Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance

Nigro, Ersilia; Scudiero, Olga; Monaco, Maria Ludovica; Polito, Rita; Schettino, Pietro; Grandone, Anna; Perrone, Laura; Giudice, Emanuele Miraglia del; Daniele, Aurora

doi:10.1016/j.cyto.2016.12.018

Cited by 44 publications

(44 citation statements)

References 33 publications

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“…When comparing our cohort, stratified by the presence or absence of MetS, there is a suggestion that the prevalence of MetS increases directly with BMI. Similar to Turkish and Portuguese children with MetS and obese Italian children, in our study, no differences were observed in TChol level, suggesting that this indicator is less critical in this age group (24,31,32). However, in Korean children, an association between non-HDL cholesterol and MetS has been reported (33).…”

Section: Discussionsupporting

confidence: 80%

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Gomez¹,

Moreno-Mascareño²,

Angulo-Rojo³

et al. 2020

Jcrpe

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Childhood obesity linked to metabolic alterations, tend to appear simultaneously with altered adipocytokines, suggesting a role in pathogenetic development. Low circulating level of total and high molecular weight (HMW) adiponectin have been associated with components of the metabolic syndrome (MetS) and could represent an independent risk factor with potential use as a biomarker. To examine the prevalence of MetS in Mexican school children and to investigate the association of total and HMW adiponectin levels with biochemical parameters related to MetS. Methods: The study included a population of boys and girls, from 8 to 11 years old. Anthropometric and biochemical parameters were evaluated according to weight and MetS status. A correlation analysis was fitted to establish an association between adiponectin concentrations and metabolic indicators. Results: One-hundred and fifty five children participated (59.4% females) from 8-11 years of age. The prevalence of MetS was of 10.3%. Impaired biochemical parameters, including total and HMW adiponectin, were associated with obesity. The adiponectin level was significantly lower in MetS than in non-MetS subjects (4.5 vs. 5.4 μg/mL). Total-but not HMW adiponectin concentration was negatively correlated with blood pressure, fasting insulin, fasting blood sugar and Homeostatic Model Assessment for Insulin Resistance. Conclusion: In young children, the total adiponectin level is associated with impaired biochemical parameters of carbohydrate metabolism and could be an excellent early predictor of metabolic complications.

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Section: Discussionsupporting

confidence: 80%

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Gomez¹,

Moreno-Mascareño²,

Angulo-Rojo³

et al. 2020

Jcrpe

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“…Obesity is an excessive accumulation of adipose tissue and is associated with a variety of metabolic complications, including hypertension, dyslipidemia, cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) [1]. Evidence indicates that obesity is associated with low-grade inflammation and insulin resist-ance (IR) [2], which are characterized by increased circulatory levels of pro-inflammatory cytokines such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) as well as adipokines such as leptin, and decreased circulatory levels of adiponectin [3,4].…”

Section: Introductionmentioning

confidence: 99%

Circulating CTRP6 Levels are Increased in Overweight or Obese Chinese Individuals and Associated with Insulin Resistance Parameters: A Pilot Study

Liao

Tang

et al. 2019

Exp Clin Endocrinol Diabetes

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Aims CTRP6, a newly discovered adipokine, has been found to be a regulator for energy homeostasis. However, the association between circulating CTRP6 and obesity in humans is still unclear. Methods 256 individuals, including 185 overweight/obese (OW/OB) and 71 normal weight adults, were recruited for this study. Circulating concentrations of CTRP6 and adiponectin (Adipoq) were examined by ELISA. Results Serum CTRP6 levels in obese individuals were significantly increased compared with those in healthy individuals (506.1±134.9 vs.363.3±80.5 ng/mL, P<0.01). Conversely, serum Adipoq concentrations in OW/OB individuals were markedly decreased compared with healthy controls [20.8 (12.1–29.3) vs. 14.1 ( 8.61–17.7) ; P<0.01]. Correlation analysis revealed that there was a positive relationship between circulating CTRP6 and age, BMI, Fat%, LDL-C, TG, WHR, TC, FBG, FIns, HOMA-IR and HbA1c, but there was an inverse correlation with Adipoq and HDL-C. Logistic regression analysis revealed that high serum CTRP6 levels are markedly associated with OW/OB. Finally, ROC curve analysis showed that the cut-off value for serum CTRP6 for prediction of IR is 518 ng/mL. Conclusions CTRP6 may be a marker related to OW/OB.

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“…The study by Park et al indicated that irisin increased in individuals displaying metabolic syndrome and cardiovascular risk. Also, studies performed on children and adolescents [36,37] suggested a strong correlation of myokine with unhealthy metabolic parameters and obesity. Our study seems to suggest that irisin up-regulation is a mechanism occurring just at the beginning of a metabolic derangement, maybe as a compensatory mechanism to overcome a potential irisin resistance state.…”

Section: Discussionmentioning

confidence: 98%

“…Some previous studies have already explored the association of irisin with cardiometabolic variables in humans, but they differed from our study for the study population. In fact, they have been performed on children or adolescents [36,37] or adults with metabolic syndrome [38]. To our knowledge, the novelty of our study just deals in the evaluation of irisin and its association with sRAGE and its forms in apparently healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

Circulating Irisin and esRAGE as Early Biomarkers of Decline of Metabolic Health

Dozio

Vianello

Sitzia

et al. 2020

JCM

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A decline in metabolic health may take place before observing any alteration in the levels of the traditional metabolic markers. New indicators of metabolic derangement are therefore compelling. Irisin is a myokine with important metabolic functions. The role of irisin as a metabolic biomarker in humans has not been fully established yet. We quantified plasma irisin and esRAGE in 106 apparently healthy individuals and we performed a cluster analysis to evaluate their associations with metabolic profile. Plasma levels of various traditional markers of metabolic risk (i.e., glucose and lipid levels) were all within the ranges of normality. We identified two clusters of individuals. Compared to cluster 2, individuals in cluster 1 had higher irisin levels, a metabolic profile shifted toward the limits of the reference ranges and lower esRAGE levels. The traditional metabolic blood tests seem not to be enough to identify a metabolic decline early. Irisin increase and esRAGE decrease may reflect a metabolic derangement at the beginning of its development. The role of these molecules as early biomarkers of decline of metabolic health seems an interesting topic to be further explored.

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Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance

Cited by 44 publications

References 33 publications

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Association of Total and High Molecular Weight Adiponectin with Components of Metabolic Syndrome in Mexican Children

Circulating CTRP6 Levels are Increased in Overweight or Obese Chinese Individuals and Associated with Insulin Resistance Parameters: A Pilot Study

Circulating Irisin and esRAGE as Early Biomarkers of Decline of Metabolic Health

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