Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Wei, Hong; Zeng, Rong; Lu, Ja-Yu; Lai, Wen-FuThomas; Chen, Wei Hong; Liu, Hen Yu; Chang, Ya Ting; Deng, Win Ping

doi:10.18632/oncotarget.3481

Cited by 74 publications

(63 citation statements)

References 49 publications

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“…Indeed, recent studies have shown that ADSCs may play a vital role in cancer progression . Some clinical trials also indicated that ADSCs may provide a suitable microenvironment for BCC growth which increases the risks of recurrence and metastasis .…”

Section: Introductionmentioning

confidence: 99%

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Wang¹,

Liu²,

Jiang

et al. 2017

Stem Cells

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Autologous adipose tissue or adipose tissue with additive adipose-derived mesenchymal stem cells (ADSCs) is used in the breast reconstruction of breast cancer patients who undergo mastectomy. ADSCs play an important role in the angiogenesis and adipogenesis, which make it much better than other materials. However, ADSCs may promote residual tumor cells to proliferate or metastasize, and the mechanism is still not fully understood. In this study, we demonstrated that human ADSCs (hADSCs) could facilitate tumor cells growth after co-injection with MCF7 and ZR-75-30 breast cancer cells (BCCs) by promoting angiogenesis, but hADSCs showed limited effect on the growth of MDA-MB-231 BCCs. Intriguingly, compared with ZR-75-30 tumor cells, MCF7 tumor cells were more potentially promoted by hADSCs in the aspects of angiogenesis and proliferation. Consistent with this, cytokine and angiogenesis array analyses showed that after co-injection with hADSCs, the CXCL1 and CXCL8 concentration were significantly increased in MCF7 tumor, but only moderately increased in ZR-75-30 tumor and did not increase in MDA-MB-231 tumor. Furthermore, we found that CXCL1/8 were mainly derived from hADSCs and could increase the migration and tube formation of human umbilical vein endothelial cells (HUVECs) by signaling via their receptors CXCR1 and CXCR2. A CXCR1/2-specific antagonist (SCH527123) attenuated the angiogenesis and tumor growth in vivo. Our findings suggest that CXCL1/8 secreted by hADSCs could promote breast cancer angiogenesis and therefore provide better understanding of safety concerns regarding the clinical application of hADSCs and suggestion in further novel therapeutic options. Stem Cells 2017;35:2060-2070.

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Section: Introductionmentioning

confidence: 99%

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Wang¹,

Liu²,

Jiang

et al. 2017

Stem Cells

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“…and exosomes and extra-cellular matrix components (MMP-11, collagen IV, etc.). [14][15][16][17] Peritumoral edema caused by the release of cytokines can also conduce to decrease the peritumoral fat proportion. Loss of the peritumoral fat content on IDEAL-IQ may reflect these pathological changes in the microenvironment of the breast.…”

Section: Discussionmentioning

confidence: 99%

Peritumoral Fat Content Correlates with Histological Prognostic Factors in Breast Carcinoma: A Study Using Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL)

et al. 2021

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Purpose: To correlate peritumoral fat content using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) with histologic prognostic factors in breast carcinoma. Materials and Methods:This study consisted of 100 patients who were diagnosed with invasive carcinoma of breast and underwent breast MRI including IDEAL before surgery. The scan time of IDEAL fat fraction (FF) map imaging was 33 s. Four regions of interests (ROIs), which are a distance of 5 mm from the tumor edge, and one ROI in the mammary fat of the healthy side were set on the FF map. Then average peritumoral FF values (FFt), average FF values in the healthy side (FFh), and peritumoral fat ratio (pTFR: defined as FFt/FFh) were calculated. Histologically, the presence of lymph node metastasis and the MIB-1 index were evaluated.Results: FFt and pTFR for breast carcinoma with lymph node metastasis (79.27 ± 10.36 and 0.897 ± 0.078) were significantly lower than those without (86.23 ± 4.53 and 0.945 ± 0.032) (P < 0.001 and P = 0.005). Spearman rank correlation suggested that the FFt correlated with the MIB-1 index (r = −340, P = 0.001). Conclusion:Quantification of peritumoral fat using IDEAL-iron quantification is associated with the histologic prognostic factors, and may be a practical tool for therapeutic strategy of breast carcinoma.

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“…The paracrine signaling effects of ASCs on colorectal cancer (CRC) have also been well described in the literature . Wei et al demonstrated that ASCs release the cytokine IL‐6 to act on CRC cells through the JAK2/STAT3 pathway to increase sphere generation and cell growth and upregulate self‐renewal gene expression .…”

Section: Ascs In Cancermentioning

confidence: 99%

“…Wei et al demonstrated that ASCs release the cytokine IL‐6 to act on CRC cells through the JAK2/STAT3 pathway to increase sphere generation and cell growth and upregulate self‐renewal gene expression . Furthermore, cancer cells promoted increased secretion of IL‐6 from ASCs . Li et al demonstrated that senescent ASCs have a more significant impact on CRC cell proliferation than nonsenescent ASCs .…”

Section: Ascs In Cancermentioning

confidence: 99%

Adipose Stem Cells and Cancer: Concise Review

et al. 2019

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It is well established that the tumor microenvironment plays an important role in cancer development and progression. The tumor microenvironment is composed of neoplastic cells, endothelial cells, pericytes, adipocytes, fibroblasts and other connective tissue cells, extracellular matrix components, multiple stem and progenitor cells, and a diverse array of innate and adaptive immune cells [Nat Rev Cancer 2007;7:139–147]. Understanding the mechanisms behind cell–cell communication in the tumor microenvironment is critical to understanding the drivers of tumorigenesis and metastasis. In this review, we discuss the interactions between adipose stem cells, a critical component of the tumor microenvironment, and various forms of cancer. Stem Cells 2019;37:1261–1266

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Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Cited by 74 publications

References 49 publications

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis

Peritumoral Fat Content Correlates with Histological Prognostic Factors in Breast Carcinoma: A Study Using Iterative Decomposition of Water and Fat with Echo Asymmetry and Least-Squares Estimation (IDEAL)

Adipose Stem Cells and Cancer: Concise Review

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