Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population

Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers

“…In agreement with our results, others could not attain a statistically signifi cant correlation between ELOVL4 gene and macular degeneration ( 28,42 ). The association of AdipoR1 gene expression with AMD risk in our cohort was insignifi cant ( P > 0.1), which is in contrast with a recently published Finnish population study ( 33 ). In fact, the risk allele of AdipoR1 (CT) was found in only 1 of our 15 AMD subjects.…”

“…Amplifi cation and genotype assignments were conducted using the 7900HT and SDS 2.4 software. The SNPs, rs381253 and rs10753929, used in this study were selected based on their association with ELOVL4 and adiponectin receptor 1 ( AdipoR1 ) as reported in earlier literature ( 32,33 ).…”

Review: adiponectin in retinopathy

“…In a Chinese population[86], APN genetic variant rs822396 is associated with advanced age-related macular degeneration. In addition, the AdipoR1 variant rs10753929 is a genetic risk factor for severe age-related macular degeneration in a Finnish population[6]. More advanced studies correlating APN levels with age-related macular degeneration status in patients will help us understand APN influences on age-related macular degeneration progression.…”

“…Accumulating evidence shows that APN, which is another important metabolic modulator also derived mainly from adipocytes, is associated with many retinal metabolic disorders. Circulating APN levels are correlated with the development and progression of retinopathy of prematurity [3], diabetic retinopathy [4, 5], and age-related macular degeneration[6]. Animal studies indicate that increasing circulating APN levels suppress pathological vascular proliferation in rodent models of oxygen-induced proliferative retinopathy and laser-induced choroidal neovascularization[7, 8].…”

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

“…In mice, FGF21 administration increases APN production to modulate glucose and lipid metabolism (Holland et al, 2013; Lin et al, 2013). Low circulating APN levels may contribute to the development of neovascular eye diseases in humans (Fu et al, 2016; Fu et al, 2015; Kaarniranta et al, 2012; Mao et al, 2012; Omae et al, 2015). APN administration inhibits retinal and choroidal neovascularization in rodents (Higuchi et al, 2009; Lyzogubov et al, 2012).…”