Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging

Park, Byung Soon; Jang, Kyoung Ae; Sung, Jong Hwan; Park, Jeong‐Soo; Kwon, Yong Hyun; Kim, Kea Jeong; Kim, Won Serk

doi:10.1111/j.1524-4725.2008.34283.x

Cited by 137 publications

(107 citation statements)

References 6 publications

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“…Another is a paracrine effect on surviving, resident cells induced by the secretion of cytokines, growth factors, and other cellular factors. Evidence has also indicated that the regenerative effects are mediated by angiogenic, antiapoptotic, and growth factors secreted by ASCs [68,69,[127][128][129][130]. ASCs migrated into an injured or diseased organ or tissue may secrete these factors that stimulate recovery in a paracrine manner.…”

Section: Clinical Trialsmentioning

confidence: 96%

Adipose-Derived Stem Cells and Their Potential to Differentiate into the Epithelial Lineage

Baer

2011

Stem Cells and Development

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Adipose-derived stem cells (ASCs) possess a multilineage differentiation potential, can be used from an autologous origin, and are, therefore, attractive candidates for clinical applications to repair or regenerate damaged tissues and organs. Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared with other sources. It is easily accessible in large quantities with a minimal invasive harvesting procedure, and the isolation of ASCs yields a high amount of stem cells, which is essential for stem cell-based therapies and tissue engineering. Differentiation of ASCs into cell types of mesodermal origin has been shown in a variety of studies. The plasticity of ASCs toward cells of the mesodermal lineage has been shown by their differentiation into chondrocytes, osteoblasts, adipocytes, and myocytes. Their potential to differentiate into lineages with nonmesodermal origin is even more exciting: ASCs are also able to differentiate into cells of ecto- and endodermal origin. Various in vitro and in vivo studies documented the induced differentiation into neural cells, hepatocytes, pancreatic islet cells, endothelial cells, and epithelial cells. Epithelial cells can embryologically arise from each of the 3 germ layers. This article summarizes and discusses the current knowledge of the potential of ASCs to differentiate into the epithelial lineage. The differentiation of ASCs into different types of epithelial cells, including hepatocytes, pancreatic cells, and endothelial cells, is highlighted together with a view on current clinical trials and future options.

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Section: Clinical Trialsmentioning

confidence: 96%

Adipose-Derived Stem Cells and Their Potential to Differentiate into the Epithelial Lineage

Baer

2011

Stem Cells and Development

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“…27 Recently, the production and secretion of growth factors has been identified as essential functions of adipose stem cells, and diverse rejuvenation effects of adipose stem cells on skin have been demonstrated. 28,29 For example, they demonstrated that the cultured medium from adipose stem cells stimulated both collagen synthesis and migration of dermal fibroblasts during the wound-healing process. 30 The cultured medium of adipose stem cells also inhibited melanogenesis by down-regulation of tyrosinase and tyrosinase-related protein-1 (TRP-1) expression in the B16 melanoma cells.…”

Section: Discussionmentioning

confidence: 98%

Effect of cultured medium of human umbilical cord blood-derived mesenchymal stem cells on melanogenic enzyme activity in mouse B16 melanoma cells

Hwang

Son

Park

et al. 2014

Tissue Eng Regen Med

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The cultured medium of mesenchymal stem cell is a valuable resource for a variety of stem cell-derived cytokines and growth factors with a potential therapeutic effect on skin diseases. Here, we investigated the effect of the cultured medium of human umbilical cord blood-derived mesenchymal stem cell (CM-hCBSC) on melanogenesis in mouse B16 melanoma cells stimulated by α-melanocyte stimulating hormone (α-MSH). Our results show that CM-hCBSC inhibits melanin synthesis due to the decrease in cellular tyrosinase activity in B16 melanoma cells without cytotoxicity. The activity of melanogenic enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 were evaluated by western blot and semi-quantitative RT-PCR. The CM-hCBSC down-regulated the protein and mRNA expression levels of tyrosinase and TRP-1 in a dose-dependent manner. In addition, TRP-2 protein and mRNA expression levels were found to be down-regulated to a lesser extent. We also measured the level of cytokines in CM-hCBSC using the Luminex total system. It was found that the top enriched cytokine in the CMhCBSC was interukine-6 (IL-6), known as a potent regulator of melanin synthesis together with IL-1α and tumor necrosis factor α (TNF-α). These results indicate that secretary factors including IL-6 in the CM-hCBSC may inhibit melanin synthesis by down-regulating the expression of tyrosinase and TRP1. This study suggests that CMhCBSC has a therapeutic effect as an anti-melanogenic agent and may be effective against hyperpigmentation disorders.

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“…40 These effects have been evaluated in a porcine model, demonstrated by measuring growth factor production and collagen synthesis after injection of ADRCs. 40 Potentially, ADRCs may exert beneficial effects on angiogenesis and collagen production and potentially reduce aging and accumulation of abnormal elastin. In addition, mesotherapeutic applications of ADRCs have been anecdotally shown to improve hair growth in women with androgenetic alopecia (Fig.…”

Section: Mesotherapeutic Applicationsmentioning

confidence: 99%

Adipocyte-Derived Stem and Regenerative Cells in Facial Rejuvenation

Cohen¹,

Mailey²

2012

Clinics in Plastic Surgery

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Adipose-Derived Stem Cells and Their Secretory Factors as a Promising Therapy for Skin Aging

Abstract: ADSCs and their secretory factors show promise for application in cosmetic dermatology, especially in the treatment of skin aging.

Cited by 137 publications

References 6 publications

Adipose-Derived Stem Cells and Their Potential to Differentiate into the Epithelial Lineage

Adipose-Derived Stem Cells and Their Potential to Differentiate into the Epithelial Lineage

Effect of cultured medium of human umbilical cord blood-derived mesenchymal stem cells on melanogenic enzyme activity in mouse B16 melanoma cells

Adipocyte-Derived Stem and Regenerative Cells in Facial Rejuvenation

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