Adipose-derived stromal cell in regenerative medicine: A review

Abstract

The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells (ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years. As medical options, both the stromal vascular and ADSC suggests good opportunity as marvelous cell-based therapeutics. The some biological features are the main factors that impact the regenerative activity of ADSCs, including the modulation of the cellular immune system properties and secretion of bioactive proteins such as cytokines, chemokines and growth factors, as well as their intrinsic anti-ulcer and anti-inflammatory potential. A variety of diseases have been treated by ADSCs, and it is not surprising that there has been great interest in the possibility that ADSCs might be used as therapeutic strategy to improve a wider range of diseases. This is especially important when it is remembered that routine therapeutic methods are not completely effective in treat of diseases. Here, it was discuss about applications of ADSC to colitis, liver failure, diabetes mellitus, multiple sclerosis, orthopaedic disorders, hair loss, fertility problems, and salivary gland damage.

Potential of Allogeneic Adipose-Derived Stem Cell–Hydrogel Complex for Treating Diabetic Foot Ulcers

“…Recently, adipose-derived stem cells (ASCs) have been demonstrated to be one of the main sources of MSCs (7)(8)(9)(10). Kato et al (11) have shown that allogeneic transplantation of an ASC combined with artificial skin can accelerate wound healing in Zucker diabetic fatty rats in vivo.…”

Differential DNA Methylation Encodes Proliferation and Senescence Programs in Human Adipose-Derived Mesenchymal Stem Cells

“…Adipose-derived mesenchymal stem cells (ASCs) represent a population of self-renewing and multipotent cells that reside in the vascular stroma of adipose tissue; under specific conditions, they are capable of differentiating into cellular phenotypes that resemble adipocytes, myocytes, chondrocytes, and osteocytes (Patrikoski et al, 2019). This indigenous cell population is known to play a central role in embryologic development, tissue growth, tissue repair, and regeneration due to its pluripotency and immunomodulatory capacity (Scuderi et al, 2013;Dai et al, 2016;Tabatabaei Qomi and Sheykhhasan, 2017). However, its role in end-organ homeostasis and repair following organ damage remains largely undefined.…”

Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects

“…It has been proven that stem cell therapy can contribute to diabetic wounds and other diseases [4][5][6]. Compared with other types of stem cells, adipose-derived stem cells (ADSCs) have specific advantages and fewer limitations; they are abundant and easily harvested, can be delivered via a minimally invasive procedure, are associated with fewer ethical issues and have less risk of inducing tumorigenicity and the host immune response [7,8].…”