2010
DOI: 10.1152/ajpheart.00115.2010
|View full text |Cite
|
Sign up to set email alerts
|

Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages

Abstract: primes human monocytes into alternative anti-inflammatory M2 macrophages. Am J Physiol Heart Circ Physiol 299: H656 -H663, 2010. First published July 9, 2010; doi:10.1152/ajpheart.00115.2010.-Altered macrophage kinetics is a pivotal mechanism of visceral obesityinduced inflammation and cardiometabolic risk. Because monocytes can differentiate into either proatherogenic M1 macrophages or antiinflammatory M2 macrophages, approaches that limit M1 while promoting M2 differentiation represent a unique therapeutic s… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

8
126
0
1

Year Published

2010
2010
2019
2019

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 203 publications
(135 citation statements)
references
References 40 publications
8
126
0
1
Order By: Relevance
“…Adiponectin can either act directly on macrophages to shift polarization (23) or indirectly by priming macrophages to IL-4-mediated M2 polarization (24). Here, we have interrogated the mechanisms for adiponectin-mediated polarization of macrophages, and we report that flAcrp is a very potent inducer of M2 macrophage polarization, both in RAW264.7 macrophages and in primary cultures of rat Kupffer cells.…”
mentioning
confidence: 82%
“…Adiponectin can either act directly on macrophages to shift polarization (23) or indirectly by priming macrophages to IL-4-mediated M2 polarization (24). Here, we have interrogated the mechanisms for adiponectin-mediated polarization of macrophages, and we report that flAcrp is a very potent inducer of M2 macrophage polarization, both in RAW264.7 macrophages and in primary cultures of rat Kupffer cells.…”
mentioning
confidence: 82%
“…Interestingly, recent reports regarding adiponectin have been focusing on a new feature of adiponectin, an aspect as a regulator of immune responses 22,23 . A number of experimental studies suggest that adiponectin attenuates excessive inflammatory responses in a variety of tissues, especially in obesity-associated states [24][25][26] . Roles of adiponectin in the development of psoriasis, one of the obesitylinked diseases as mentioned above, have been also discussed in the vast past epidemiologic reports [27][28][29] .…”
mentioning
confidence: 99%
“…However, under basal conditions, overproduction of p16 INK4A also exerted effects on the NFκB pathway, as shown by lower IκBα protein levels. IκBα is known to be anti-inflammatory [17] and inhibition of IκBα phosphorylation and subsequent degradation by adiponectin promotes M2 polarisation [29], suggesting that the anti-inflammatory effects of IκBα can enhance alternative polarisation. The lower IκBα levels in basal conditions after p16…”
mentioning
confidence: 99%