Adiponectin Predicts High-Density Lipoprotein Cholesterol Efflux Capacity in Adults Irrespective of Body Mass Index and Fat Distribution

Marsche, Gunther; Zelzer, Sieglinde; Meinitzer, Andreas; Kern, Sabine; Meissl, Sabine; Pregartner, Gudrun; Weghuber, Daniel; Almer, Gunter; Mangge, Harald

doi:10.1210/jc.2017-00933

Cited by 47 publications

(29 citation statements)

References 33 publications

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“…On the other hand, studies in cellular and animal models have shown that adiponectin can activate the peroxisome proliferator-activated receptor alpha (PPAR-alpha), leading to increase in apolipoprotein A-I hepatic production. In macrophages and hepatocytes, adiponectin activates the liver X nuclear receptor and stimulates expression of the ATP-binding cassette transporter (ABCA1) [29], which favor cholesterol efflux and HDL synthesis [30]. Collectively considered, these findings suggest that adiponectin increases the synthesis and decreases HDL clearance, which suppoarts the findings reported in epidemiological studies [6,7], as well as in the present study.…”

Section: Discussionsupporting

confidence: 88%

Inflammasome activation markers are independently associated with hypoalphalipoproteinemia in a Mexican-Mestizo population

Moeini¹,

Posadas‐Romero²,

Jorge‐Galarza³

et al. 2018

Clinical-Investigation

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Background: High-density lipoprotein cholesterol (HDL-C) concentrations are determined by environmental and metabolic factors, but systemic inflammation markers had been less studied. Aim:To evaluate the independent association of systemic inflammation markers to HDL-C concentration, considering the relative contribution of envioromental, and metabolic factors, in a well-characterized Mexican-Mestizo population. Methods:We used logistic regression and linear regression analysis to assess the effect of inflammatory (high sensitivity C-reactive protein (hs-CRP), adiponectin, tumor necrosis factor alpha, interleukins 6, 10, 15, and 1β), environmental (diet and physical activity) and metabolic factors (triglyceride (TG) levels, insulin resistance, abdominal visceral fat) on HDL-C concentrations, in 907 adults (46.5% female, aged 52 ± 9 years), without diabetes, TG ≤ 600 mg/dL, and hs-CRP ≤ 3 mg/L. Results:We found hypoalphalipoproteinemia (HA: HDL-C ≤ 50 mg/dL in women and ≤ 40 mg/ dL in men) in 44.8% of women and 48.8% of men. Carbohydrate intake (standardized coefficient β: -0.109 and -0.142), TG (-0.280 and -0.418), and interleukin-1β (-0.156 and -0.159) were inversely and independently associated to HDL-C levels, whereas adiponectin had a positive effect on the lipoprotein concentrations (0.196 and 0.169) for women and men, respectively (p<0.05 for all). Conjointly, these variables explained 33% of the variance in HDL-C levels. Conclusion:The study confirms the strong association of TG and carbohydrate intake with HDL-C levels. In addition, the results highlight the relevance of inflammatory processes in HA, which is one of the most prevalent cardiovascular risk factors in the Mexican population.

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Section: Discussionsupporting

confidence: 88%

Inflammasome activation markers are independently associated with hypoalphalipoproteinemia in a Mexican-Mestizo population

Moeini¹,

Posadas‐Romero²,

Jorge‐Galarza³

et al. 2018

Clinical-Investigation

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“…We quantified cholesterol efflux capacity with use of a previously published protocol ( 26 – 28 ). J774 cells, a mouse macrophage cell line, were plated and labeled for 24 h with 1 μCi/ml [ 3 H]cholesterol (Perkin Elmer, Boston, MA).…”

Section: Methodsmentioning

confidence: 99%

HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients [S]

