Adiponectin levels in maternal serum and umbilical cord blood at birth by mode of delivery: relationship to anthropometric measurements and fetal sex

Daryasari, Seyedeh Razieh Fazeli; Tehranian, Najmeh; Kazemnejad, Anoshirvan; Razavinia, Fatemeh; Tatari, Fatemeh Tork; Pahlavan, Fattaneh

doi:10.1186/s12884-019-2460-y

Cited by 10 publications

(11 citation statements)

References 34 publications

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“…On the other hand, an increase in adiponectin in both MP and UCP in Enterotype II group was observed. Daryasari et al observed differences on maternal plasma adiponectin levels depending on the mode of delivery [43]. They found that umbilical cord blood from vaginal delivery had higher levels of adiponectin.…”

Section: Discussionmentioning

confidence: 99%

Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles

Rio-Aigé

Azagra-Boronat

Massot-Cladera

et al. 2021

IJMS

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Mothers confer natural passive immunization to their infants through the transplacental pathway during the gestation period. The objective of the present study was to establish at birth the maternal and cord plasma concentration and relationship of immunoglobulins (Igs), cytokines (CKs), and adipokines. In addition, the impact of the maternal microbiota and diet was explored. The plasma profile of these components was different between mothers and babies, with the levels of many CKs, IgM, IgG2a, IgE, IgA, and leptin significantly higher in mothers than in the cord sample. Moreover, the total Igs, all IgG subtypes, IgE, and the Th1/Th2 ratio positively correlated in the mother–infant pair. Maternal dietary components such as monounsaturated fatty acids-polyunsaturated fatty acids and fiber were positively associated with some immune factors such as IgA in cord samples. The microbiota composition clustering also influenced the plasma profile of some factors (i.e., many CKs, some Ig, and adiponectin). In conclusion, we have established the concentration of these immunomodulatory factors in the maternal–neonatal pair at birth, some positive associations, and the influence of maternal diet and the microbiota composition, suggesting that the immune status during pregnancy, in terms of CKs and Igs levels, can influence the immune status of the infant at birth.

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Section: Discussionmentioning

confidence: 99%

Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles

Rio-Aigé

Azagra-Boronat

Massot-Cladera

et al. 2021

IJMS

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“…However, investigating leptin in first and second trimester blood samples of 582 pregnant women did not identify any sex dependent difference [ 30 ]. Angiopoietin levels seem not different between women carrying a boy vs. women carrying a girl [ 102 ].…”

Section: Placental Hormones: Role In Glucose Metabolism and Sex Dimorphismmentioning

confidence: 99%

Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex

Stern

Schwarz

Moser

et al. 2021

IJMS

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The placenta is an endocrine fetal organ, which secretes a plethora of steroid- and proteo-hormones, metabolic proteins, growth factors, and cytokines in order to adapt maternal physiology to pregnancy. Central to the growth of the fetus is the supply with nutrients, foremost with glucose. Therefore, during pregnancy, maternal insulin resistance arises, which elevates maternal blood glucose levels, and consequently ensures an adequate glucose supply for the developing fetus. At the same time, maternal β-cell mass and function increase to compensate for the higher insulin demand. These adaptations are also regulated by the endocrine function of the placenta. Excessive insulin resistance or the inability to increase insulin production accordingly disrupts physiological modulation of pregnancy mediated glucose metabolism and may cause maternal gestational diabetes (GDM). A growing body of evidence suggests that this adaptation of maternal glucose metabolism differs between pregnancies carrying a girl vs. pregnancies carrying a boy. Moreover, the risk of developing GDM differs depending on the sex of the fetus. Sex differences in placenta derived hormones and bioactive proteins, which adapt and modulate maternal glucose metabolism, are likely to contribute to this sexual dimorphism. This review provides an overview on the adaptation and maladaptation of maternal glucose metabolism by placenta-derived factors, and highlights sex differences in this regulatory network.

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“…The exact mechanism of how maternal adiponectin levels can affect birthweight still deserves more investigation. While there are studies that did not find this association, 25,35 other authors observed a negative association. 36 However, our result corroborates with another recent study that showed a positive association between maternal adiponectin and birthweight.…”

Section: Discussionmentioning

confidence: 90%

“…21,22 Since adiponectin has an essential role in insulin metabolism and that glucose and insulin are crucial for fetal growth, maternal adiponectin may play an important role in fetal development; however, the literature results about this association are still controversial. [23][24][25] The aim of the present study was to evaluate serum adiponectin concentration in pregnant adolescents between 30 and 36 weeks of gestation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

Padua

Daher

Sampaio

et al. 2021

Rev Bras Ginecol Obstet

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Objective To evaluate serum levels of adiponectin in pregnant adolescents between 30 and 36 weeks of gestation. Method: A prospective cross-sectional study enrolled 67 normal pregnant women between 30 and 36 weeks of gestation and eutrophic (body mass index [BMI]: 18.5–25 kg/m2), of which 36 were adolescents (< 20 years old) and 31 adults (≥ 20 years old). Serum adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The t-student or Mann-Whitney tests were used for intergroup comparison. Results Pregnant adolescents showed significantly higher serum adiponectin concentrations compared with pregnant adults (p = 0.04). No differences were observed in adiponectin levels in younger pregnant adolescents (< 16 years old) compared with older pregnant adolescents (≥ 16 years old). Adiponectin values were divided into 3 subgroups: < 3,000 ng/mL, between 3,000 and 5,000 ng/mL, and > 5,000 ng/mL. Birthweight was significantly higher in women > 5,000 ng/mL when compared with < 3,000 ng/mL in the adolescent group. No association between pregestational adiponectin levels and BMI, gestational weight gain, and gestational age was observed; however, there was a positive relation with birthweight (p = 0.0239). Conclusion Serum adiponectin values in pregnant adolescents between 30 and 36 weeks of gestation were higher compared with pregnant adults; however, no differences between younger and older pregnant adolescents were observed.

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Adiponectin levels in maternal serum and umbilical cord blood at birth by mode of delivery: relationship to anthropometric measurements and fetal sex

Cited by 10 publications

References 34 publications

Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles

Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles

Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex

Evaluation of the Blood Level of Adiponectin in Pregnant Adolescents

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