Adiponectin levels in Brazilian adolescents: Distribution and associated factors in ERICA survey

Sparrenberger, Karen; Teló, Gabriela Heiden; Schaan, Beatriz D.

doi:10.1016/j.cca.2018.01.017

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…In a previous publication, we described the adiponectin distribution and showed that lower levels of this adipokine were associated with general and abdominal obesity among Brazilian adolescents [10]. In metabolically unhealthy subjects, especially in the presence of obesity, circulating adiponectin is also reduced [11–13].…”

Section: Introductionmentioning

confidence: 99%

Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Sparrenberger

Sbaraini

Teló

et al. 2019

Diabetol Metab Syndr

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Objective To evaluate the association between adiponectin concentrations and metabolic syndrome (MetS) risk and to investigate if this association is independent of weight status in adolescents. Methods Adiponectin concentrations and MetS risk were assessed in 4546 Brazilian adolescents (12–17 years old) enrolled in The Study of Cardiovascular Risks in Adolescents (“ERICA”), a cross-sectional multicenter study in Brazil. For analyses, adiponectin was categorized in sex and age-specific quartiles and MetS risk was expressed as a continuous score, calculated as the average of the standardized values (z-score) of the five MetS components. Multiple linear regression models were used to investigate the association between the quartiles of adiponectin and MetS risk. Results Adiponectin was inversely associated with waist circumference and log-transformed triglycerides, and positively associated with HDL-c. We also observed an inverse association between adiponectin concentrations and MetS risk. After adjustment for sociodemographic variables, physical activity, skipping breakfast and body mass index (BMI), higher quartiles of adiponectin remained inversely associated with waist circumference and MetS risk. A direct association between adiponectin and HDL-c was also observed. In further analysis, the sample was stratified by weight status and an inverse association between quartiles of adiponectin and MetS risk was observed in both normal weight and overweight/obese adolescents. Conclusion Higher adiponectin concentrations were independently and inverse associated with MetS risk in Brazilian adolescents, even after adjusting for BMI. These results were similar in normal weight and overweight/obese adolescents, suggesting that adiponectin may play a role in early development of MetS. Electronic supplementary material The online version of this article (10.1186/s13098-019-0435-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Sparrenberger

Sbaraini

Teló

et al. 2019

Diabetol Metab Syndr

Self Cite

View full text Add to dashboard Cite

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“…Além disso há relatos na literatura apontando a diminuição da adiponectina em quadros de doenças como a obesidade (Sparrenberger et al 2018), doença comorbida com a DE. Ainda não havia estudos que avaliassem os níveis de adiponectina frente a disfunção erétil além disso o próprio mecanismo de variação dos níveis de adiponectina carece de explicação completa.…”

Section: Análises Estatísticasunclassified

“…Ainda não havia estudos que avaliassem os níveis de adiponectina frente a disfunção erétil além disso o próprio mecanismo de variação dos níveis de adiponectina carece de explicação completa. Em diferentes estudos, os níveis de adiponectina também variaram de acordo com idade, sexo e estágio puberal, além da alimentação (Artimani et al 2016, Sparrenberger et al 2018. Uma explicação plausível para o fato do aumento da adiponectina no grupo paciente está no chamado ''paradoxo'' da adiponectina (Teoh et al 2006).…”

Section: Análises Estatísticasunclassified

Análise dos polimorfismos rs266729 e rs1501299 e dos níveis de adiponectina em homens com disfunção erétil e sua associação com a reposta ao tratamento com sildenafil

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Longitudinal associations between vitamin D status and biomarkers of inflammation in a pan-European cohort of children and adolescents

Wolters,

Foraita,

Moreno

et al. 2024

Eur J Nutr

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Purpose To investigate longitudinal associations between the vitamin D status and inflammatory markers in children and adolescents. Methods Children from eight European countries from the IDEFICS/I.Family cohort with repeated measurements were included in this study. A linear mixed-effect model was used to model the association of serum 25(OH)D as independent variable and z-scores of inflammatory markers [CRP, cytokines, adipokines, combined inflammation score] as dependent variables, where one level accounts for differences between individuals and the other for changes over age within individuals. Results A total of 1,582 children were included in the study. In the adjusted model, 25(OH)D levels were positively associated with adiponectin (β = 0.11 [95% CI 0.07; 0.16]) and negatively with the inflammation score (β = − 0.24 [95% CI − 0.40; − 0.08]) indicating that the adiponectin z-score increased by 0.11 units and the inflammation score decreased by 0.24 units per 12.5 nmol/l increase in 25(OH)D. In children with overweight or obesity, only a positive association between 25(OH)D and IP-10 was observed while in children with normal weight adiponectin was positively and the inflammation score was negatively associated. Associations of vitamin D with adiponectin and the inflammation score were stronger in girls than in boys and a positive association with TNF-α was observed only in girls. Conclusion Our results suggest that an increase in vitamin D concentrations may help to regulate inflammatory biomarkers. However, it seems to be no benefit of a better vitamin D status in children with overweight/obesity unless their weight is managed to achieve an improved inflammatory marker status.

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Adiponectin levels in Brazilian adolescents: Distribution and associated factors in ERICA survey

Cited by 5 publications

References 34 publications

Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Análise dos polimorfismos rs266729 e rs1501299 e dos níveis de adiponectina em homens com disfunção erétil e sua associação com a reposta ao tratamento com sildenafil

Longitudinal associations between vitamin D status and biomarkers of inflammation in a pan-European cohort of children and adolescents

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