Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice

Masaki, Takayuki; Chiba, Seiichi; Tatsukawa, Hiroshi; Yasuda, Tohru; Noguchi, Hitoshi; Seike, Masataka; Yoshimatsu, Hironobu

doi:10.1002/hep.20282

Cited by 381 publications

(305 citation statements)

References 29 publications

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“…Adiponectin is reported to have an inverse association with hepatic inflammation in NASH patients [23]. On the contrary, recent data revealed a positive association in chronic hepatitis C patients, and inferred that the increased adiponectin in the scenario of hepatic inflammatory activity might be secondary to the response of viral infection [43].…”

Section: Discussionmentioning

confidence: 99%

“…It is positively correlated with insulin sensitivity and is decreased in obese and type 2 diabetic patients [22]. Adiponectin also antagonizes tumor necrosis factor-alpha (TNF-a) and modulates inflammatory responses [23]. In addition, adiponectin might have hepatic cytoprotective properties such as improving hepatic steatosis and injury in animal models of NAFLD [23].…”

Section: Introductionmentioning

confidence: 99%

“…Adiponectin also antagonizes tumor necrosis factor-alpha (TNF-a) and modulates inflammatory responses [23]. In addition, adiponectin might have hepatic cytoprotective properties such as improving hepatic steatosis and injury in animal models of NAFLD [23]. Our recent data further showed that adiponectin may correlate with hepatitis C viral factors at both serum and liver tissue levels [24,25].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic profiles in patients with chronic hepatitis C: a case–control study

Hsu

Liu

et al. 2008

Hepatol Int

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BackgroundThe clinical implications of metabolic profiles in patients with chronic hepatitis C remain controversial. To study the association of metabolic abnormalities with chronic hepatitis C, we conducted a case-control study with special emphasis on serum lipid pattern, fasting blood glucose, and adiponectin. Methods We enrolled 500 patients with chronic hepatitis C and 536 sex and age-matched controls. Unadjusted and adjusted associations of demographic and metabolic variables were estimated. Results Chronic hepatitis C patients had higher alanine aminotransferase (ALT) and high-density lipoprotein-cholesterol levels, but lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol levels than controls. Stratifying ALT level according to its upper limit of normal, HCV infection was associated with younger age, female gender, and higher TC levels in chronic hepatitis C patients with normal ALT levels, but with lower TC and lower TG levels in those with abnormal ALT levels. By using multiple linear regression analyses for subjects with available adiponectin data, presence of HCV infection was independently associated with higher serum adiponectin levels. Conclusions Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic profiles in patients with chronic hepatitis C: a case–control study

Hsu

Liu

et al. 2008

Hepatol Int

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“…ConA-induced hepatic inflammation is characterized by highly elevated systemic as well as hepatic TNF-a levels [11]. In addition, adiponectin has been shown to be a major antagonist of TNF-a production in several cell types [7,12]. Thus, its induction under conditions of acute inflammation within hepatic tissue might counteract the pro-inflammatory actions of TNF-a thereby forming a negative feedback loop attempting to counterbalance hepatic inflammation in vivo.…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice

Wolf¹,

Wolf²,

Avila³

et al. 2006

Journal of Hepatology

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“…In humans, circulating adiponectin levels are positively correlated with insulin sensitivity and decreased in obese and type 2 diabetic patients [5][6][7][8][9]. Adiponectin has also been found to antagonize tumor necrosis factor (TNF) a [10] and plays a central role in the attenuation of carbon tetrachlorideinduced liver fibrosis in mice [11]. Because adiponectin appears to induce insulin sensitivity and modulate inflammatory responses, its level in both healthy subjects and patients with different stages of liver diseases, particularly in those with nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C virus (HCV) infection, has been partly unraveled .…”

Section: Introductionmentioning

confidence: 99%

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

et al. 2008

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Purpose Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis B-related liver disease.Methods Serum adiponectin and hepatitis B viral factors were cross-sectionally assayed in 280 patients with chronic hepatitis B virus (HBV) infection including 120 patients with chronic HBV infection, 40 patients with cirrhosis, and 120 patients with hepatocellular carcinoma (HCC); 116 healthy adults were used as controls. The dynamics of serum adiponectin level was also studied longitudinally in 25 patients with hepatitis B e antigen (HBeAg) seroconversion (SC). Results We found that serum adiponectin level in patients with chronic HBV infection was similar to that in healthy controls and was significantly lower than patients with cirrhosis and HCC. In univariate analysis, high serum adiponectin level significantly correlated with the presence of HBV-related cirrhosis or HCC, abnormal serum ALT level, and HBV genotype C. Multivariate analysis revealed that high serum adiponectin level significantly correlated with the development of HCC. Serum adiponectin levels remained stationary in patients experiencing HBeAg SC. Conclusions Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC.

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Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice

Cited by 381 publications

References 29 publications

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Metabolic profiles in patients with chronic hepatitis C: a case–control study

Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

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