Ratio as an Index to Determine Metabolic Risk in Patients after Kidney Transplantation

Graňák, Karol; Vnučák, Matej; Beliančinová, Monika; Kleinová, Patrícia; Pytliaková, Margaréta; Miklušica, Juraj; Dedinská, Ivana

doi:10.3390/medicina58111656

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Monitoring of adipose tissue hormones in the transplant population has only a short history, and until now they have been investigated as separate variables in correlation with cardiometabolic risk factors. In our recently published work, we found that a high-risk A/L ratio (<0.5) was significantly associated with the occurrence of post-transplant diabetes mellitus (PTDM) and pre-diabetic conditions 1 year after KT (13).…”

Section: Discussionmentioning

confidence: 95%

Adiponectin/leptin ratio as a predictor of acute rejection in early post-transplant period in patients after kidney transplantation

Graňák

Vnučák²,

Beliančinová³

et al. 2023

Front. Med.

Self Cite

View full text Add to dashboard Cite

IntroductionAdipokines are largely involved in the regulation of immune system activity. While leptin is the main pro-inflammatory marker of adipose tissue, adiponectin is characterized by anti-inflammatory effects. The aim of our study was to determine the risk of acute graft rejection in protocol biopsy depending on the adiponectin/leptin (A/L) ratio in patients after kidney transplantation (KT).Materials and methodsA total of 104 patients were included in the prospective analysis, in whom the levels of adipokines were examined pre-transplant, in the 3rd month after KT and the A/L ratio was calculated. In the 3rd month after KT, all patients underwent protocol biopsy of the graft and examination of donor-specific antibodies (DSA) using the Luminex method.ResultsAfter adjusting for differences in the basic characteristics of the donor and recipient, we identified a subgroup with A/L ratio < 0.5 pre-transplant [HR 1.6126, (P = 0.0133)] and 3 months after KT [HR 1.3150, (P = 0.0172)] as independent risk factor for acute graft rejection. In the subsequent specification of the rejection episode, we identified the risk ratio A/L < 0.5 before KT [HR 2.2353, (P = 0.0357)] and 3 months after KT [HR 3.0954, (P = 0.0237)] as independent risk factor for the development of acute humoral rejection with DSA positivity.ConclusionThis is the first study to investigate the relationship between A/L ratio and immunological risk in terms of the development of rejection changes in patients after KT. In our study, we found that A/L ratio < 0.5 is an independent risk factor for the development of acute humoral rejection and de novo DSA production in the third month after KT.

show abstract

Section: Discussionmentioning

confidence: 95%

Adiponectin/leptin ratio as a predictor of acute rejection in early post-transplant period in patients after kidney transplantation

Graňák

Vnučák²,

Beliančinová³

et al. 2023

Front. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

Nutritional Status and Selected Adipokines in Children with Irritable Bowel Syndrome

et al. 2022

View full text Add to dashboard Cite

Background: The aim of this study was to assess the nutritional status and serum concentrations of adipokines in children with irritable bowel syndrome (IBS) and healthy controls. We also sought to evaluate their relation to metabolic parameters. Methods: We studied 33 IBS patients (11 girls, 22 boys) aged 5–17 years and 30 healthy age-matched controls (11 girls, 19 boys). The analysis included anthropometric measurements, body composition parameter measurements using bioimpedance, and biochemical tests and measurements of serum concentrations of leptin, adiponectin, chemerin, and omentin-1. Results: The results of the anthropometric measurements were comparable between the patients and the controls. The patients had higher triglycerides, HOMA-IRs, and chemerin concentrations than the healthy subjects. The HDL cholesterol and omentin-1 levels were lower than in the controls. Leptin and adiponectin did not differ significantly between the groups. An analysis of the receiver operator curves (ROCs) showed that serum concentrations of chemerin ≥ 232.8 ng/mL had 30% sensitivity and 87% specificity when they were used to differentiate between children with IBS and healthy subjects. In the case of serum omentin-1 concentrations ≤ 279.4 ng/mL, the sensitivity and specificity were 60% and 80%, respectively. Conclusions: The nutritional status of children with IBS did not differ from that of the healthy controls. We found significant differences in serum chemerin and omentin-1 concentrations between IBS patients and healthy children. These adipokines could be used as IBS biomarkers as they demonstrate good specificity and moderate sensitivity. The serum concentrations of chemerin and omentin-1 in IBS patients were related to nutritional status and insulin resistance.

show abstract

Adiponectin/Leptin Ratio as an Index to Determine Metabolic Risk in Patients after Kidney Transplantation

Cited by 2 publications

References 22 publications

Adiponectin/leptin ratio as a predictor of acute rejection in early post-transplant period in patients after kidney transplantation

Adiponectin/leptin ratio as a predictor of acute rejection in early post-transplant period in patients after kidney transplantation

Nutritional Status and Selected Adipokines in Children with Irritable Bowel Syndrome

Contact Info

Product

Resources

About