Adipose tissue: a regulator of inflammation

Juge-Aubry, Cristiana E.; Henrichot, Elvire; Meier, Christoph A.

doi:10.1016/j.beem.2005.07.009

Cited by 298 publications

(236 citation statements)

References 116 publications

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“…Although several adipokines involved in energy homeostasis were discovered in recent years, the so far most studied ones are leptin, adiponectin, resistin, angiopoietin-like protein 4, and preadipocyte factor 1, on which this section will concentrate. In addition, information on other adipokines is given in Table 1 and Figure 4, or can be found in several review articles [26,[34][35][36][37][38].…”

Section: Adipokines Directly Involved In Energy Homeostasismentioning

confidence: 99%

“…Some of these adipokines are synthesized by adipocytes, whereas others are produced by the haematopoietic cell fraction of the WAT (in macrophages, T-cells, B-cells, natural killer cells), or cells from the SVF [36,77,78]. A large number of studies suggest that adipose tissue inflammation is associated with metabolic diseases, such as insulin resistance and other obesity-related complications, and lipodystrophy [79][80][81][82][83][84] (reviewed in [85]).…”

Section: Adipokines Chemokines and Vascular Proteins Involved In Prmentioning

confidence: 99%

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Fat poetry: a kingdom for PPARγ

2007

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Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. In addition to managing the most important energy reserve of the body, it secretes a multitude of soluble proteins called adipokines, which have beneficial or, alternatively, deleterious effects on the homeostasis of the whole body. The expression of these adipokines is an integrated response to various signals received from many organs, which depends heavily on the integrity and physiological status of the adipose tissue. One of the main regulators of gene expression in fat is the transcription factor peroxisome proliferatoractivated receptor g (PPARg), which is a fatty acid-and eicosanoid-dependent nuclear receptor that plays key roles in the development and maintenance of the adipose tissue. Furthermore, synthetic PPARg agonists are therapeutic agents used in the treatment of type 2 diabetes.This review discusses recent knowledge on the link between fat physiology and metabolic diseases, and the roles of PPARg in this interplay via the regulation of lipid and glucose metabolism. Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPARg modulators.

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Section: Adipokines Directly Involved In Energy Homeostasismentioning

confidence: 99%

Section: Adipokines Chemokines and Vascular Proteins Involved In Prmentioning

confidence: 99%

Fat poetry: a kingdom for PPARγ

2007

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“…Adipokines include several cytokines, chemokines, and hormone-like factors that participate in the regulation of physiological and pathological processes such as metabolism, immunity, and inflammation [1,2]. Resistin, known as adipocyte-secreted factor (ADSF) or found in inflammatory zone 3 (FIZZ3), was discovered in 2001 and was proposed as a potential link between obesity and diabetes [3].…”

Section: Introductionmentioning

confidence: 99%

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Filková

Haluzı́k

Šenolt

2009

Clinical Immunology

375

297

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“…Indeed, IL 1Ra is an antiinflammatory cytokine that is markedly increased in human obesity; data from rodents strongly suggest that this peptide has important central and peripheral metabolic functions ( Juge-Aubry et al 2005). This review will address present knowledge about the involvement of the most relevant adipokines in the physiology of skeleton with a particular focus on chondrocyte function (Fig.…”

Section: Introductionmentioning

confidence: 99%

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

Gómez

Lago²,

Gómez-Reino³

et al. 2009

Journal of Molecular Endocrinology

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The discovery of leptin in 1994 marked the beginning of a new understanding about white adipose tissue (WAT) and modified a static vision of this tissue which was viewed up to the end of the 20th century as an inert tissue, devoted to body protection from heat loss and to passively storing energy. The identification of the product of the gene obese accentuated the role of adipose tissue in the physiopathology of obesity-linked diseases, and led to the discovery of various adipokines, many of a pro-inflammatory nature. It has become progressively manifest that WAT-derived adipokines can now be considered as the fulcrum between obesity-related environmental causes, such as nutrition and lifestyle, and the biochemical shifts that lead to metabolic syndrome, inflammatory and/or autoimmune conditions, and rheumatic diseases. Herein, we review recent adipokine research, with particular emphasis to the role of leptin, adiponectin, resistin, and visfatin in chondrocyte function and skeleton, as well as in inflammatory and degenerative cartilage joint diseases.

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Adipose tissue: a regulator of inflammation

Cited by 298 publications

References 116 publications

Fat poetry: a kingdom for PPARγ

Fat poetry: a kingdom for PPARγ

The role of resistin as a regulator of inflammation: Implications for various human pathologies

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

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