2019
DOI: 10.1155/2019/3673857
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Adipose-Derived Stem Cells in Bone Tissue Engineering: Useful Tools with New Applications

Abstract: Adipose stem cells (ASCs) are a crucial element in bone tissue engineering (BTE). They are easy to harvest and isolate, and they are available in significative quantities, thus offering a feasible and valid alternative to other sources of mesenchymal stem cells (MSCs), like bone marrow. Together with an advantageous proliferative and differentiative profile, they also offer a high paracrine activity through the secretion of several bioactive molecules (such as growth factors and miRNAs) via a sustained exosoma… Show more

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Cited by 85 publications
(79 citation statements)
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References 184 publications
(192 reference statements)
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“…Several materials with the ability to mimic the ECM have been investigated for scaffold production, potentiating the effects of ASCs. These materials range from decellularized tissue matrices to inorganic ceramics, such as bioceramics with application in hard tissue replacement orthodontic; polymers- natural proteins, polysaccharides with applications in connective and hard tissues, decellularized living tissues/organs and drug delivery; polymers synthetic degradable with application in implants and non-degradable for orthopedic implants; metals for orthopedic and dental application; composites with orthopedic and dental application [ 43 , 44 , 45 ].…”
Section: Biomaterialsmentioning
confidence: 99%
“…Several materials with the ability to mimic the ECM have been investigated for scaffold production, potentiating the effects of ASCs. These materials range from decellularized tissue matrices to inorganic ceramics, such as bioceramics with application in hard tissue replacement orthodontic; polymers- natural proteins, polysaccharides with applications in connective and hard tissues, decellularized living tissues/organs and drug delivery; polymers synthetic degradable with application in implants and non-degradable for orthopedic implants; metals for orthopedic and dental application; composites with orthopedic and dental application [ 43 , 44 , 45 ].…”
Section: Biomaterialsmentioning
confidence: 99%
“…Their main advantage is their potential for osteogenic differentiation in comparison to e.g., MG-63 cells which are arrested in pre-osteoblastic state (Czekanska et al, 2012 ). The potential of adipose-derived stem cells (ASC) for bone engineering has been recently highlighted (Vishnubalaji et al, 2012 ; Bhattacharya et al, 2016 ; Iaquinta et al, 2019 ; Storti et al, 2019 ) and ASC have been applied on biomaterial scaffolds as a potential critical size defect treatment strategy (Du et al, 2018 ). The high availability of ASC from body lipoaspirates (Yang et al, 2019 ) combined with the potential for osteogenic differentiation (Zhang et al, 2015 ) and defect reconstruction (Mesimäki et al, 2009 ; Yoshida et al, 2019 ; Zang et al, 2019 ) in vivo renders ASC excellent candidates to study the osteoinductive properties of biomaterials, with promising implications towards clinical translation (Barba et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…Using the patient's own stem cells to regenerate hair growth is a promising alternative therapeutic strategy [3]. Adipose-derived stem cells (ADSCs) are mesenchymal stem cells within the stromal vascular fraction (SVF) of subcutaneous adipose tissue, which have been extensively researched and have been applied in tissue engineering and regenerative medicine [4,5]. Furthermore, the field of ADSC-based regenerative medicine has now expanded to include the treatment of hair loss.…”
Section: Introductionmentioning
confidence: 99%