Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis

Liu, Chenxiao; Feng, Xiu; Li, Qi; Wang, Ying; Li, Qian; Hua, Majian

doi:10.1016/j.cyto.2016.06.028

Cited by 405 publications

(302 citation statements)

References 51 publications

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“…The levels of CRP were not different between the two groups (5). This finding contrasts with most studies associating low levels of adiponectin and increased levels of CRP with the risk of progression to T2D (6). Also published in this issue of "Archives of Endocrinology and Metabolism", Lobo Jr. and cols.…”

contrasting

confidence: 53%

Gestational diabetes mellitus and type 2 diabetes: same disease in a different moment of life? Maybe not

Zajdenverg

Negrato²

2017

Arch. Endocrinol. Metab.

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G estational diabetes mellitus (GDM) is a medical condition that has motivated many debates in the last decades regarding its etiology, pathophysiology, diagnosis, treatment and long-term consequences to the mother and to the fetus.Women who develop GDM present a metabolic condition similar to that found in type 2 diabetes (T2D) characterized by insulin resistance associated with inadequate insulin secretion (1). Due to similar pathophysiologic mechanisms found between T2D and GDM, there is a great interest in finding markers that will lead to the understanding of a possible common origin to both diseases. Women with GDM also present an inflammatory state that, together with insulin resistance can alter placental gene transcription and many features of fetal programming, that can lead to the development of several metabolic diseases later in life such as glucose intolerance, metabolic syndrome and also a high risk of presenting cardiovascular disease. Women with GDM have sevenfold higher risk of having T2D in the future (2).Identifying risk markers for the development of GDM or for poor perinatal outcomes will allow the implementation of precocious preventive or therapeutic interventions. Recently, several biomarkers have been evaluated in order to establish this possible relationship such as cord blood adiponectin, C-reactive protein (CRP), advanced glycation end products (AGEs) and a variety of genetic polymorphisms.Adiponectin exhibits an anti-inflammatory action and may potentially play a protective role in the development of GDM and T2D. Data regarding the relationship between cord blood levels of adiponectin, newborns birth weight and children adiposity are contradictory, with some studies finding a positive correlation (3) and others not showing any correlation (4).In the present issue of the "Archives of Endocrinology and Metabolism" in a study conducted by Aramesh and cols. in Iran, 52 women with GDM and 52 with normal glucose tolerance (NGT) were evaluated regarding fetal anthropometric parameters, cord blood adiponectin and CRP. It was found that adiponectin levels were higher in the presence of GDM and was also associated with higher birth weight and later gestational ages. The levels of CRP were not different between the two groups (5). This finding contrasts with most studies associating low levels of adiponectin and increased levels of CRP with the risk of progression to T2D (6). Also published in this issue of "Archives of Endocrinology and Metabolism", Lobo Jr. and cols. performed a study with 442 Euro-Brazilian women of which 225 had GDM and 217 presented NGT. Their study had the objective of evaluating the use of serum AGEs as a screening tool for GDM (7). It is well known that AGEs concentrations are associated with several diseases including type 1 and type 2 diabetes mainly in the presence of diabetes-related chronic complications (8). It is supposed that

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contrasting

confidence: 53%

Gestational diabetes mellitus and type 2 diabetes: same disease in a different moment of life? Maybe not

Zajdenverg

Negrato²

2017

Arch. Endocrinol. Metab.

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“…About half of the PCs identified in our study were directly associated with IS during the follow-up and inversely correlated with total saturated fat intake and circulating levels of hsCRP. Therefore, the protective effect of these metabolites on T2D might occur at least partly through its influence on IS29 and perhaps low-grade inflammation3031.…”

Section: Discussionmentioning

confidence: 99%

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

Mello

Paananen

Lindström

et al. 2017

Sci Rep

277

197

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Wide-scale profiling technologies including metabolomics broaden the possibility of novel discoveries related to the pathogenesis of type 2 diabetes (T2D). By applying non-targeted metabolomics approach, we investigated here whether serum metabolite profile predicts T2D in a well-characterized study population with impaired glucose tolerance by examining two groups of individuals who took part in the Finnish Diabetes Prevention Study (DPS); those who either early developed T2D (n = 96) or did not convert to T2D within the 15-year follow-up (n = 104). Several novel metabolites were associated with lower likelihood of developing T2D, including indole and lipid related metabolites. Higher indolepropionic acid was associated with reduced likelihood of T2D in the DPS. Interestingly, in those who remained free of T2D, indolepropionic acid and various lipid species were associated with better insulin secretion and sensitivity, respectively. Furthermore, these metabolites were negatively correlated with low-grade inflammation. We replicated the association between indolepropionic acid and T2D risk in one Finnish and one Swedish population. We suggest that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of T2D that may mediate its protective effect by preservation of β-cell function. Novel lipid metabolites associated with T2D may exert their effects partly through enhancing insulin sensitivity.

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“…IL-6 is a pro-inflammatory cytokine that contributes to the development of coronary artery disease and type 2 diabetes independently (Danesh et al, 2008; Liu et al, 2016). CRP is a marker of low-grade inflammation and shown to play a role in the pathogenesis of atherosclerotic lesions in humans (Blake & Ridker, 2002).…”

Section: Methodsmentioning

confidence: 99%

Association Between Immigration History and Inflammatory Marker Profiles Among Older Adult Mexican Americans

Martin

Haan

Fernández-Rhodes

et al. 2018

Biodemography and Social Biology

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Foreign-born Hispanics have better cardiometabolic health upon arrival in the US than their US-born counterparts, yet this advantage diminishes as duration of residence in the US increases. Underlying mechanisms explaining this paradox have been understudied. Using data from the Sacramento Area Latino Study on Aging (SALSA), this study examined immigration history (immigrant generation and duration of US residence) in relation to biomarkers of inflammation (interleukin-6 (IL-6), soluble forms of type 1 and 2 receptors of tumor necrosis factor-alpha (sTNF-R1 and sTNF-R2), C-reactive protein (CRP), leptin, adiponectin) in a sample of 1,290 predominantly Mexican-origin immigrants. Second and ≥3rd generation immigrants had higher IL-6 and leptin levels than 1st generation immigrants living in the US for less than 15 years (2nd generation percent difference = 45.9; 95% CI: 24.7, 70.7 and 3rd generation percent difference = 41.8; 95% CI: 17.7, 70.4). CRP and sTNF-R1 levels were higher among ≥3rd generation immigrants than 1st generation immigrants with less than 15 years of US residency. Worse inflammatory profiles were observed among Mexican-origin immigrants with longer US immigration histories, independent of health and behavioral factors. Additional research is warranted to understand the factors that shape trajectories of biological risk across generations of Hispanics.

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Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis

Cited by 405 publications

References 51 publications

Gestational diabetes mellitus and type 2 diabetes: same disease in a different moment of life? Maybe not

Gestational diabetes mellitus and type 2 diabetes: same disease in a different moment of life? Maybe not

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

Association Between Immigration History and Inflammatory Marker Profiles Among Older Adult Mexican Americans

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