Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

Ren, Lin; Song, Zijun; Cai, Qingwei; Chen, Rui-xin; Zou, Yang; Fu, Qiang; Ma, Yuanyuan

doi:10.1016/j.bbrc.2018.11.109

Cited by 56 publications

(50 citation statements)

References 22 publications

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“…The exosomes produced by MSCs can prevent osteocytes from undergoing apoptosis in a hypoxia/serum deprivation model and glucocorticoid-induced osteonecrosis model. 81,82 The exosomes excreted by iPS-derived MSCs can promote the regeneration of bone defects via enhanced angiogenesis and osteogenesis in an ovariectomized rat model. 83 Exosomal transfer RNA-derived fragments from the plasma of osteoporosis patients, including tRF-25, tRF-38, and tRF-18, were significantly increased compared with those from healthy controls, suggesting that these tRFs may be new diagnostic biomarkers for osteoporosis.…”

Section: Exosomementioning

confidence: 99%

“…134 The effects of exosomes on the signaling pathway of subchondral bone cells, including TGF-β signaling, and their potential roles in OA progression deserve further attention. Cells, including osteoblasts, osteoclasts, osteocytes and bone marrow MSCs, can secrete exosomes to regulate the bone microenvironment and mediate cell-cell communication, [76][77][78][79][80][81][82] but their roles and underlying mechanisms in the remodeling of subchondral bone during the OA process are not well known. Recently, Liu et al harvested subchondral bones from OA patients with different severities of joint wear and obtained osteoblasts from them.…”

Section: Exosomes In Oamentioning

confidence: 99%

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Exosomes: roles and therapeutic potential in osteoarthritis

Ni¹,

et al. 2020

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Exosomes participate in many physiological and pathological processes by regulating cell-cell communication, which are involved in numerous diseases, including osteoarthritis (OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling. This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.

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Section: Exosomementioning

confidence: 99%

Section: Exosomes In Oamentioning

confidence: 99%

Exosomes: roles and therapeutic potential in osteoarthritis

Ni¹,

et al. 2020

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“…Studies have found that osteocytes in bone tissues equip with many functions of coordinating the bone remodeling of osteoclasts and osteoblasts, which maintain the bone homeostasis (Borciani et al, 2020). An in vitro study confirmed that ASC-exos could antagonize osteocyte apoptosis triggered by ischemia and hypoxia, and decrease osteocyte-mediated osteoclastogenesis, which was attributed to the decrease in receptor activator of nuclear factor kappa b ligand (RANKL) expression (Ren et al, 2019). RANKL interacts with its receptor RANK, which is highly expressed by osteoclasts or their precursors and is essential for osteoclast activation (Figure 2A).…”

Section: Asc-exos In Bone Tissue Damagementioning

confidence: 84%

Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery

Xiong

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Adipose-derived stem cells (ASCs) are an important stem cell type separated from adipose tissue, with the properties of multilineage differentiation, easy availability, high proliferation potential, and self-renewal. Exosomes are novel frontiers of intercellular communication regulating the biological behaviors of cells, such as angiogenesis, immune modulation, proliferation, and migration. ASC-derived exosomes (ASC-exos) are important components released by ASCs paracrine, possessing multiple biological activities. Tissue regeneration requires coordinated "vital networks" of multiple growth factors, proteases, progenitors, and immune cells producing inflammatory cytokines. Recently, as cell-to-cell messengers, ASC-exos have received much attention for the fact that they are important paracrine mediators contributing to their suitability for tissue regeneration. ASC-exos, with distinct properties by encapsulating various types of bioactive cargoes, are endowed with great application potential in tissue regeneration, mechanically via the migration and proliferation of repair cells, facilitation of the neovascularization, and other specific functions in different tissues. Here, this article elucidated the research progress of ASC-exos about tissue regeneration in plastic and cosmetic surgery, including skin anti-aging therapy, dermatitis improvement, wound healing, scar removal, flap transplantation, bone tissue repair and regeneration, obesity prevention, fat grafting, breast cancer, and breast reconstruction. Deciphering the biological properties of ASC-exos will provide further insights for exploring novel therapeutic strategies of tissue regeneration in plastic and cosmetic surgery.

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“…AD-MSC EVs reduced hypoxia/serum deprivation-induced apoptosis of osteocyte-like cells through upregulation of Bcl-2/Bax and downregulation of reactive oxygen species (ROS), cytochrome c and activation of caspase-9 and caspase-3. In addition, these EVs reduced osteoclastogenesis suggesting the potential of AD-MSC EVs to improve age-related bone loss [86].…”

Section: Bone Repair and Bone Diseasesmentioning

confidence: 94%

Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases

Alcaraz

Compañ

Guillén

2019

Cells

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Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC effects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair. In this review, we summarize the current understanding of MSC EVs actions in preclinical studies of (1) immune regulation and rheumatoid arthritis, (2) bone repair and bone diseases, (3) cartilage repair and osteoarthritis, (4) intervertebral disk degeneration and (5) skeletal muscle and tendon repair. We also discuss the mechanisms underlying these actions and the perspectives of MSC EVs-based strategies for future treatments of musculoskeletal disorders.

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Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

Cited by 56 publications

References 22 publications

Exosomes: roles and therapeutic potential in osteoarthritis

Exosomes: roles and therapeutic potential in osteoarthritis

Exosomes From Adipose-Derived Stem Cells: The Emerging Roles and Applications in Tissue Regeneration of Plastic and Cosmetic Surgery

Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases

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