Adipose stem cells and donor demographics: Impact of anatomic location, donor sex, race, BMI, and health

Cottrill, Adam; Samadi, Yasamin; Marra, Kacey G.

doi:10.1016/b978-0-12-819376-1.00014-7

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Similarly, variances with respect to patient demographics such as race, ethnicity, and age have been recognized as key players in the development of preclinical breast cancer models for drug efficacy [ 8 , 101 , 102 , 103 ]. To compound the demographic-related challenges, the functional role of adipocytes and adipose tissue must also be taken into careful consideration when integrating the adipose stromal environment into preclinical models [ 22 ]. With respect to experimental design, we must assume that (a) adult stem cell function is dependent on patient or donor physiology and the anatomical harvest location [ 15 ], and (b) the heterogeneity of the resident cell populations in adipose tissue varies from patient to patient and donor to donor [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…between varying ethnic and racial backgrounds [22]. These differences could speak to potential variance in ASC stemness, but further comparative studies must be conducted that include ASCs from donors with differing ethnic backgrounds.…”

Section: Diversity In Breast Cancermentioning

confidence: 99%

“…Furthermore, excessive adipose tissue does not necessarily translate to metabolic dysfunction, as up to thirty percent of obese individuals retain normal indicators of metabolic health [ 21 ]. There is also diversity within the adipose tissue, as evidenced by the observation that total body fat, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and body mass index (BMI) are significantly different between varying ethnic and racial backgrounds [ 22 ]. These differences could speak to potential variance in ASC stemness, but further comparative studies must be conducted that include ASCs from donors with differing ethnic backgrounds.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Hamel,

Frazier,

Williams

et al. 2024

IJMS

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Female breast cancer accounts for 15.2% of all new cancer cases in the United States, with a continuing increase in incidence despite efforts to discover new targeted therapies. With an approximate failure rate of 85% for therapies in the early phases of clinical trials, there is a need for more translatable, new preclinical in vitro models that include cellular heterogeneity, extracellular matrix, and human-derived biomaterials. Specifically, adipose tissue and its resident cell populations have been identified as necessary attributes for current preclinical models. Adipose-derived stromal/stem cells (ASCs) and mature adipocytes are a normal part of the breast tissue composition and not only contribute to normal breast physiology but also play a significant role in breast cancer pathophysiology. Given the recognized pro-tumorigenic role of adipocytes in tumor progression, there remains a need to enhance the complexity of current models and account for the contribution of the components that exist within the adipose stromal environment to breast tumorigenesis. This review article captures the current landscape of preclinical breast cancer models with a focus on breast cancer microphysiological system (MPS) models and their counterpart patient-derived xenograft (PDX) models to capture patient diversity as they relate to adipose tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Diversity In Breast Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Hamel,

Frazier,

Williams

et al. 2024

IJMS

View full text Add to dashboard Cite

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Quality Control in Human Adipose-Derived Stromal/Stem Cells and Tissue Engineering Fat Models for Aging Studies

Hamel,

Robinson,

Rogers

et al. 2024

Methods in Molecular Biology

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State of the field: cellular and exosomal therapeutic approaches in vascular regeneration

Tracy

Steilberg

Rowe

et al. 2022

American Journal of Physiology-Heart and Circulatory Physiology

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Pathologies of the vasculature and microvasculature are often complex in nature, leading to loss of physiological homeostatic regulation of patency and adequate perfusion to match tissue metabolic demands. Contributing pathological factors include endothelial dysfunction, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, loss of angiogenic potential and vascular density, and greater senescence and apoptosis. In many clinical settings, current pharmacologic strategies lack holistic mechanisms whilst addressing symptoms of pathology rather than their root cause. To address this, efforts have been heavily focused on cellular therapies that can tackle the multifaceted etiology of vascular and microvascular dysfunction. In this review, we discuss 1) the state of the field in terms of common therapeutic cell population isolation techniques, their unique characteristics and their advantages and disadvantages, 2) common molecular mechanisms of cell therapies to restore vascularization and/or vascular function, 3) arguments for and against allogenic vs. autologous applications of cell therapies, 4) emerging strategies to optimize and enhance cell therapies through priming and preconditioning, and finally, 5) emerging dosing and administrative strategies to bolster therapeutic effect. Significant clinical and animal studies of emerging cellular therapies to restore vascular function or pathologic tissue health by way of improved vascularization are highlighted throughout these sections.

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Adipose stem cells and donor demographics: Impact of anatomic location, donor sex, race, BMI, and health

Cited by 4 publications

References 37 publications

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models

Quality Control in Human Adipose-Derived Stromal/Stem Cells and Tissue Engineering Fat Models for Aging Studies

State of the field: cellular and exosomal therapeutic approaches in vascular regeneration

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