Adiponectin Levels and Coronary Artery Disease among HIV-Infected Men

Norton, Louise

doi:10.4172/2155-6113.1000208

Cited by 1 publication

(1 citation statement)

References 64 publications

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“…[31] Our study differs from this study in that we included an HIV-uninfected group, evaluated a larger number of patients, and evaluated coronary plaque using Coronary CT angiography in addition to non-contrast CT.…”

Section: Discussionmentioning

confidence: 99%

Lower adiponectin is associated with subclinical cardiovascular disease among HIV-infected men

Ketlogetswe

Post

et al. 2014

Aids

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Objective To examine if altered levels of adipokines, adipose-derived peptides associated with myocardial infarction in the general population, may contribute to subclinical coronary atherosclerosis in HIV-infected persons. Design Nested cohort study. Methods We studied HIV-infected(HIV+) and HIV-uninfected(HIV−) men in the Multicenter AIDS Cohort Study with noncontrast CT to measure coronary artery calcium and regional adiposity; 75% additionally underwent coronary CT angiography to measure plaque composition and stenosis. Adiponectin and leptin levels were assessed. Multiple regression models were used to assess associations between adipokine levels and HIV disease parameters, regional adiposity, and plaque adjusted for age, race, HIV serostatus and CVD risk factors (RFs). Results Significant findings were limited to adiponectin. HIV+ men (n=493) had lower adiponectin levels than HIV− men (n=250) after adjusting for CVD RFs (p<0.0001), which became non-significant after adjustment for abdominal visceral and thigh subcutaneous adipose tissue. Among HIV+ men, lower adiponectin levels were associated with higher CD4+ T cell counts (p= 0.004), longer duration of antiretroviral therapy (p= 0.006) and undetectable HIV RNA levels (p = 0.04) after adjusting for age, race and CVD RFs; only CD4+ cell count remained significant after further adjustment for adipose tissue. In both groups, lower adiponectin levels were associated with increased odds of coronary stenosis > 50% (p <0.007). Lower adiponectin levels were associated with increased extent of plaque in HIV+ and of mixed plaque in HIV− men. Conclusions Adiponectin levels were lower in HIV-infected men and related to the severity of subclinical atherosclerosis, independent of traditional CVD risk factors.

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Section: Discussionmentioning

confidence: 99%