Untersteller

Meissl

Trieb

et al. 2018

Journal of Lipid Research

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CVD remains the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD profoundly affects HDL composition and functionality, but whether abnormal HDL independently contributes to cardiovascular events in CKD patients remains elusive. In the present study, we assessed whether compositional and functional properties of HDL predict cardiovascular outcome among 526 nondialysis CKD patients who participate in the CARE FOR HOMe study. We measured HDL cholesterol, the content of HDL-associated proinflammatory serum amyloid A (SAA), and activities of the HDL enzymes paraoxonase and lipoprotein-associated phospholipase A2 (Lp-PLA2). In addition, we assessed the antioxidative activity of apoB-depleted serum. During a mean follow-up of 5.1 ± 2.1 years, 153 patients reached the predefined primary endpoint, a composite of atherosclerotic cardiovascular events including cardiovascular mortality and death of any cause. In univariate Cox regression analyses, lower HDL-cholesterol levels, higher HDL-associated SAA content, and lower paraoxonase activity predicted cardiovascular outcome, while Lp-PLA2 activity and antioxidative capacity did not. HDL-cholesterol and HDL-paraoxonase activity lost their association with cardiovascular outcome after adjustment for traditional cardiovascular and renal risk factors, while SAA lost its association after further adjustment for C-reactive protein. In conclusion, our data suggest that neither HDL quantity nor HDL composition or function independently predict cardiovascular outcome among nondialysis CKD patients.

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“…There, the ABCA1 protein and mRNA expression increased signi cantly in mice treated with adiponectin and the increase was found to be directly proportional to adiponectin concentration. Hence, this suggests that adiponectin plays a key role in the lipoprotein metabolism through the biosynthesis of HDL-c by modulation of the ABCA1 protein [53,54]. Furthermore, Tsubakio-Yamamoto and colleagues (2012) reported a positive correlation between adiponectin and HDL-c; whereas a negative correlation was observed between adiponectin and speci c cholesterol types, particularly the larger sized VLDL molecules and the smaller, dense LDL molecules.…”

Section: Discussionmentioning

confidence: 99%

Cross-Sectional Association of Adiponectin with Sociodemographic and Nutrition-Related Factors in Mexican Students from the Los Altos, Jalisco Region

González-Torres

González-Silva

Perez-Reyes

et al. 2020

Preprint

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Abstract Background Adiponectin is a biomarker useful for the early diagnosis of obesity-related comorbidities. The Mexican population has one of the highest obesity rates worldwide. The purpose of this study was to determine whether an association exists between adiponectin and certain sociodemographic and nutrition-related factors in young adults. This is perhaps one of only a few studies focused in the Los Altos, Jalisco area, a center for religious and cultural traditions in Mexico. Methods A cross-sectional analysis was conducted from January to November 2019 at the Los Altos University Center. A total of 173 student volunteers participating in the study provided voluntary signed, written consent forms. Sociodemographic data were collected. Biochemical and nutritional assessments were realized after eight hours of fasting. Dietary questionnaires were analyzed using Nutrikcal® software. Total serum adiponectin levels were quantified by enzyme-linked immunosorbent assay. Correlations and multivariate models were computerized by SPSSv20. This research project was approved and registered by the Research and Bioethics Committee of the Los Altos University Center, Mexico. Results According to body mass index (BMI), the incidence of underweight participants was found to be 10.4%, whereas that for overweight and obese patients combined was found to be 23.1%. A positive correlation of serum adiponectin levels was found in the following categories: female gender (r = 0.353, p = 0.01); high-density lipoprotein cholesterol (HDL-c) (r = 0.487, p = 0.01); and fruit intake (r = 0.204, p = 0.031). Multivariate analysis showed that 41.6% of adiponectin levels measured could be explained by gender, glucose, HDL-c, sodium and ascorbic acid consumption (r2 = 0.416, p < 0.01). Conclusions In accordance with the results, the incidence of underweight participants was greater than that expected as contrasted by national reports generated in Mexico. In addition, adiponectin level was found to vary with gender and nutrition-related factors. Further studies should be performed in this population to assess the role of religious and Mexican cultural traditions on health status in an effort to prevent undernutrition and obesity-related morbidity and mortality.

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Adiponectin Predicts High-Density Lipoprotein Cholesterol Efflux Capacity in Adults Irrespective of Body Mass Index and Fat Distribution

Abstract: Hypoadiponectemia is a robust predictor of reduced cholesterol efflux capacity in adults irrespective of BMI and fat distribution. Further investigations are needed to assess whether adiponectin is a causal determinant of CEC.

Cited by 47 publications

References 33 publications

Inflammasome activation markers are independently associated with hypoalphalipoproteinemia in a Mexican-Mestizo population

Inflammasome activation markers are independently associated with hypoalphalipoproteinemia in a Mexican-Mestizo population

HDL functionality and cardiovascular outcome among nondialysis chronic kidney disease patients [S]

Cross-Sectional Association of Adiponectin with Sociodemographic and Nutrition-Related Factors in Mexican Students from the Los Altos, Jalisco Region

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