Adipose Tissue and Serum CCDC80 in Obesity and Its Association with Related Metabolic Disease

Osorio-Conles, Óscar; Guitart, María; Moreno-Navarrete, José María; Escoté, Xavier; Durán, Xavier; Fernández‐Real, José Manuel; Gómèz-Foix, Anna M.; Fernández‐Veledo, Sonia; Vendrell, Joan

doi:10.2119/molmed.2017.00067

Cited by 22 publications

(25 citation statements)

References 38 publications

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“…These results are concordant with previous findings of negative correlation between serum CCDC80 and FBG in adults [19]. Moreover, recent data has indicated that serum level of CCDC80 is linked with glucose clearance and insulin secretion [18]. From the above, we reasoned that circulating CCDC80 may be an effecient biomarker for GDM.…”

Section: Discussionsupporting

confidence: 92%

“…These findings are in line with prior views of negative correlation between CCDC80 and Table 3 Conditional multi-logistic regression analysis Model 1: Unadjusted; Model 2: Adjusted for ALT, AST and creatinine; Model 3: Adjusted for IL-6 and CRP; Model 4 Adjusted for triglyceride, cholesterol, HDL-C, LDL-C, apoA1 and apoB. *P < 0.05 a The OR (95% CI) of CCDC80 z-scores using a conditional logistic regression b The OR (95% CI) referenced to the lowest level using a conditional logistic regression glucose levels just at 30 min post-OGTT [18]. Besides, our analysis found that CCDC80 was positively correlated with AST and MAO, indicating a positive correlation with liver function.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, CCDC80 might be a novel regulator of energy and glucose metabolism in mice. Meanwhile, a small population-based epidemiological survey has demonstrated that CCDC80 may be a component of the obesity-linked secretome in visceral adipose tissue and whose blood levels are connected to glucose intolerance and low-grade inflammation related chronic complications [18]. And, Li et al found that serum CCDC80 was negatively correlated with fasting blood glucose (FBG) in overweight and obesity subjects [19].…”

Section: Introductionmentioning

confidence: 99%

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A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study

Liu

Wang

et al. 2020

BMC Pregnancy Childbirth

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Background: Gestational diabetes mellitus (GDM) is a growing global epidemic. Our study aims to confirm the association between circulatory coiled-coil domain-containing 80 (CCDC80) in pregnant women with GDM, to investigate the discriminatory power of CCDC80 on GDM, and to explore the relationships between this molecular level and clinical cardiometabolic parameters. Methods: A 1:2 matched case-control study with 61 GDM patients and 122 controls was conducted using a propensity score matching protocol. All participants were screened from a multicenter prospective pre-birth cohort: Born in Shenyang Cohort Study (BISCS). During 24 and 28 weeks of gestation, follow-up individuals underwent an oral glucose tolerance test (OGTT) and blood sampling for cardiometabolic characterization. Results: Following propensity score matching adjustment for clinical variables, including maternal age, gestational age, body mass index, SBP and DBP, plasma CCDC80 levels were significantly decreased in patients with GDM when compared with controls (0.25 ± 0.10 vs. 0.31 ± 0.12 ng/ml, P = 0.003). Conditional multi-logistic regression analyses after adjustments for potential confounding factors revealed that CCDC80 was a strong and independent protective factor for GDM (ORs < 1). In addition, the results of the ROC analysis indicated the CCDC80 exhibited the capability to identify pregnant women with GDM (AUC = 0.633). Finally, multivariate regression analyses showed that CCDC80 levels were positively associated with AST, monoamine oxidase, complement C1q, LDL-C, apolipoprotein A1and B, and negatively associated with blood glucose levels at 1 h post-OGTT. Conclusions: Biomarker CCDC80 could be of great value for the development of prediction, diagnosis and therapeutic strategies against GDM in pregnant women.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study

Liu

Wang

et al. 2020

BMC Pregnancy Childbirth

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“…Finally, we detected that plasma CCDC80 level was positively associated with the dyslipidemia and atherosclerosis marker LDL-C, apoA1 and apoB. These findings are consistent with earlier surveys, which has indicated that blood CCDC80 is positively correlated with atherosclerosis and fasting triglyceride levels [18]. We 10 speculated that circulating CCDC80 might be involved with obesity-related processes.…”

Section: Discussionsupporting

confidence: 91%

“…Of note, although a higher expression of CCDC80 in visceral adipose tissue of obese subjects, the circulating CCDC80 was not connected to maternal BMI in the current study, either before or after PSM (r = -0.036, P = 0.528 and r = 0.044, P = 0.556, respectively). Previous study has yielded similar results [18].…”

Section: Discussionsupporting

confidence: 77%

A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study

Liu¹,

Hu²,

Wang

et al. 2020

Preprint

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Background: Gestational diabetes mellitus (GDM) is a growing global epidemic. Our study aims to confirm the association between circulatory coiled-coil domain-containing 80 (CCDC80) in pregnant women with GDM, to investigate the discriminatory power of CCDC80 on GDM, and to explore the relationships between this molecular level and clinical cardiometabolic parameters. Methods: A 1:2 matched case-control study with 61 GDM patients and 122 controls was conducted using a propensity score matching protocol. All participants were screened from a multicenter prospective pre-birth cohort: Born in Shenyang Cohort Study (BISCS). During 24 and 28 weeks of gestation, follow-up individuals underwent an oral glucose tolerance test (OGTT) and blood sampling for cardiometabolic characterization. Results: Following propensity score matching adjustment for clinical variables, including maternal age, gestational age, body mass index, SBP and DBP, plasma CCDC80 levels were significantly decreased in patients with GDM when compared with controls (0.25±0.10 vs. 0.31±0.12 ng/ml, P =0.003). Conditional multi-logistic regression analyses after adjustments for potential confounding factors revealed that CCDC80 was a strong and independent protective factor for GDM (ORs <1). In addition, the results of the ROC analysis indicated the CCDC80 exhibited the capability to identify pregnant women with GDM (AUC=0.633). Finally, multivariate regression analyses showed that CCDC80 levels were positively associated with AST, monoamine oxidase, complement C1q, LDL-C, apolipoprotein A1and B, and negatively associated with blood glucose levels at 1 h post- OGTT. Conclusions: Biomarker CCDC80 could be of great value for the development of prediction, diagnosis and therapeutic strategies against GDM in pregnant women.

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Does adipose tissue inflammation drive the development of non-alcoholic fatty liver disease in obesity?

Cordeiro

Costa

Andrade

et al. 2020

Clinics and Research in Hepatology and Gastroenterology

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Adipose Tissue and Serum CCDC80 in Obesity and Its Association with Related Metabolic Disease

Cited by 22 publications

References 38 publications

A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study

A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study

A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study

Does adipose tissue inflammation drive the development of non-alcoholic fatty liver disease in obesity?

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