Adiponectin levels predict prediabetes risk: the Pathobiology of Prediabetes in A Biracial Cohort (POP-ABC) study

Jiang, Yunna; Owei, Ibiye; Wan, Jim Y.; Ebenibo, Sotonte; Dagogo‐Jack, Samuel

doi:10.1136/bmjdrc-2016-000194

Cited by 63 publications

(46 citation statements)

References 50 publications

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“…This study demonstrated significant reduction in adiponectin level in pre-diabetic and diabetic participants when compared with control group. Similar observation was documented in the study of Shrestha S et al [11], Pauer J et al [13] and Jiang Y et al [14].…”

Section: Discussionsupporting

confidence: 89%

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

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Background: Subclinical inflammation characterized by elevated inflammatory markers is found in diabetic patients. Inflammation, an important cardiovascular risk factor, is elevated in diabetics with poor glycemic control than those with good control. Aim: To study the effect of glycemic status on inflammatory markers in pre-diabetes and diabetes. Methods: This study included 300 subjects divided into 3 groups; Control: 100, Pre-diabetes: 100 patients and Diabetes: 100 patients. Basic details of all the participants like age and gender were recorded and laboratory investigations like fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), IL-6, CRP, fibrinogen, uric acid and adiponectin were conducted. Results: Compared to controls, the levels FBS, HbA1c, IL-6, CRP, fibrinogen and uric acid were elevated and adiponectin was decreased in pre-diabetes and diabetes. The inflammatory parameters (IL-6, CRP, fibrinogen, uric acid and adiponectin) were significantly correlated with glycemic parameters (FBS, HbA1c) in diabetes, i.e. r=0.28, r=0.55, r=0.2, r=0.48 and r=-0.4 respectively in case of FBS and r=-0.39, r=0.48, r=0.21, r=0.33 and r=-0.53 respectively for HbA1c. Similarly, in pre-diabetes, FBS correlated significantly with adiponectin (r=-0.19), fibrinogen (r=0.29) and uric acid (r=0.18) while that with HbA1c was significant with adiponectin (r=-0.31), IL-6 (r=0.25), CRP (r=0.21) and fibrinogen (r=0.3). Conclusion:The strong correlations observed between glycemic control parameters and inflammation parameters in prediabetes and diabetes suggested the crucial involvement of inflammation in the diabetes development. So better control of glycemia can cause significant reduction in inflammation and arrest the health burden.

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Section: Discussionsupporting

confidence: 89%

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Shrestha

Sharma

Kumar

et al. 2019

IJMBS

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“…In the present study, the insulin-sensitive phenotype was associated with higher adiponectin levels compared with the insulin-resistant phenotype in obese and non-obese subjects. Previous reports have also associated higher adiponectin levels with MHO phenotype36 45 and decreased risk of incident pre-diabetes 46…”

Section: Discussionmentioning

confidence: 84%

Insulin-sensitive and insulin-resistant obese and non-obese phenotypes: role in prediction of incident pre-diabetes in a longitudinal biracial cohort

Owei

Umekwe

Provo

et al. 2017

BMJ Open Diab Res Care

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ObjectiveWe measured insulin sensitivity with euglycemic clamp (Si-clamp) in initially normoglycemic African Americans (AA) and European Americans (EA), to probe the existence of subphenotypes of obesity and leanness, and their impact on incident dysglycemia during longitudinal follow-up.Research design and methods320 healthy subjects (176 AA, 144 EA; mean age 44.2±10.6 years) underwent baseline assessments, including Si-clamp and homeostasis model of insulin resistance (HOMA-IR) and were stratified into: insulin-resistant obese (IRO) (body mass index (BMI) >30 kg/m2, Si-clamp <0.1, HOMA-IR >2.5); insulin-sensitive obesity (ISO) (BMI >30 kg/m2, Si-clamp >0.1, HOMA-IR <2.5); insulin-resistant non-obese (IRN) (BMI <28 kg/m2, Si-clamp <0.1, HOMA-IR >2.5); insulin-sensitive non-obese (ISN) (BMI <28 kg/m2, Si-clamp >0.1, HOMA-IR <2.5). Outcome measures were cardiometabolic risks and incident pre-diabetes/type 2 diabetes (T2D) during 5.5 years.ResultsCompared with IRO, subjects with ISO had lower abdominal fat, triglycerides and high-sensitivity C reactive protein and higher adiponectin (p=0.015 to <0.0001). IRN subjects had higher cardiometabolic risk markers than ISN (p=0.03 to <0.0001). During 5.5-year follow-up, incident pre-diabetes/T2D was lower in ISO (31.3% vs 48.7%) among obese subjects and higher in IRN (47.1% vs. 26.0%) among non-obese subjects (p=0.0024). Kaplan-Meier analysis showed significantly different pre-diabetes/T2D survival probabilities across insulin sensitivity/adiposity phenotypes (p=0.0001).ConclusionsInsulin sensitivity predicts ~40% decrease in the relative risk of incident pre-diabetes/T2D among obese persons, whereas insulin resistance predicts ~80% increased risk among non-obese persons. This is the first documentation of healthy and unhealthy phenotypes of obesity and leanness in a prospective biracial cohort, using rigorous measurement of insulin sensitivity.

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“…Studies have shown increased levels of leptin, visfatin, and resistin in individuals with T2DM (18). In contrast, adiponectin levels are reportedly lower in patients with DM and metabolic syndrome (19) and studies have shown that their levels may be markers of the risk of prediabetes (20).…”

Section: Introductionmentioning

confidence: 99%

Increased insulin sensitivity in individuals with neurofibromatosis type 1

Martins¹,

Jansen²,

Rodrigues³

et al. 2018

Archives of Endocrinology and Metabolism

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Objects To compare insulin resistance (IR) and metabolic aspects of patients with neurofibromatosis type 1 (NF1) and individuals without the disease. Subjects and methods Forty patients with NF1 were matched by sex, age, and body mass index (BMI) to 40 controls from the community. Blood samples were collected for biochemical assessment. Homeostasis model assessment adiponectin (HOMA-AD), Homeostasis model assessment insulin resistance (HOMA-IR), and adiponectin/leptin ratio (ALR) were used to identify IR. Results The median HOMA-IR values were similar between the groups. However, the HOMA-AD value was significantly lower and the ALR significantly higher in the NF1 group. Fasting blood glucose (FBG), leptin, and visfatin levels of patients with NF1 were significantly lower, although adiponectin levels were significantly higher than those in the controls. Fasting insulin and blood glucose levels 2 hours after administration of 75 g of dextrose, glycated hemoglobin, and resistin showed no significant differences between groups. The HOMA-AD correlated with BMI, FBG, blood glucose levels 2 hours after administration of 75 g of dextrose, fasting insulin, glycated hemoglobin, adiponectin, leptin, visfatin, ALR, and HOMA-IR. The ALR correlated with BMI leptin, visfatin, and adiponectin. Conclusions Lower levels of FBG, leptin, visfatin, and HOMA-AD, and higher adiponectin levels and ALR may be related to increased insulin sensitivity and lower occurrence of type 2 diabetes mellitus in patients with NF1.

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Adiponectin levels predict prediabetes risk: the Pathobiology of Prediabetes in A Biracial Cohort (POP-ABC) study

Cited by 63 publications

References 50 publications

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Glycemic Status and the Markers of Inflammation: A Comparative Study in Patients With Pre-Diabetes and Diabetes

Insulin-sensitive and insulin-resistant obese and non-obese phenotypes: role in prediction of incident pre-diabetes in a longitudinal biracial cohort

Increased insulin sensitivity in individuals with neurofibromatosis type 1

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