Adipose Tissue as Pain Generator in the Lower Back and Lower Extremity: Application in Musculoskeletal Medicine

Lee, Se Won; Dien, Craig Van; Won, Sun Jae

doi:10.36518/2689-0216.1102

Cited by 3 publications

(3 citation statements)

References 90 publications

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“…11 Another potential mechanism involves nerve compression in the septa, surrounding the growing fatty lobules within adipose tissue. 53 However, while the volume of lipedema and the pain intensity influenced daily functioning in our study, surprisingly, they did not affect the severity of depressive and anxiety symptoms. Similarly, the lower limbs' circumference and pain intensity were not associated with the severity of emotional symptoms.…”

Section: Discussioncontrasting

confidence: 66%

Disability and emotional symptoms in women with lipedema: A comparison with overweight/obese women

Chachaj,

Jeziorek,

Dudka

et al. 2024

Adv Clin Exp Med

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Background. Lipedema is characterized by the painful abnormal deposition of adipose tissue in the lower limbs and is often misdiagnosed as obesity. Considering the numerous bothersome physical symptoms of lipedema, women with lipedema may have greater disability and emotional problems than women with lifestyle-induced obesity.Objectives. Our study aims to assess disability, anxiety and depression symptoms in women with lipedema compared to women with overweight/obesity. Materials and methods.Women with lipedema (n = 45, with a mean age of 41 years) and women who are overweight/obese (n = 43, with a mean age of 44.95 years) were asked to complete the following questionnaires: The World Health Organization Disability Assessment Schedule (WHO-

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Section: Discussioncontrasting

confidence: 66%

Disability and emotional symptoms in women with lipedema: A comparison with overweight/obese women

Chachaj,

Jeziorek,

Dudka

et al. 2024

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Masruroh and Setyadhani showed a direct correlation between obesity level and the incidence of knee joint pain in the elderly in a cross-sectional approach on 50 individuals [ 24 ]. A proposed mechanism associated with obesity and musculoskeletal disorders arises from the production of pro-inflammatory cytokines from high excess adipose tissue in obese individuals [ 25 ]. Leptin is a pro-inflammatory adipokine that is highly elevated in obese individuals in which leads to deforming cartilage and be involved in the pathogenesis of arthralgia [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Obesity phenotypes related to musculoskeletal disorders; a cross-sectional study from RaNCD cohort

et al. 2022

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Background This study was evaluated the association between obesity phenotypes and risk of lower torso musculoskeletal disorders including low back pain (LBP), low back stiffness (LBS), arthralgia, and joint stiffness in Ravansar non-communicable diseases (RaNCD) cohort study. Methods In this cross-sectional study, 6940 adults were examined for the presence of lower torso musculoskeletal disorders by a physician. Obesity phenotypes including metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) were defined based on the International Diabetes Federation, as well as, body mass index > 30 kg/m2. Metabolically unhealthy non-obesity (MUNO) phenotype was considered as unhealthy metabolic without obesity. Results The prevalence of LBP, LBS, arthralgia, and joint stiffness in MHO, MUO, and MUNO were significantly higher than in healthy participants compared to obesity phenotypes. Logistic regression showed that MHO phenotype was significantly increased with risk of LBP (OR: 1.19, CI 95%: 1.01–1.41), LBS (OR: 1.44, CI 95%: 1.12–1.86), arthralgia (OR: 1.54, CI 95%: 1.33–1.78), and joint stiffness (OR: 1.84, CI 95%: 1.35–2.52). Moreover, MUO phenotype was positively associated with risk of LBS (OR: 1.46, CI 95%: 1.09–1.94) and arthralgia (OR: 1.66, CI 95%: 1.41–1.96). In addition, MUNO phenotype was associated with a higher risk of arthralgia (OR: 1.21, CI 95%: 1.06–1.37). Conclusion All three phenotypes, MHO, MUO and MUNO were significantly increased the risk of arthralgia. However, MHO phenotype was significantly associated with a higher risk of all examined lower torso musculoskeletal disorders in the current study.

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“…Perhaps the recent trend toward studying brown fat could shed light on the proper knowledge of this tissue. A final point is that the medical community appears to be shifting from the perception that adipose tissue has only storage and protective functions [ 66 ].…”

Section: Clinical Features According To Researchmentioning

confidence: 99%

Historical Review of Studies on Sacroiliac Fatty Nodules (Recently Termed “Back Mice”) as a Potential Cause of Low Back Pain

2021

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Low back pain is a widespread and poorly understood condition that is frequently diagnosed as non-specific low back pain. We were intrigued by the presence of painful sacroiliac nodules in patients with this condition. We conducted a historical review to elucidate this relationship. This chronicled review summarizes the overlooked literature from different countries, especially from around the 1950s, regarding the diagnosis and management of these painful nodules. Biopsies have confirmed the adipose nature of these nodules and revealed distinct pathological signs, including oedema and fascial fatty herniation. Studies have suggested both intra-nodule local anaesthetic injection and surgery as successful treatments for managing pain on a short-or longterm basis. Recent ultrasound studies have confirmed these findings. The various terms used for these nodules over time are specifically described. We conclude that it may be necessary to reconsider the role of fatty tissue in the aetiology and treatment of low back pain in today's mainstream medicine. This could lead to advances in understanding unexplained musculoskeletal pain disorders beyond low back pain. Meanwhile, despite the remaining questions, the treatments identified in these studies can help physicians manage patients' unresolved pain. We recommend that future research use this review as a foundation for further study.

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Adipose Tissue as Pain Generator in the Lower Back and Lower Extremity: Application in Musculoskeletal Medicine

Cited by 3 publications

References 90 publications

Disability and emotional symptoms in women with lipedema: A comparison with overweight/obese women

Disability and emotional symptoms in women with lipedema: A comparison with overweight/obese women

Obesity phenotypes related to musculoskeletal disorders; a cross-sectional study from RaNCD cohort

Historical Review of Studies on Sacroiliac Fatty Nodules (Recently Termed “Back Mice”) as a Potential Cause of Low Back Pain

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