Adiponectin Signaling Regulates Lipid Production in Human Sebocytes

Abstract

Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that human sebaceous glands in vivo and sebocytes in vitro express adiponectin receptor and that adiponectin increased cell proliferation. Moreover, based on a lipogenesis study using Oil Red O, Nile red staining and thin layer chromatography, adiponectin strongly upregulated lipid production in sebocytes. In three-dimensional culture of sebocytes, lipid synthesis was markedly enhanced in sebocytes treated with adiponectin. This study suggested that adiponectin plays a significant role in human sebaceous gland biology. Adiponectin signaling is a promising target in the clinical management of barrier disorders in which sebum production is decreased, such as in atopic dermatitis and aged skin.

Metabolomic profiling implicates adiponectin as mediator of a favorable lipoprotein profile associated with NT-proBNP

“…However, in addition to adipocytes, various other cell types and tissues secrete adiponectin. Besides its main metabolic role in glucose homeostasis, adiponectin is also implicated in many other metabolic and inflammatory functions, including for instance tissue regeneration [ 32 ] and proliferation and function of sebocytes [ 33 ]. Considering a relation between BNP and adiponectin, it has to be noted that perivascular adipose tissue (PVAT) has significant influence on the vascular tone releasing anti-contractile factors, one of them being adiponectin.…”

Suppressed Adiponectin Levels and Increased Adiponectin Response to Oral Glucose Load in Lean Women with Severe Acne Normalizes after Isotretinoin Treatment

“…The study by Kovacs et al [24] supports our findings in part that adiponectin is associated with severe acne and isotretinoin is able to modulate adiponectin. Jung et al [25] specifically evaluated adiponectin signaling in sebaceous glands and demonstrated that human sebaceous glands in vivo and sebocytes in vitro expressed adiponectin receptors. They stated that adiponectin strongly upregulated lipid production in sebocytes.…”

The Trp64Arg polymorphism in β3 adrenergic receptor (ADRB3) gene is associated with adipokines and plasma lipids: a systematic review, meta-analysis, and meta-regression

“…Among these risk factors, the abnormal levels of adipokines [1,2] and lipids [3] are widely reported about their essential roles in the occurrence and progress of CAD. Both leptin and adiponectin are called adipokines, produced by white adipose tissue, one of the most potent lipid regulator [4][5][6], and plays a vital role in lipid metabolism [7][8][9]. Some new shreds of evidence have shown that leptin is positively related to dyslipidemia [10][11][12] in contrast to adiponectin, which is negatively related to dyslipidemia [13][14][15].…”

“…The ADRB3 gene is located on the long arm of human chromosome 8 (8p11. [1][2][3][4][5][6][7][8][9][10][11][12], and it contains two exons and one intron. The Trp64Arg polymorphism (also known as T190C, W64R, and rs4994) is the only function mutation of the ADRB3 gene, located in exon one and caused by substitution from thymine (T) to cytosine (C).…”