Adiponectin level changes among Egyptians with gastroesophageal reflux disease

Abstract

Background and AimVisceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.MethodsIn this study, 150 subjects were selected and divided into four groups: Group І (n = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ (n = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ (n = 40) were patients with severe erosive esophagitis; and finally, Group ІV (n = 20) were patients with Barrett's esophagus. Upper gastrointestinal endoscopy was performed for Groups II, III, and IV only, and histopathological assessment was conducted for the suspicious cases of Barrett's esophagus. The measurement of serum adiponectin was performed for all groups using the ELISA test.ResultsOur results revealed that the serum level of adiponectin was significantly lower in patients with different grades of GERD as well Barrett's esophagus as compared to healthy controls (P‐value < 0.001). Additionally, the serum level of adiponectin was correlated with different grades of GERD as the highest level of the adiponectin was found in the control group (11.05 ± 2.58) followed by mild to moderate GERD (6.39 ± 1.64) and then severe GERD (2.42 ± 1.00); finally, the lowest level was detected in the Barrett's esophagus group (1.99 ± 0.47). Our study showed significant correlation between body mass index, waist circumference, and waist–hip ratio on one hand and serum adiponectin level on the other hand, with a statistically significant difference (P‐value < 0.001). The best cut‐off value for serum adiponectin was 7.7 (μg/mL), with a sensitivity of 91.8% and specificity of 97.5%.ConclusionsLow serum adiponectin level appears to be associated with an increased risk of erosive esophagitis, and visceral fat accumulation is related to the impaired secretion of adiponectin, which may have an influence on the pathogenesis of GERD.

Hubungan Obesitas Terhadap Kejadian Gastroesophageal Reflux Disease Pada Mahasiswa Fakultas Kedokteran Universitas Baiturrahmah

“…10 Selain itu, jaringan lemak viseral secara metabolik berkaitan dengan penurunan kadar sitokin anti-inflamasi dalam serum seperti adiponektin, dan peningkatan kadar sitokin pro-inflamasi seperti interleukin-6 dan tumor necrosis factor-α (TNF-α )yang dapat berfungsi pada pembentukan erosive esophagitis. 11 Perubahan perilaku dan gaya hidup mahasiswa, seperti kebiasaan makan yang tidak seimbang, dapat dipengaruhi oleh kemajuan teknologi, industri, dan sosial ekonomi yang terus maju. Salah satu faktor yang dapat mempengaruhi terjadinya GERD adalah pola makan.…”

Hubungan Obesitas dengan Kejadian Gastroesophageal Reflux Disease di RSUP Dr. M. Djamil Padang

“…9 Penderita obesitas yang memiliki lingkar perut melebihi batas normal dapat meningkatkan risiko untuk terkena GERD. 11 Penumpukan lemak di abdomen dapat menurunkan fungsi motorik esofagus & Lower Esophageal Sphincter (LES), meningkatkan tekanan intragastric & kapasitas lambung, dan meningkatkan kecenderungan terbentuknya hiatal hernia sehingga refluksat lambung menjadi lebih mudah naik ke esofagus dan menimbulkan peristiwa GERD. 10 Selain itu, jaringan lemak viseral secara metabolik berkaitan dengan penurunan kadar sitokin antiinflamasi dalam serum seperti adiponektin dan peningkatan kadar sitokin pro-inflamasi seperti interleukin-6 dan tumor necrosis factor-a (TNFa) yang dapat berperan dalam pembentukan erosive esophagitis.…”

“…10 Selain itu, jaringan lemak viseral secara metabolik berkaitan dengan penurunan kadar sitokin antiinflamasi dalam serum seperti adiponektin dan peningkatan kadar sitokin pro-inflamasi seperti interleukin-6 dan tumor necrosis factor-a (TNFa) yang dapat berperan dalam pembentukan erosive esophagitis. 11 Sebuah penelitian yang dilakukan di Amerika Serikat menunjukkan bahwa pasien yang menderita obesitas memiliki risiko 2,5 kali lebih besar daripada yang memiliki indeks massa tubuh normal untuk terjadi gejala refluks atau erosive esophagitis. 10 Pada penelitian ini terdapat 453 pasien dan 118 pasien di antaranya memiliki gejala refluks serta 44 pasien yang ditemukan erosive esophagitis.…”