Adipose-derived stem cells promote peripheral nerve repair

Liu, Guibo; Cheng, Yi; Feng, Yukuan; ChaoJian, Pang; Li, Qi; Wang, Ying; Hua, Jia; Tong, Xin‐Kang

doi:10.5114/aoms.2011.24127

Cited by 87 publications

(87 citation statements)

References 21 publications

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“…36 More recently applied stem cells, such as hair follicle pluripotent stem cells and skin-derived stem cells, are also easily accessible and can transdifferentiate into Schwann cell-like cells as well. 23 Although most studies investigating the use of stem cell to enhance nerve regeneration have expressed enthusiasm and have promoted further research, 25,31 researchers have not compared their own data to other studies, nor has anyone proposed an evaluation protocol that would allow a correct comparison of the results. Therefore, the purpose of this meta-analysis is to summarize the effect of different types of stem cells in animal experimental studies used to enhance regeneration after reconstructing a peripheral nerve injury.…”

Section: ©Aans 2014mentioning

confidence: 99%

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

Hundepool

Nijhuis

Mohseny

et al. 2014

JNS

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Object. For decades the gold standard for reconstructing a large peripheral nerve defect has been, and remains, the nerve autograft. Alternatives to the nerve autograft include biological conduits and vessels. Adding stem cells in the lumen of a nerve conduit has been the subject of multiple studies. The purpose of the present meta-analysis was to summarize animal experimental studies on the effect of stem cells as a luminal additive when reconstructing a peripheral nerve defect with a nerve graft.Methods. A literature search of the MEDLINE and Embase databases was performed from inception to April 2012, searching for animal experiments on peripheral nerve reconstruction models in which a nerve conduit was used with and without the support of 3 different types of stem cells. Stem cells were analyzed according to their origin: bone marrow, adipose tissue, and other origins. Included studies had consistent outcome measurements: walking track analysis, muscle mass ratio, and electrophysiology.Results. Forty-four studies were included in the final analysis. Forest plots of the 3 outcome measurements (walking track analysis, muscle mass ratio, and electrophysiology) showed positive effects of stem cells on the regeneration of peripheral nerves at different time points. Almost all comparisons showed significant differences for all 3 stem cells groups compared with a control group in which stem cells were not used.Conclusions. The present report systematically analyzed the different studies that used stem cells as a luminal additive when bridging a large peripheral nerve defect. All 3 different stem cell groups showed a beneficial effect when used in the reconstruction compared with control groups in which stem cells were not used. (http://thejns.org/doi/abs/10.3171/2014.4.JNS131260) Key WordS • peripheral nerve defect • stem cells • regeneration • meta-analysisAbbreviations used in this paper: ADSC = adipose-derived stromal cell; BMSC = bone marrow stromal cell; MM = muscle mass ratio; NCV = nerve conduction velocity SFI = Sciatic Functional Index.

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Section: ©Aans 2014mentioning

confidence: 99%

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

Hundepool

Nijhuis

Mohseny

et al. 2014

JNS

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“…To date, ADSCs have become excellent candidates for research and clinical applications. Many studies have shown that ADSC transplantation efficiently improved almost all symptoms of certain diseases, such as liver fibrosis (Harn et al, 2012), nerve defects (Gu et al, 2012;Liu et al, 2011;Santiago et al, 2009), ischemia (Mazo et al, 2012;Rigol et al, 2010), skeletal muscle injury (Pecanha et al, 2012), passive chronic immune thrombocytopenia (Xiao et al, 2012), and myocardial infarction (Yang et al, 2012) in animals, and systemic sclerosis in humans (Riordan et al, 2009;Scuderi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

et al. 2014

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Abstract-Osteoarthritis is one of the most common diseases, and it affects 12% of the population around the world. Although the disease is chronic, it significantly reduces the patient's quality of life. At present, stem cell therapy is considered to be an efficient approach for treating this condition. Mesenchymal stem cells (MSCs) show the most potential for stem cell therapy of osteoarthritis. In fact, MSCs can differentiate into certain mesodermal tissues such as cartilage and bone. Therefore, in the present study, we applied adipose tissue-derived MSCs to osteoarthritis treatment. This study aimed to evaluate the clinical efficiency of autologous adipose tissue-derived MSC transplantation in patients with confirmed osteoarthritis at grade II and III. Adipose tissue was isolated from the belly, and used for extraction of the stromal vascular fraction (SVF). The SVF was mixed with activated platelet-rich plasma before injection. The clinical efficiencies were evaluated by the pain score (VAS), Lysholm score, and MRI findings. We performed the procedure in 21 cases from 2012 to 2013. All 21 patients showed improved joint function after 8.5 months. The pain score decreased from 7.6±0.5 before injection to 3.5±0.7 at 3 months and 1.5±0.5 at 6 months after injection. The Lysholm score increased from 61±11 before injection to 82±8.1 after injection. Significant improvements were noted in MRI findings, with increased thickness of the cartilage layer. Moreover, there were no side-effects or complications related to microorganism infection, graft rejection, or tumorigenesis. These results provide a new opportunity for osteoarthritis treatment. Level of evidence: IV.

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“…The expression of myelin protein zero, peripheral myelin protein-22 and myelin basic protein also suggest the retention of myelinating capability [98] . Although some reports have found no difference in outcome between ADSC-filled conduits and cell deplete products [49] , the vast majority of studies show an augmented effect [13,28,29,31,99] . Several studies have shown that ADSCs are at least as effective as autologous SCs [21,45,51] .…”

Section: Bone Marrow Derived Stem Cellsmentioning

confidence: 99%

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

Fairbairn

Meppelink

Ng-Glazier

et al. 2015

WJSC

128

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Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell (SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration.

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Adipose-derived stem cells promote peripheral nerve repair

Cited by 87 publications

References 21 publications

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

The effect of stem cells in bridging peripheral nerve defects: a meta-analysis

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

Augmenting peripheral nerve regeneration using stem cells: A review of current opinion

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