Adiponectin Levels in Non-obese First-degree Relatives of Type 2 Diabetes Patients and Non-diabetic Subjects: A 5-Year Follow-up Study

Abstract

This study was designed to investigate adiponectin levels and their relationship to various parameters at baseline and after 5 years in non-obese first-degree relatives of type 2 diabetes patients (FDR group) versus subjects without a family history of diabetes (normal group). Adiponectin levels at baseline were lower in the FDR group versus the normal group. After 5 years, adiponectin levels had fallen significantly in both the FDR (24.3% reduction) and the normal (35.7% reduction) groups. Adiponectin levels were negatively correlated with waist/hip ratio, fasting plasma glucose, carotid intima-media thickness (IMT) and insulin resistance in the FDR group. When adjusted for relevant risk factors, adiponectin was associated with age, high-density lipoprotein-cholesterol and IMT; these factors explained 45% of the variation in adiponectin in the FDR group. In the normal group, multiple regression analyses revealed that low-density lipoprotein-cholesterol and IMT explained 25% of the variability in the adiponectin concentration. In both groups, however, the correlation between adiponectin and IMT just failed to reach statistical significance in this population group. We conclude that adiponectin levels were reduced in non-obese first-degree relatives of patients with type 2 diabetes and normal individuals over a 5-year period. This study supports previous findings that hypoadiponectinaemia is a risk factor for atherosclerosis.

The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels

“…In a cross-sectional study among healthy Korean men and women, lower serum adiponectin levels were associated with a family history of diabetes independently of obesity and insulin resistance [39]. Recently, it has been shown that the FDR group had lower adiponectin levels versus the normal group at baseline, and these levels were reduced in both groups over a five year period [40].…”

Plasma adiponectin and carotid intima–media thickness in non-obese patients with type 2 diabetes

“…But Dullaart et al included obese and non-obese patients in the study group and it is not clear to what extent the relationship between plasma adiponectin and carotid IMT, in their study, could be explained by other risk factors associated with obesity and metabolic syndrome. Liu, Wang, Cha, Chen, and Ding (2010) found that adiponectin levels were negatively-correlated with carotid IMT in non-obese first-degree relatives of patients with type 2 diabetes, but they did not study the correlation in patients with type 2 diabetes.…”

Research advances in metabolism 2016

“…Carotid intima–media thickness (cIMT) is a robust independent predictor of macroangiopathy, especially of coronary events and stroke. Several studies have investigated the relation of cIMT and the circulating adiponectin levels, reporting however contradictory results [62,63]. Gasbarrino et al performed a meta-analysis of the studies which investigated the relationship between APN and cIMT.…”